Results 181 to 190 of about 58,268 (235)

An inside job: Annexin 1A-Inositol 1,4,5-trisphosphate receptor interaction conveys endoplasmic reticulum luminal Ca²⁺ sensitivity. [PDF]

Cell Calcium, 2020
Wahl AM, Yule DI.
europepmc   +1 more source

Three dimensional coupled reaction-diffusion modeling of calcium and inositol 1,4,5-trisphosphate dynamics in cardiomyocytes. [PDF]

RSC Adv, 2019
Singh N, Adlakha N.
europepmc   +1 more source

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Regulation of Inositol 1,4,5-Trisphosphate Receptors

Journal of Experimental Biology, 1993
ABSTRACT Inositol 1,4,5-trisphosphate [Ins(1,4,5)P3] is a soluble second messenger responsible for the generation of highly organized Ca2+ signals in a variety of cell types. These Ca2+ signals control many cellular responses, including cell growth, fertilization, smooth muscle contraction and secretion.
I C, Marshall, C W, Taylor
openaire   +2 more sources

Inositol 1,4,5‐Trisphosphate And Reperfusion Arrhythmias

Clinical and Experimental Pharmacology and Physiology, 2000
SUMMARY1. The present review focuses on the role of the Ca2+‐ releasing second messenger inositol 1,4,5‐trisphosphate (IP3) in initiating arrhythmias during early reperfusion following a period of myocardial ischaemia.2. Evidence for an arrhythmogenic action of IP3 was provided by studies showing a correlation between the extent of the increase in IP3 ...
E A, Woodcock, J F, Arthur, S J, Matkovich   +2 more
openaire   +2 more sources

Inositol 1,4,5-trisphosphate affinity chromatography

Biochemical and Biophysical Research Communications, 1990
Inositol 1,4,5-trisphosphate (IP3) affinity columns were made by coupling IP3 analogs to a supporting matrix. Sepharose 4B. IP3 5-phosphatase activity. IP3 3-kinase activity and IP3 binding activity from rat brain were absorbed on the IP3 columns. and were eluted by increasing KC1 concentration.
M, Hirata, Y, Watanabe, T, Ishimatsu, F, Yanaga, T, Koga, S, Ozaki   +5 more
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Characterization of D-myo-inositol 1,4,5-trisphosphate phosphatase in rat brain

Biochemical and Biophysical Research Communications, 1986
Rat brain homogenates contain significant amounts of inositol 1,4,5-trisphosphate phosphatase in both 180,000xg (60 min) particulate and supernatant fractions. As other membrane-bound enzymes (e.g.
Christophe Erneux
exaly   +1 more source

The inositol 1,4,5-trisphosphate receptors

Cell Calcium, 2005
The inositol (1,4,5)-trisphosphate receptors (InsP3R) are the intracellular calcium (Ca2+) release channels that play a key role in Ca2+ signaling in cells. Three InsP3R isoforms-InsP3R type 1 (InsP3R1), InsP3R type 2 (InsP3R2), and InsP3R type 3 (InsP3R3) are expressed in mammals.
openaire   +2 more sources

The inositol 1,4,5-trisphosphate (InsP3) receptor

The Journal of Membrane Biology, 1995
In this review, we have described the functional properties and regulation of the InsP3R. Not all aspects of InsP3R function and regulation were covered, the main focus was on the most recent and physiologically important data. Information about the structure, heterogeneity, functional properties, and regulation of the InsP3R is useful for ...
I, Bezprozvanny, B E, Ehrlich
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Inositol 1,4,5-trisphosphate receptors: Labeling the inositol 1,4,5-trisphosphate binding site with photoaffinity ligands

Biochemistry, 1993
We have photolabeled the inositol 1,4,5-trisphosphate (IP3) receptor and probed the IP3 ligand binding site using two novel photoaffinity ligands, [125I] (azidosalicyl)aminopropyl-IP3 ([125I]ASA-IP3) and [3H] (benzoyldihydrocinnamyl)aminopropyl-IP3 ([3H]BZDC-IP3).
R J, Mourey, V A, Estevez, J F, Marecek, R K, Barrow, G D, Prestwich, S H, Snyder   +5 more
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Inositol 1,4,5-Trisphosphate and Its Receptors

2012
Activation of cells by many extracellular agonists leads to the production of inositol 1,4,5-trisphosphate (IP₃). IP₃ is a global messenger that easily diffuses in the cytosol. Its receptor (IP₃R) is a Ca(2+)-release channel located on intracellular membranes, especially the endoplasmic reticulum (ER).
Jan B, Parys, Humbert, De Smedt
openaire   +2 more sources