Results 191 to 200 of about 58,268 (235)
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Journal of Receptors and Signal Transduction, 1995
Inositol 1,4,5-trisphosphate (IP3)-induced release of Ca2+, its regulation by IP3 and Ca2+, and the metabolism of IP3 was analyzed in saponin-permeabilized human platelets. At 37 degrees C successive sub-maximal aliquots of IP3 induce a biphasic release of part of the IP3-sensitive Ca2+ pool each time.
Eberhard M, Erne P
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Inositol 1,4,5-trisphosphate (IP3)-induced release of Ca2+, its regulation by IP3 and Ca2+, and the metabolism of IP3 was analyzed in saponin-permeabilized human platelets. At 37 degrees C successive sub-maximal aliquots of IP3 induce a biphasic release of part of the IP3-sensitive Ca2+ pool each time.
Eberhard M, Erne P
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1995
Many secretagogues, hormones and neuro-transmitters produce their effects by a mechanism that involves a rapid increase in intracellular calcium levels. The calcium is released from intracellular vesicular stores by the action of inositol trisphosphate (IP3). IP3 is a cytosolic second messenger cleaved from phosphatidyl-inositol-4,5-diphosphate present
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Many secretagogues, hormones and neuro-transmitters produce their effects by a mechanism that involves a rapid increase in intracellular calcium levels. The calcium is released from intracellular vesicular stores by the action of inositol trisphosphate (IP3). IP3 is a cytosolic second messenger cleaved from phosphatidyl-inositol-4,5-diphosphate present
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Inositol-1,4,5-trisphosphate receptors in the vertebrate retina
Current Eye Research, 1993Evidence has shown an activation of phosphatidylinositol 4,5-bisphosphate (PIP2) specific phospholipase C (PtdIns-PLC) by light in the vertebrate retina and rod outer segments (ROS), suggesting important roles for its two metabolites, 1,2-diacylglycerol (DG) and inositol-1,4,5-trisphosphate [Ins(1,4,5)P3].
N S, Day, C A, Koutz, R E, Anderson
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Pharmacological modulators of the inositol 1,4,5-trisphosphate receptor
Neuropharmacology, 1995Elevation of cytosolic calcium concentrations, induced by many neurotransmitters, plays a crucial role in neuronal function. Some neurotransmitters produce the second messenger InsP3 which activates an intracellular calcium channel (InsP3 receptor) usually located in the endoplasmic reticulum.
F, Michelangeli +3 more
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Intrinsic inhibitor of inositol 1,4,5-trisphosphate binding
Molecular and Cellular Biochemistry, 1999Rat brain cytosol was applied to a heparin column and eluted with 0.9 M-NaCl. The total binding activity of [3H]inositol 1,4,5-trisphosphate to the eluate was increased about 6-fold compared with the original cytosol. When the eluate was mixed with a flow-through fraction from the heparin column, however, the activity returned to the original level ...
M, Hirata +3 more
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Inositol 1,4,5-trisphosphate receptors and pacemaker rhythms
Journal of Molecular and Cellular Cardiology, 2012Intracellular Ca(2+) plays an important role in the control of the heart rate through the interaction between Ca(2+) release by ryanodine receptors in the sarcoplasmic reticulum (SR) and the extrusion of Ca(2+) by the sodium-calcium exchanger which generates an inward current. A second type of SR Ca(2+) release channel, the inositol 1,4,5-trisphosphate
Ju, Yue-Kun +3 more
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Metabolism of inositol 1,4,5-trisphosphate in squid photoreceptors
Journal of Comparative Physiology B, 1990Inositol 1,4,5-trisphosphate (InsP3) is rapidly formed in squid photoreceptors in response to light, where it is converted sequentially into inositol bisphosphate (InsP2) and inositol monophosphate (InsP1). All of the InsP3 appears to be degraded to inositol 1,4-bisphosphate via an InsP3-phosphatase, which is characterized in this study.
S F, Wood, E Z, Szuts, A, Fein
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Molecular properties of inositol 1,4,5-trisphosphate receptors
Cell Calcium, 1999The receptors for the second messenger inositol 1,4,5-trisphosphate (IP3) constitute a family of Ca2+ channels responsible for the mobilization of intracellular Ca2+ stores. Three different gene products (types I-III) have been isolated, encoding polypeptides which assemble as large tetrameric structures.
S, Patel, S K, Joseph, A P, Thomas
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Calcium regulation of inositol 1,4,5-trisphosphate receptors
Cell Calcium, 2005Ca2+ exerts both a stimulatory and inhibitory effect on type-I IP3R channel activity. However, the structural determinants of Ca2+ sensing in IP3Rs are not fully understood. Previous studies by others have identified eight domains of the type-I IP3R that bind 45Ca2+ when expressed as GST-fusion proteins.
Suresh K, Joseph +2 more
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Inositol 1,4,5-Trisphosphate Receptors and Calcium Signaling
Critical Reviews™ in Neurobiology, 1996Many cellular responses to extracellular stimuli are mediated by the second messenger inositol 1,4,5-trisphosphate (InsP3). InsP3 releases Ca2+ from intracellular stores by binding to an InsP3 receptor (InSP3R), which is an InsP3-gated Ca2+ release channel.
T, Michikawa +3 more
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