Results 21 to 30 of about 191 (92)

Inotodiol protects PC12 cells against injury induced by oxygen and glucose deprivation/restoration through inhibiting oxidative stress and apoptosis

open access: yesJournal of Applied Biomedicine, 2018
Abstract Ischemic stroke is a severe cause of disability and death all over the world. To search for effective therapy for ischemic stroke, PC12 cells damaged by oxygenation and glucose deprivation/restoration were employed to assess the protective effects of inotodiol.
Yan Li, Huankai Yao
exaly   +2 more sources

Inotodiol Inhabits Proliferation and Induces Apoptosis through Modulating Expression of cyclinE, p27, bcl-2, and bax in Human Cervical Cancer HeLa Cells

open access: yesAsian Pacific Journal of Cancer Prevention, 2014
Inonotus obliquus is a medicinal mushroom that has been used as an effective agent to treat various diseases such as diabetes, tuberculosis and cancer. Inotodiol, an included triterpenoid shows significant anti-tumor effect. However, the mechanisms have not been well documented.
Li-Wei, Zhao   +4 more
exaly   +4 more sources

Julia‐Kocienski Olefination in the Synthesis of Trisubstituted Alkenes: Recent Progress

open access: yesEuropean Journal of Organic Chemistry, Volume 26, Issue 36, September 21, 2023., 2023
Julia‐Kocienski olefination has been lately often used in the preparation of trisubstituted alkenes which serve as precursors of natural products and their analogs as well of pharmaceutically interesting/biologically important compounds. Significant observations regarding the stereoselectivity of those reactions are described in this reviewing work ...
Konstantinos A. Ouzounthanasis   +2 more
wiley   +1 more source

A review of the pharmacological activities and protective effects of Inonotus obliquus triterpenoids in kidney diseases

open access: yesOpen Chemistry, 2022
Kidney diseases are common health problems worldwide. Various etiologies ultimately lead to the development of chronic kidney disease and end-stage renal disease. Natural compounds from herbs or medicinal plants are widely used for therapy and prevention
Tian Lingling   +6 more
doaj   +1 more source

Characterization and Anticancer Effects of Folate Targeted Inotodiol Liposome From Inonotus Obliquus (Chaga Mushroom) [PDF]

open access: yes, 2021
Abstract Inotodiol, one tetracyclic triterpenoid isolated from inonotus obliquus (Chaga mushroom) possess excellent anticancer, antioxidant and anti-inflammatory activities, however it has not been applied to medical use due to its low solubility and low bioavailability. Liposome as a good nanodrug carrier with EPR and good biocompatibility has
Yangpeng Lu   +7 more
openaire   +1 more source

Quality control and evaluation of Inonotus obliquus using HPLC method with novel marker compounds

open access: yesJournal of Analytical Science and Technology, 2020
Current quality control of Inonotus obliquus requires chromogen complex content limit of 10% in accordance with the State Pharmacopoeia of the Union of Soviet Socialist Republics.
Jin Hyeok Kim   +7 more
doaj   +1 more source

Inhibitory and Acceleratory Effects of Inonotus obliquus on Tyrosinase Activity and Melanin Formation in B16 Melanoma Cells

open access: yesEvidence-Based Complementary and Alternative Medicine, Volume 2014, Issue 1, 2014., 2014
The aim of the present study is to preliminarily investigate the antimelanogenesis effect of Inonotus obliquus extracts by cell‐free mushroom tyrosinase assay. It was found that petroleum ether and n‐butanol extracts might contain unknown potential tyrosinase inhibitors, while its ethyl acetate extract might contain some unknown accelerators.
Zheng-Fei Yan   +6 more
wiley   +1 more source

Mushrooms: A Potential Natural Source of Anti‐Inflammatory Compounds for Medical Applications

open access: yesMediators of Inflammation, Volume 2014, Issue 1, 2014., 2014
For centuries, macrofungi have been used as food and medicine in different parts of the world. This is mainly attributed to their nutritional value as a potential source of carbohydrates, proteins, amino acids, and minerals. In addition, they also include many bioactive metabolites which make mushrooms and truffles common components in folk medicine ...
Elsayed A. Elsayed   +4 more
wiley   +1 more source

Anti‐Inflammatory Effects of Inonotus obliquus in Colitis Induced by Dextran Sodium Sulfate

open access: yesBioMed Research International, Volume 2010, Issue 1, 2010., 2010
A total of 28 male BALB/c mice (average weight 20.7 ± 1.6 g) were divided into 4 treatment groups and fed a commercial diet (A), a commercial diet + induced colitis by dextran sodium sulfate (DSS) (B), Inonotus obliquus (IO) administration (C), and IO administration + induced colitis by DSS (D).
Se Young Choi   +7 more
wiley   +1 more source

Inotodiol suppresses proliferation of breast cancer in rat model of type 2 diabetes mellitus via downregulation of β-catenin signaling

open access: yesBiomedicine & Pharmacotherapy, 2018
Breast cancer is amongst the most common cancers causing death of women worldwide. Breast cancer occurrence is more prominent in people with diabetes. A recent trend is management of diabetes and cancer has evolved to be natural remedy including single molecule therapy or combination.
Xia, Zhang, Cuiyu, Bao, Jingping, Zhang
openaire   +2 more sources

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