Inositol Pyrophosphates Inhibit Akt Signaling, Thereby Regulating Insulin Sensitivity and Weight Gain [PDF]
, 2010 Anutosh Chakraborty +14 more
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Inositol Pyrophosphate Metabolism Regulates Presynaptic Vesicle Cycling at Central Synapses
iScience, 2020 Summary: The coordination of synaptic vesicle exocytosis and endocytosis supports neurotransmitter release from presynaptic terminals. Although inositol pyrophosphates, such as 5-diphosphoinositol pentakisphosphate (5-IP7), are versatile signaling ...
Seung Ju Park +6 more
doaj
A Ca$^{2+}$ puff model based on integrodifferential equations [PDF]
arXivThe calcium (Ca$^{2+}$) signalling system is important for many cellular processes within the human body. Signals are transmitted within the cell by releasing Ca$^{2+}$ from the endoplasmic reticulum (ER) into the cytosol via clusters of Ca$^{2+}$ channels.
arxiv
The effect of point mutations on energy conduction pathways in proteins [PDF]
arXiv, 2011 Energetically responsive residues of the 173 amino acid N-terminal domain of the cardiac Ryanodine receptor RyR2 are identified by a simple elastic net model. Residues that respond in a correlated way to fluctuations of spatially neighboring residues specify a hydrogen bonded path through the protein.
arxiv
IRE1 alpha may be causing abnormal loss of p53 at post transcriptional level in chronic myeloid leukemia [PDF]
arXiv, 2017 Current treatment strategy for chronic myeloid leukemia (CML) mainly includes inhibition of tyrosine kinase activity, which has dramatically improved the prognosis of the disease but without cure. In addition some patients may become drug resistant. Thus there is still the need for other therapies to avoid resistance and if possible to cure the disease.
arxiv
Emergence of regular and complex calcium oscillations by inositol 1,4,5-trisphosphate signaling in astrocytes [PDF]
arXiv, 2017 We use tools of bifurcation theory to characterize dynamics of astrocytic~IP$_3$ and~Ca$^{2+}$ for different~IP$_3$ regimes from a mathematical point of view. We do so following a bottom-up approach, starting from a compact, well-stirred astrocyte model to first identify characteristic~IP$_3$ pathways whereby~Ca$^{2+}$ (and~IP$_3$) dynamics "bifurcate",
arxiv
Inositol Pyrophosphate Kinase Asp1 Modulates Chromosome Segregation Fidelity and Spindle Function in Schizosaccharomyces pombe [PDF]
, 2016 Boris Topolski +3 more
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Caractérisation -par spectrométrie RMN du 31P- de constituants phosphatés extraits de sols de rizières malgaches [PDF]
, 1989 Les composés phosphatés de six sols de rizières, riches en matière organique, originaires de Madagascar ont été extraits par une solution sodique. Ces composés ont été déterminés soit par une analyse chimique globale, soit par une spectrométrie RMN du ...
Fardeau, J.C. +3 more
core
Inositol pyrophosphate synthesis by diphosphoinositol pentakisphosphate kinase-1 is regulated by phosphatidylinositol(4,5)bisphosphate [PDF]
, 2018 Vasudha S. Nair +5 more
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The InsP7 phosphatase Siw14 regulates inositol pyrophosphate levels to control localization of the general stress response transcription factor Msn2 [PDF]
, 2019 Elizabeth A. Steidle +6 more
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