Results 71 to 80 of about 2,230,593 (247)

Long-read sequencing of benthophilinae mitochondrial genomes reveals the origins of round goby mitogenome re-arrangements

Mitochondrial DNA. Part B. Resources, 2019
Genetic innovation may be linked to evolutionary success, and indeed, the invasive round goby mitochondrial genome sequence carries two novel features not previously described in Benthophilinae.
Silvia Gutnik, Jean-Claude Walser, Irene Adrian-Kalchhauser   +2 more
doaj   +1 more source

The Birth and Demise of the ISApl1-mcr-1-ISApl1 Composite Transposon: the Vehicle for Transferable Colistin Resistance

mBio, 2018
The origin and mobilization of the ~2,609-bp DNA segment containing the mobile colistin resistance gene mcr-1 continue to be sources of uncertainty, but recent evidence suggests that the gene originated in Moraxella species.
Erik Snesrud, Patrick McGann, Michael Chandler   +2 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Characterization of insertion sequence IS605 in halanaerobium hydrogeniformans [PDF]

, 2016
Insertion sequences are the smallest prokaryotic transposable elements. These genes play a significant evolutionary role by promoting genome plasticity. Insertion sequences are highly diverse elements that have largely been uncharacterized.
Sadler, Michael C.
core   +1 more source

An IS element-driven antisense RNA attenuates the expression of serotype 2 fimbriae and the cytotoxicity of Bordetella pertussis

Emerging Microbes and Infections
Insertion sequences (IS) represent mobile genetic elements that have been shown to be associated with bacterial evolution and adaptation due to their effects on genome plasticity.
Alexandre D’Halluin, Denisa Petráčková, Ivana Čurnová, Jakub Držmíšek, Jan Čapek, Peggy Bouquet, Loïc Henin, Rudy Antoine, Loïc Coutte, Camille Locht, Branislav Večerek, David Hot   +11 more
doaj   +1 more source

Conserved Patterns of Symmetric Inversion in the Genome Evolution of Bordetella Respiratory Pathogens

mSystems, 2019
Whooping cough (pertussis), primarily caused by Bordetella pertussis, has resurged in the United States, and circulating strains exhibit considerable chromosome structural fluidity in the form of rearrangement and deletion.
Michael R. Weigand, Yanhui Peng, Dhwani Batra, Mark Burroughs, Jamie K. Davis, Kristen Knipe, Vladimir N. Loparev, Taccara Johnson, Phalasy Juieng, Lori A. Rowe, Mili Sheth, Kevin Tang, Yvette Unoarumhi, Margaret M. Williams, M. Lucia Tondella   +14 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Evaluation of Drug Resistance Pattern and Molecular Detection of ISAba1 and ISAba2 in Acinetobacter baumannii Strains Isolated from Hospitalized Patients [PDF]

Journal of Mazandaran University of Medical Sciences
Background and purpose: Acinetobacter species have emerged as major causes of nosocomial infections. Acinetobacter baumannii, the most common clinical subspecies, can cause a wide range of nosocomial infections, including pneumonia, bloodstream ...
Seyed Mohammad Mahdi Mousavi, Hamid Reza Goli, Elham Amiri, Mehrdad Gholami   +3 more
doaj  

Characterization of IncC Plasmids in Enterobacterales of Food-Producing Animals Originating From China

Frontiers in Microbiology, 2020
Incompatibility group C (IncC) plasmids have received attention due to their broad host range and because they harbor key antibiotic resistance genes. Because these resistance genes can spread from food-producing animals to human, the proliferation of ...
Yu Zhang, Chang-Wei Lei, Xuan Chen, Tian-Ge Yao, Jing-Wen Yu, Wan-Long Hu, Xuan Mao, Hong-Ning Wang   +7 more
doaj   +1 more source