Results 141 to 150 of about 45,101 (293)
Novel mRNA-Engineered Fully Human CAR-T Cells Targeting AXL in Solid Tumors
BiomedicinesBackground/Objectives: The AXL receptor tyrosine kinase is a promising therapeutic target in solid tumors, yet conventional viral vector-engineered CAR-T cells face critical limitations, including risks of insertional mutagenesis and immunogenicity from ...
Bo Zou +12 more
doaj +1 more source
Retroviruses and Insertional Mutagenesis
Cold Spring Harbor Symposia on Quantitative Biology, 1985 R, Jaenisch +4 more
openaire +2 more sources
Vaspin identified as a DNA‐binding serpin with functional consequences for protease inhibition
The FEBS Journal, EarlyView.Vaspin is a serpin that is expressed in skin, adipose tissue, and liver. It binds to single‐ and double‐stranded DNA with high affinity. This binding is unaffected by mutation of the known heparin‐binding site, accelerates the inhibition of the inflammatory protease KLK7, and may contribute to vaspin's nuclear localization.
Kevin Möhlis +9 more
wiley +1 more source
The FEBS Journal, EarlyView.Zebrafish Tgds, when expressed as a recombinant protein, catalyzes the dehydration of UDP‐D‐glucose, the initial step in the formation of 6‐deoxyhexoses. Corresponding Tgds mutations found in Catel–Manzke syndrome patients lead to reduced enzymatic activity and stability.
Maria Rosaria Coppola +11 more
wiley +1 more source
Molecular genetics of development studied in the transgenic mouse. [PDF]
, 1989 Gruss, P., Westphal, H.
core +2 more sources
The FEBS Journal, EarlyView.Calcium‐binding S100 proteins are important mediators of inflammation in humans. Distant members of this family have been recently discovered in teleost fish but their resemblance to human proteins has not been explored yet. This study demonstrates that zebrafish‐specific S100i1 and S100i2 (ictacalcins) possess identical structural organization and ...
Liz Hernández +13 more
wiley +1 more source
A PCR-based method for isolation of genomic DNA flanking a known DNA sequence [PDF]
, 1999 We describe a simple PCR-based method for the isolation of genomic DNA that lies adjacent to a known DNA sequence. The method is based on the directional cloning of digested genomic DNA into the multiple cloning site of a pUC-based plasmid to generate a ...
Boulter, CA, Natarajan, D
core
The FEBS Journal, EarlyView.The regulatory subunit RIβ of protein kinase A occurs in two variants that differ at residue 268 (A268 versus R268). This seemingly small substitution significantly changes cAMP sensitivity, basal kinase activity, and the dynamic behavior of the regulatory domains.
Maximilian Wallbott +6 more
wiley +1 more source
Automodification of N‐terminal serine residues facilitates PARP2 release from DNA
The FEBS Journal, EarlyView.PARP2 is involved in detecting DNA damage and its N‐terminal role is largely unknown. Based on biochemical and biophysical data, our findings suggest that in the presence of HPF1, N‐terminal serine 8 and 73 are enriched in auto‐ADP‐ribosylation. Our results provide insight into the mechanistic role of PARP2 N‐terminus in the PARylation‐dependent ...
Saurabh Singh Dhakar +6 more
wiley +1 more source