Inositol 1,4,5-Trisphosphate Receptors in Hypertension [PDF]
Frontiers in Physiology, 2018 Chronic hypertension remains a major cause of global mortality and morbidity. It is a complex disease that is the clinical manifestation of multiple genetic, environmental, nutritional, hormonal, and aging-related disorders.
Ali H. Eid +10 more
doaj +5 more sources
Regulatory effects of inositol 1,4,5-trisphosphate receptor genes knockdown on intracellular Ca²⁺ concentration and ion channel–related gene expression in duck uterine epithelial cells [PDF]
Poultry ScienceThis study employed primary uterine epithelial cells from Sansui ducks (Anas platyrhynchos) at the peak of lay as an in vitro model. Using shRNA-mediated interference, we generated single knockdowns of inositol 1,4,5-trisphosphate receptor type 1 (IP3R1),
Yong Zhao +5 more
doaj +2 more sources
Origin, evolution, and diversification of inositol 1,4,5-trisphosphate 3-kinases in plants and animals [PDF]
BMC GenomicsBackground In Eukaryotes, inositol polyphosphates (InsPs) represent a large family of secondary messengers and play crucial roes in various cellular processes.
Tao Xiong +4 more
doaj +2 more sources
Inositol Adenophostin: Convergent Synthesis of a Potent Agonist of d-myo-Inositol 1,4,5-Trisphosphate Receptors [PDF]
ACS Omega, 2020 D-myo-Inositol 1,4,5-trisphosphate receptors (IP3Rs) are Ca2+ channels activated by the intracellular messenger inositol 1,4,5-trisphosphate (IP3, 1). The glyconucleotide adenophostin A (AdA, 2) is a potent agonist of IP3Rs. A recent synthesis of D-chiro-
Xiangdong Su +6 more
doaj +3 more sources
Inositol 1,4,5-trisphosphate receptors in the heart
Biological Research, 2004 Inositol 1,4,5-trisphosphate (InsP3) is an established calcium-mobilizing messenger, which is well-known to activate Ca2+ signaling in many cell types. Contractile cardiomyocytes express hormone receptors that are coupled to the production of InsP3. Such
LAUREN MACKENZIE +4 more
doaj +5 more sources
Inositol 1,4,5-trisphosphate receptors are essential for fetal-maternal connection and embryo viability. [PDF]
PLoS Genetics, 2020 Inositol 1,4,5-trisphosphate receptors (IP3Rs) are a family of intracellular Ca2+ release channels located on the ER membrane, which in mammals consist of 3 different subtypes (IP3R1, IP3R2, and IP3R3) encoded by 3 genes, Itpr1, Itpr2, and Itpr3 ...
Feili Yang +12 more
doaj +2 more sources
Stepwise enzymatic dephosphorylation of inositol 1,4,5-trisphosphate to inositol in liver
Nature, 1984 Many receptors for hormones, neurotransmitters and other signals cause hydrolysis of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and effect a rise in cytosolic Ca2+ concentration. The inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) liberated during PtdIns(4,5)P2 breakdown seems to serve as a second messenger that activates the release of Ca2 ...
D J, Storey +3 more
openaire +3 more sources
Myo-D-inositol Trisphosphate Signalling in Oomycetes
Microorganisms, 2022 Oomycetes are pathogens of plants and animals, which cause billions of dollars of global losses to the agriculture, aquaculture and forestry sectors each year.
Indu Muraleedharan Nair +3 more
doaj +1 more source
IP3 3-kinase opposes NGF driven neurite outgrowth. [PDF]
PLoS ONE, 2012 The inositol (1,4,5) trisphosphate 3-kinases comprise a family of enzymes (A, B, and C) that phosphorylate the calcium mobilising molecule inositol (1,4,5) trisphosphate (IP(3)) to generate inositol (1,3,4,5) tetrakisphosphate. This molecule can function
Richard Eva +4 more
doaj +1 more source
Waves of calcium depletion in the sarcoplasmic reticulum of vascular smooth muscle cells: an inside view of spatiotemporal Ca2+ regulation. [PDF]
PLoS ONE, 2013 Agonist-stimulated smooth muscle Ca2+ waves regulate blood vessel tone and vasomotion. Previous studies employing cytoplasmic Ca2+ indicators revealed that these Ca2+ waves were stimulated by a combination of inositol 1,4,5-trisphosphate- and Ca2 ...
Mitra Esfandiarei +5 more
doaj +1 more source