Results 211 to 220 of about 150,541 (261)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Some of the next articles are maybe not open access.
Related searches:
Related searches:
Inquiry-based requirements analysis
IEEE Software, 1994This approach emphasizes pinpointing where and when information needs occur; at its core is the inquiry cycle model, a structure for describing and supporting discussions about system requirements. The authors use a case study to describe the model's conversation metaphor, which follows analysis activities from requirements elicitation and ...
Colin Potts +2 more
openaire +1 more source
Collaborating for Inquiry-Based Learning
2011This newly updated and expanded second edition of Collaborating for Inquiry-Based Learning explains effective IBL scaffolding and the school librarian's role as the lead in the collaborative process of inquiry-based teaching. Want to learn how to easily put inquiry theory into practice in your school library?
Whitney Norwood Husid +1 more
openaire +1 more source
Conceptualizing inquiry-based education in mathematics
ZDM, 2013The terms inquiry-based learning and inquiry-based education have appeared with increasing frequency in educational policy and curriculum documents related to mathematics and science education over the past decade, indicating a major educational trend. We go back to the origin of inquiry as a pedagogical concept in the work of Dewey (e.g.
Blomhøj, Morten, Artigue, Michéle
openaire +3 more sources
Inquiry-based honors physics labs
ACM SIGGRAPH 2005 Educators program on - SIGGRAPH '05, 2005We report on a new set of laboratories for our Freshman Honors Physics Course. The new labs are inquiry-based, and allow students to design, execute and analyze their own experiments. The students usually analyzed their experiments by simulating them, using realistic motion techniques in python or spreadsheets.
Peter Border, Brian Batell, B. McCoy
openaire +1 more source