Results 11 to 20 of about 191 (92)

Antiaging effect of inotodiol on oxidative stress in human dermal fibroblasts

Biomedicine and Pharmacotherapy, 2022
Oxidative damage is one of the major causes of human skin aging. Inotodiol is a lanostane triterpenoid that demonstrates antiviral, anticancer, and anti-inflammatory activities. Previous studies have reported that inotodiol also has antiallergic effects.
Seung Hoon, Lee, Gun-Woo, Won, Seung-Hyeon, Choi, Mi-Yoon, Kim, Cheong-Hae, Oh, Jong-Tae, Park, Jong-Il, Park   +6 more
exaly   +3 more sources

Comparison of Bioactive Secondary Metabolites and Cytotoxicity of Extracts from Inonotus obliquus Isolates from Different Host Species [PDF]

Molecules, 2023
Inonotus obliquus, a wood-decaying mushroom, has been used as a health-promoting supplement and nutraceutical for centuries. It is a source of bioactive compounds accumulated in both the conks (pseudosclerotia/sclerotia) and the biomass obtained in vitro.
Katarzyna Sułkowska-Ziaja, Justyna Robak, Andrzej Szczepkowski, Agnieszka Gunia-Krzyżak, Justyna Popiół, Joanna Piotrowska, Bartłomiej Rospond, Agnieszka Szewczyk, Katarzyna Kała, Bożena Muszyńska   +9 more
doaj   +2 more sources

Inotodiol Attenuates Mucosal Inflammation in a Mouse Model of Eosinophilic Chronic Rhinosinusitis. [PDF]

Allergy Asthma Immunol Res
Inotodiol (22-hydroxy lanosterol), a unique component of chaga mushrooms, is believed to be a medicinal component with reported antitumor, antiviral, and anti-inflammatory properties. This study evaluated the therapeutic potential and underlying mechanisms of inotodiol in eosinophilic chronic rhinosinusitis (ECRS).An ECRS mouse model was established ...
Chung J, Im SY, Park SK, Heo DB, Sung HWJ, Ohm D, Chung EH, Park JT, Kim YM.   +8 more
europepmc   +3 more sources

Chemical Content and Cytotoxic Activity on Various Cancer Cell Lines of Chaga (Inonotus obliquus) Growing on Betula pendula and Betula pubescens [PDF]

Pharmaceuticals
Chaga mushroom (Inonotus obliquus) is a pathogenic fungus that grows mostly on birch species (Betula pendula Roth and B. pubescens Ehrh.) and has traditionally been used as an anticancer medicine.
Ain Raal, Hedi Kaldmäe, Karin Kütt, Katrin Jürimaa, Maidu Silm, Uko Bleive, Alar Aluvee, Kalev Adamson, Marili Vester, Mart Erik, Oleh Koshovyi, Khan Viet Nguyen, Hoai Thi Nguyen, Rein Drenkhan   +13 more
doaj   +2 more sources

Composition of Triterpenoids in Inonotus obliquus and Their Anti-Proliferative Activity on Cancer Cell Lines [PDF]

Molecules, 2020
The objective of this study was to determine the composition of triterpenoids in the extracts from the inner and outer parts of Inonotus obliquus and to evaluate their anti-proliferative activity against cancer cell lines (HT-29, AGS, MCF-7, and PC3 ...
Jaecheol Kim, Si Chang Yang, Ah Young Hwang, Hyunnho Cho, Keum Taek Hwang   +4 more
doaj   +2 more sources

Chaga Mushroom Triterpenoids Inhibit Dihydrofolate Reductase and Act Synergistically with Conventional Therapies in Breast Cancer [PDF]

Biomolecules
Inonotus obliquus (Chaga) is a medicinal mushroom with several pharmacological properties that is used as a tea in traditional Chinese medicine. In this study, Chaga water extract was digested in vitro to mimic the natural processing and absorption of ...
Junbiao Wang, Daniela Beghelli, Augusto Amici, Stefania Sut, Stefano Dall’Acqua, Giulio Lupidi, Diego Dal Ben, Onelia Bistoni, Daniele Tomassoni, Barbara Belletti, Sanaa Musa, Jamal Mahajna, Stefania Pucciarelli, Cristina Marchini   +13 more
doaj   +2 more sources

Biological Properties, Health Benefits and Semisynthetic Derivatives of Edible Astraeus Mushrooms (Diplocystidiaceae): A Comprehensive Review. [PDF]

Chem Biodivers
Abstract Edible Astraeus mushrooms are known for their nutritional and culinary benefits and potential therapeutic properties. However, more investigation and discussion are still needed to understand their mechanisms of action regarding observed biological activities and thorough chemical analysis of bioactive compounds.
Ung AT, Chen H.
europepmc   +2 more sources

Chaga (), a Future Potential Medicinal Fungus in Oncology? A Chemical Study and a Comparison of the Cytotoxicity Against Human Lung Adenocarcinoma Cells (A549) and Human Bronchial Epithelial Cells (BEAS-2B) [PDF]

Integrative Cancer Therapies, 2018
Background: Inonotus obliquus , also known as Chaga, is a parasitic fungus growing on birches and used in traditional medicine (especially by Khanty people) to treat various health problems.
Antoine Géry PharmD, Christelle Dubreule MSc, Véronique André PharmD, PhD, Jean-Philippe Rioult PharmD, PhD, Valérie Bouchart PhD, Natacha Heutte PhD, Philippe Eldin de Pécoulas PharmD, PhD, Tetyana Krivomaz PhD, David Garon PharmD, PhD   +8 more
doaj   +2 more sources

Beyond boundaries: Neuroprotective effects of steroids and ecdysteroids in SH-SY5Y cells - A systematic review. [PDF]

Neuroprotection
This systematic review provides valuable insights into the neuroprotective and antioxidant effects of steroids and ecdysteroids on the human neuroblastoma SH‐SY5Y cells, highlighting their potential as therapeutic agents for neurodegenerative disorders characterized by oxidative stress.
Tayeb BA, Njangiru IK, Minorics R.
europepmc   +2 more sources

Synergistic Cytotoxicity of Extracts of Chaga Mushroom and Microalgae against Mammalian Cancer Cells In Vitro. [PDF]

Oxid Med Cell Longev
Chaga mushroom (Inonotus obliquus) contains bioactive metabolites and has been used to treat various ailments, including cancer. Similarly, marine microalgae are considered a sustainable food supplement with anticancer and antioxidant properties. This study investigated the cytotoxicity of different extracts prepared from I.
Wagle S, Lee JA, Rupasinghe HPV.
europepmc   +2 more sources