Results 31 to 40 of about 58,268 (235)

Quantal responses to inositol 1,4,5-trisphosphate are not a consequence of Ca2+ regulation of inositol 1,4,5-trisphosphate receptors [PDF]

Biochemical Journal, 1995
Submaximal concentrations of inositol 1,4,5-trisphosphate (InsP3) rapidly release only a fraction of the InsP3-sensitive intracellular Ca2+ stores, despite the ability of further increases in InsP3 concentration to evoke further Ca2+ release. The mechanisms underlying such quantal Ca2+ mobilization are not understood, but have been proposed to involve ...
S, Patel, C W, Taylor
openaire   +2 more sources

Identification and characterization of insulin-like growth factor receptors on adult rat cardiac myocytes: linkage to inositol 1,4,5-trisphosphate formation. [PDF]

, 1992
Cultured cardiac myocytes from adult Sprague-Dawley rats express both insulin-like growth factor-I (IGF-I) receptors and insulin-like growth factor-II/mannose 6-phosphate (IGF-II/Man6P) receptors and respond to IGF-I with a dose-dependent accumulation of
Berg, Ingeborg, Guse, Andreas H., Kessler, Ulrike, Funk, Barbara, Gercken, Günther, A. H. Guse, Kiess, Wieland   +6 more
core   +2 more sources

Inositol 1,4,5- trisphosphate receptor function in Drosophila insulin producing cells. [PDF]

PLoS ONE, 2009
The Inositol 1,4,5- trisphosphate receptor (InsP(3)R) is an intracellular ligand gated channel that releases calcium from intracellular stores in response to extracellular signals.
Neha Agrawal, Nisha Padmanabhan, Gaiti Hasan   +2 more
doaj   +1 more source

Endoplasmic Reticulum Is a Key Organella in Bradykinin-Triggered ATP Release From Cultured Smooth Muscle Cells

Journal of Pharmacological Sciences, 2007
ATP has broad functions as an autocrine/paracrine molecule. The mode of ATP release and its intracellular source, however, are little understood. Here we show that bradykinin via B2-receptor stimulation induces the extracellular release of ATP via the ...
Yumei Zhao, Keisuke Migita, Chiemi Sato, Sadaharu Usune, Takahiro Iwamoto, Takeshi Katsuragi   +5 more
doaj   +1 more source

The size of inositol 1,4,5-trisphosphate-sensitive Ca2+ stores depends on inositol 1,4,5-trisphosphate concentration [PDF]

Biochemical Journal, 1990
An explanation of the complex effects of hormones on intracellular Ca2+ requires that the intracellular actions of Ins(1,4,5)P3 and the relationships between intracellular Ca2+ stores are fully understood. We have examined the kinetics of 45Ca2+ efflux from pre-loaded intracellular stores after stimulation with Ins(1,4,5)P3 or the stable ...
C W, Taylor, B V, Potter
openaire   +2 more sources

Junctate is a key element in calcium entry induced by activation of InsP3 receptors and/or calcium store depletion [PDF]

, 2004
In many cell types agonist-receptor activation leads to a rapid and transient release of Ca(2+) from intracellular stores via activation of inositol 1,4,5 trisphosphate (InsP(3)) receptors (InsP(3)Rs).
Arnoult, Christophe, Cristiano Grasso, Treves, Susan, Ronjat, Michel, Mikoshiba, Katsuhiko, ARNOULT C, GRASSO C, TREVES, Susan Nella, Ducreux, Sylvie, DUCREUX S, Smida-Rezgui, Sophia, Franzini-Armstrong, Clara, MIKOSHIBA K, SCHRUM A, Sylvie Ducreux, Susan Treves, RONJAT M, Grasso, Cristiano, Zhu, Michael X., Zorzato, Francesco, SMIDA REZGUI S, Sophia Smida-Rezgui, MOCCAGATTA L, Zhu, Michael, Francesco Zorzato, Clara Franzini-Armstrong, Christophe Arnoult, Luca Moccagatta, Schrum, Adam, Michel Ronjat, ZHU MX, GIRARD T, Girard, Thierry, Katsuhiko Mikoshiba, Thierry Girard, FRANZINI ARMSTRONG C, Moccagatta, Luca, Michael X. Zhu, Adam Schrum   +38 more
core   +1 more source

IP3 Receptor-Mediated Calcium Signaling and Its Role in Autophagy in Cancer

Frontiers in Oncology, 2017
Calcium ions (Ca2+) play a complex role in orchestrating diverse cellular processes, including cell death and survival. To trigger signaling cascades, intracellular Ca2+ is shuffled between the cytoplasm and the major Ca2+ stores, the endoplasmic ...
Elzbieta Kania, Gemma Roest, Tim Vervliet, Jan B. Parys, Geert Bultynck   +4 more
doaj   +1 more source

Selective determinants of inositol 1,4,5‐trisphosphate and adenophostin A interactions with type 1 inositol 1,4,5‐trisphosphate receptors [PDF]

British Journal of Pharmacology, 2010
BACKGROUND AND PURPOSEAdenophostin A (AdA) is a potent agonist of inositol 1,4,5‐trisphosphate receptors (IP3R). AdA shares with IP3the essential features of all IP3R agonists, namely structures equivalent to the 4,5‐bisphosphate and 6‐hydroxyl of IP3, but the basis of its increased affinity is unclear.
Rossi, A, Sureshan, K, Riley, A, Potter, B, Taylor, C   +4 more
openaire   +3 more sources

The Inositol- 1,4,5=Trisphosphate System Is Involved in Rapid Effects of Aldosterone in Human Mononuclear Leukocytes [PDF]

, 1993
There is increasing evidence for rapid steroid action on electrolyte transport in human mononuclear leukocytes (HML). In HML, aldosterone stimulates the Na+/H+ antiporter within a few minutes. Because a variety of hormones and growth factors activate the
Wehling, Martin, Theisen, Karl, Eisen, Christoph, Aktas, Janet, Christ, Michael, M. Christ   +5 more
core   +1 more source

Role of the inositol 1,4,5-trisphosphate receptor/Ca²⁺-release channel in autophagy

Cell Communication and Signaling, 2012
Autophagy is an important cell-biological process responsible for the disposal of long-lived proteins, protein aggregates, defective organelles and intracellular pathogens.
Parys Jan B, Decuypere Jean-Paul, Bultynck Geert   +2 more
doaj   +1 more source