Multiple Inositol Polyphosphate Phosphatase Compartmentalization Separates Inositol Phosphate Metabolism from Inositol Lipid Signaling [PDF]
Biomolecules, 2023 Multiple inositol polyphosphate phosphatase (MINPP1) is an enigmatic enzyme that is responsible for the metabolism of inositol hexakisphosphate (InsP6) and inositol 1,3,4,5,6 pentakisphosphate (Ins(1,3,4,5,6)P5 in mammalian cells, despite being ...
Jia Yu +6 more
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Phytase dose-dependent response of kidney inositol phosphate levels in poultry [PDF]
PLoS ONE, 2022 Phytases, enzymes that degrade phytate present in feedstuffs, are widely added to the diets of monogastric animals. Many studies have correlated phytase addition with improved animal productivity and a subset of these have sought to correlate animal ...
Colleen Sprigg +5 more
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Co-culturing experiments reveal the uptake of myo-inositol phosphate synthase (EC 5.5.1.4) in an inositol auxotroph of Saccharomyces cerevisiae [PDF]
Microbial Cell Factories, 2021 Background Myo-Inositol Phosphate Synthase (MIP) catalyzes the conversion of glucose 6- phosphate into inositol phosphate, an essential nutrient and cell signaling molecule.
Erika Steele +4 more
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Role of Inositols and Inositol Phosphates in Energy Metabolism [PDF]
Molecules, 2020 Recently, inositols, especially myo-inositol and inositol hexakisphosphate, also known as phytic acid or IP6, with their biological activities received much attention for their role in multiple health beneficial effects.
Saimai Chatree +4 more
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Nature Communications, 2021 Plants regulate phosphate homeostasis via the interaction of PHR transcription factors with SPX receptors bound to inositol pyrophosphate signaling molecules.
Rebekka Wild +2 more
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Inositol phosphate multikinase dependent transcriptional control. [PDF]
Adv Biol Regul, 2017 Production of lipid-derived inositol phosphates including IP4 and IP5 is an evolutionarily conserved process essential for cellular adaptive responses that is dependent on both phospholipase C and the inositol phosphate multikinase Ipk2 (also known as Arg82 and IPMK). Studies of Ipk2, along with Arg82 prior to demonstrating its IP kinase activity, have
Hatch AJ, Odom AR, York JD.
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Adipose Inositol Monophosphate Metabolism Is Associated with Fasting Regimen-Elicited Metabolic Benefits [PDF]
BiomoleculesIntermittent fasting (IF) has emerged as a promising strategy for managing obesity and related metabolic disorders. Although metabolic adaptations in adipose tissue during IF are well documented, the specific reprogramming of white adipose tissue (WAT ...
Chunqing Wang +6 more
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eLife, 2023 Eukaryotic cells control inorganic phosphate to balance its role as essential macronutrient with its negative bioenergetic impact on reactions liberating phosphate.
Valentin Chabert +7 more
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A Solanum tuberosum inositol phosphate kinase (StITPK1) displaying inositol phosphate–inositol phosphate and inositol phosphate–ADP phosphotransferase activities [PDF]
FEBS Letters, 2008 We describe a multifunctional inositol polyphosphate kinase/phosphotransferase from Solanum tuberosum, StITPKα (GenBank accession number: EF362784), hereafter called StITPK1. StITPK1 displays inositol 3,4,5,6‐tetrakisphosphate 1‐kinase activity: K m = 27 μM, and V max = 19 nmol min−1 mg−1.
Caddick, Samuel E. K. +5 more
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Bioactivity of Inositol Phosphates [PDF]
Molecules, 2021 Inositol phosphates (IPs) are a huge and complex family of biomolecules, important in regulating vital cellular functions, signal transduction, energy transmission, and ion channels physiology and serving as structural components of cell membranes [...]
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