Results 61 to 70 of about 1,226,068 (263)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Taxonomic and Genomic Characterization of Brevibacillus sp. JNUCC 42 from Baengnokdam Crater Lake, Mt. Halla, and Its Cosmeceutical Potential

Applied Sciences
Jeju Island, a volcanic island located off the southern coast of the Korean Peninsula, harbors highly specialized microbial communities shaped by its unique geological and climatic diversity.
Jeong-Ha Lee, Mi-Yeon Moon, Mi-Sun Ko, Chang-Gu Hyun   +3 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Discovery of α-glucosidase inhibitors from Paenibacillus sp. JNUCC 31 via genome mining, fatty acid profiling, and in silico analysis

Scientific Reports
The increasing prevalence of type 2 diabetes has driven an increasing demand for safe and effective α-glucosidase inhibitors (AGIs). Given prior findings of α-glucosidase inhibitory activity in Paenibacillus spp., this study aims to evaluate the ...
Yang Xu, Xuhui Liang, Chang-Gu Hyun
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Building Static: Podcasting through community and care

Facts & Frictions
In this research note, the authors describe their experiences collaboratively producing Static: A Party Girl’s Memoir, an award-winning podcast that, through audio drama and interviews, tells the true story of how Ashley King lost her eyesight from ...
Meg Wilcox, Ashley King
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Navigating the intersection of mental health and kidney health: a systematic review of antidepressant safety in renal impairment

Discover Mental Health
Depression is a prevalent mental health condition that significantly impacts adults with impaired renal function, yet the safety and efficacy of antidepressants in this population remain inadequately explored.
Hooria Sarwar, Muhammad Zeshan, Najeeb Hussain, Esha Mogali, Rehan Durrani, Iana Malasevskaia   +5 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Efficacy and Safety of Ivabradine for Patients With Acute Heart Failure: Meta‐Analysis of Randomized Controlled Trials

Annals of Noninvasive Electrocardiology
Introduction The efficacy and safety of Ivabradine for patients with acute heart failure (AHF) is controversial, and there are few clinical trials addressing this topic.
Jing Han, Qi Wang, Lantian Jiang, Xia Yin   +3 more
doaj   +1 more source