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Role of Inositols and Inositol Phosphates in Energy Metabolism [PDF]
Molecules, 2020 Recently, inositols, especially myo-inositol and inositol hexakisphosphate, also known as phytic acid or IP6, with their biological activities received much attention for their role in multiple health beneficial effects.
Saimai Chatree +4 more
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Nature Communications, 2021 Plants regulate phosphate homeostasis via the interaction of PHR transcription factors with SPX receptors bound to inositol pyrophosphate signaling molecules.
Rebekka Wild +2 more
exaly +3 more sources
Nature Communications, 2020 The analysis of myo-inositol phosphates (InsPs) and myo-inositol pyrophosphates (PP-InsPs) is a daunting challenge due to the large number of possible isomers, the absence of a chromophore, the high charge density, the low abundance, and the instability ...
Danye Qiu +2 more
exaly +2 more sources
Jasmonate perception by inositol-phosphate-potentiated COI1–JAZ co-receptor
Nature, 2010 Jasmonates are a family of plant hormones that regulate plant growth, development and responses to stress. The F-box protein CORONATINE INSENSITIVE 1 (COI1) mediates jasmonate signalling by promoting hormone-dependent ubiquitylation and degradation of ...
Xu Tan, Haibin Mao, Fong-Fu Hsu
exaly +2 more sources
The Role of Inositol in Thyroid Physiology and in Subclinical Hypothyroidism Management
Frontiers in Endocrinology, 2021 Myo-Inositol (MYO) is the most abundant stereoisomer of inositols’ family, cyclic polyols with 6 hydroxyl groups. Myo-Inositol has a relevant role in thyroid function and autoimmune diseases, as a precursor of phosphoinositides that takes part in the ...
Salvatore Benvenga +7 more
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The Inositol Phosphate System—A Coordinator of Metabolic Adaptability
International Journal of Molecular Sciences, 2022 All cells rely on nutrients to supply energy and carbon building blocks to support cellular processes. Over time, eukaryotes have developed increasingly complex systems to integrate information about available nutrients with the internal state of energy ...
B. Tu‐Sekine, Sangwon Kim
semanticscholar +1 more source
The enzymatic activity of inositol hexakisphosphate kinase controls circulating phosphate in mammals
Nature Communications, 2021 Circulating phosphate levels are tightly controlled within a narrow range in mammals. By using a novel small-molecule inhibitor, we show that the enzymatic activity of inositol hexakisphosphate kinases (IP6K) is essential for phosphate regulation in vivo.
Yusuke Moritoh +7 more
semanticscholar +1 more source
eLife, 2023 Eukaryotic cells control inorganic phosphate to balance its role as essential macronutrient with its negative bioenergetic impact on reactions liberating phosphate.
Valentin Chabert +7 more
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A Solanum tuberosum inositol phosphate kinase (StITPK1) displaying inositol phosphate–inositol phosphate and inositol phosphate–ADP phosphotransferase activities [PDF]
FEBS Letters, 2008 We describe a multifunctional inositol polyphosphate kinase/phosphotransferase from Solanum tuberosum, StITPKα (GenBank accession number: EF362784), hereafter called StITPK1. StITPK1 displays inositol 3,4,5,6‐tetrakisphosphate 1‐kinase activity: K m = 27 μM, and V max = 19 nmol min−1 mg−1.
Caddick, Samuel E. K. +5 more
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Bioactivity of Inositol Phosphates [PDF]
Molecules, 2021 Inositol phosphates (IPs) are a huge and complex family of biomolecules, important in regulating vital cellular functions, signal transduction, energy transmission, and ion channels physiology and serving as structural components of cell membranes [...]
openaire +3 more sources