Results 51 to 60 of about 58,268 (235)

MiR-135a-5p Is Critical for Exercise-Induced Adult Neurogenesis

Stem Cell Reports, 2019
Summary: Physical exercise stimulates adult hippocampal neurogenesis and is considered a relevant strategy for preventing age-related cognitive decline in humans. The underlying mechanisms remains controversial.
Meritxell Pons-Espinal, Caterina Gasperini, Matteo J. Marzi, Clarissa Braccia, Andrea Armirotti, Alexandra Pötzsch, Tara L. Walker, Klaus Fabel, Francesco Nicassio, Gerd Kempermann, Davide De Pietri Tonelli   +10 more
doaj   +1 more source

Inositol 1,4,5‐trisphosphate receptors and neurodegenerative disorders [PDF]

The FEBS Journal, 2018
The inositol 1,4,5‐trisphosphate receptor (IP3R) is an intracellular ion channel that mediates the release of calcium ions from the endoplasmic reticulum. It plays a role in basic biological functions, such as cell division, differentiation, fertilization and cell death, and is involved in developmental processes including learning, memory and behavior.
Polina A, Egorova, Ilya B, Bezprozvanny
openaire   +2 more sources

Porcine Circovirus Type 2 Activates CaMMKβ to Initiate Autophagy in PK-15 Cells by Increasing Cytosolic Calcium

Viruses, 2016
Porcine circovirus type 2 (PCV2) induces autophagy via the 5′ adenosine monophosphate-activated protein kinase (AMPK)/extracellular signal-regulated kinase (ERK)/tuberous sclerosis complex 2 (TSC2)/mammalian target of rapamycin (mTOR) pathway in pig ...
Yuanxing Gu, Baozhu Qi, Yingshan Zhou, Xiaowu Jiang, Xian Zhang, Xiaoliang Li, Weihuan Fang   +6 more
doaj   +1 more source

Lipopolysaccharide induces endoplasmic store Ca2+-dependent inflammatory responses in lung microvessels. [PDF]

PLoS ONE, 2013
The pulmonary microvasculature plays a critical role in endotoxin-induced acute lung injury. However, the relevant signaling remain unclear. Specifically the role of endothelial Ca(2+) in the induction of endotoxin-mediated responses in lung microvessels
Kathirvel Kandasamy, Lavanya Bezavada, Rachel B Escue, Kaushik Parthasarathi   +3 more
doaj   +1 more source

Dephosphorylation of myo-inositol 1,4,5-trisphosphate and myo-inositol 1,3,4-trisphosphate [PDF]

, 1987
We have augmented our previous studies [Storey, Shears, Kirk & Michell (1984) Nature (London) 312, 374-376] on the subcellular location and properties of Ins(1,4,5)P3 (inositol 1,4,5-trisphosphate) phosphatases in rat liver and human erythrocytes. We
Storey, DJ, Shears, SB, Cubitt, AB, Parry, JB, Kirk, CJ, Morris, AJ, Michell, RH   +6 more
core   +1 more source

Mice lacking inositol 1,4,5-trisphosphate receptors exhibit dry eye.

PLoS ONE, 2014
Tear secretion is important as it supplies water to the ocular surface and keeps eyes moist. Both the parasympathetic and sympathetic pathways contribute to tear secretion. Although intracellular Ca2+ elevation in the acinar cells of lacrimal glands is a
Takaaki Inaba, Chihiro Hisatsune, Yasumasa Sasaki, Yoko Ogawa, Etsuko Ebisui, Naoko Ogawa, Minoru Matsui, Tsutomu Takeuchi, Katsuhiko Mikoshiba, Kazuo Tsubota   +9 more
doaj   +1 more source

Ca2+-Dependent Inositol 1,4,5-Trisphosphate and Nitric Oxide Signaling in Cerebellar Neurons

Journal of Pharmacological Sciences, 2006
.: Intracellular Ca2+ signals are important for the regulation of synaptic functions in the central nervous system. In this review, I summarize findings of our recent studies on upstream and downstream Ca2+ signaling mechanisms in cerebellar synapses ...
Masamitsu Iino
doaj   +1 more source

VDAC1 Upregulation Induces Hyperexcitability of Nociceptive Sensory Neurons Via Enhanced Mitochondrial Atp Efflux in Neuropathic Pain

Advanced Science, EarlyView.
The mechanism diagram of VDAC1 mediating neuronal excitability and neuropathic pain. Briefly, VDAC1 is expressed in DRG neurons and is upregulated following CCI‐induced neuropathic pain. This upregulation enhances ATP transport from mitochondria to the cytoplasm in sensory neurons, leading to increased neuronal excitability and pain behavior.
Fengrun Sun, Ning Yu, Liang Yu, Xiaofen Tian, Yujia Ma, Yikuan Xie, Tao Wang, Chao Ma   +7 more
wiley   +1 more source

Single‐Cell Profiling Identifies SLC2A5‐Mediated Fructose Metabolism as a Vulnerability in Primary CNS Lymphoma

Advanced Science, EarlyView.
Glucose deprivation in the primary CNS lymphoma (PCNSL) tumor microenvironment drives SLC2A5 (encoding GLUT5)‐dependent fructose metabolism in tumor cells, while hypoxia induces HIF‐mediated SLC2A5 expression in tumor‐supportive macrophages, revealing SLC2A5‐driven fructose utilization as a shared and targetable metabolic vulnerability across malignant
Qiaoli Wu, Qianru Zhang, Wenqiang Yan, Lu Sun, Yiran Cui, Bolin Liu, Guoqing Han, Feng Zhang, Ke Pu, Mingchao Zhang, Xiaobing Zhang, Qingguo Li, Gang An, Yuxuan Liu   +13 more
wiley   +1 more source

Cell cycle-dependent regulation of structure of endoplasmic reticulum and inositol 1,4,5-trisphosphate-induced Ca2+ release in mouse oocytes and embryos [PDF]

, 2003
The organization of endoplasmic reticulum (ER) was examined in mouse eggs undergoing fertilization and in embryos during the first cell cycle. The ER in meiosis 11 (MII)-arrested mouse eggs is characterized by accumulations (clusters) that are restricted
Carroll, J, Marangos, P, FitzHarris, G
core