Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Dielectric and Magnetic Spherical Hollow Shells Subjected to a dc or Low-Frequency ac Field of <i>Any</i> Spatial Form: Complete Theoretical Survey of All Scalar and Vector Physical Entities, Including the Depolarization Effect. [PDF]
Moraitis P +3 more
europepmc +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Bucket Handle, Inside-Out Medial Meniscal Repair: A Technique Video. [PDF]
Bohn C +6 more
europepmc +1 more source
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Reports from Inside the Wall: Rec Tech: A Report from Inside [PDF]
Ivers, Andrew
core +1 more source
Analysis of Heat-Mass Transfer and Exergy in Heating Process of Chilled Ready-to-Eat Foods Using High-Power Microwave Ovens. [PDF]
Klinbun J, Rattanadecho P, Klinbun W.
europepmc +1 more source
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Dataset of groundwater bacterial communities at varying distances from public cemeteries in surakarta, Indonesia. [PDF]
Rahayu T +9 more
europepmc +1 more source

