Results 81 to 90 of about 3,987,444 (239)

Evolutionary cell biology: Functional insight from “Endless forms most beautiful” [PDF]

open access: yes, 2015
In animal and fungal model organisms, the complexities of cell biology have been analyzed in exquisite detail and much is known about how these organisms function at the cellular level.
Dacks, Joel B.   +4 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Sociological Insight, Volume 7 [PDF]

open access: yes, 2015
Table of Contents: From the Editor / by Jonathan Cortez (p. 1) -- ARTICLES -- “I do something different and extraordinary”: U.S. Abortion Workers and Restorative Identity Work / by Amanda Baldiga (p. 4) -- Do You Want to Be My Ally?
University of Texas at Austin
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

open access: yesFEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

InSight Aerothermal Environment Assessment [PDF]

open access: yes
The Mars Interior Exploration using Seismic Investigations, Geodesy and Heat Transport (InSight) spacecraft, which successfully touched down on the planet surface on November 26, 2018, was proposed as a near build-to-print copy of the Mars Phoenix ...
Beck, Robin A. S.   +5 more
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Action! suspense! culture! insight! : reading stories in the classroom [PDF]

open access: yes, 1983
Running title: Reading stories in the classroomAt head of title: Center for the Study of Reading.Bibliography: leaves 32-39Supported in part by the National Institute of Education under contract no.
Bruce, Bertram C.
core  

New insight into BRST anomalies in superstring theory

open access: yes, 1994
Based on the extended BRST formalism of Batalin, Fradkin and Vilkovisky, we perform a general algebraic analysis of the BRST anomalies in superstring theory of Neveu-Schwarz-Ramond. Consistency conditions on the BRST anomalies are completely solved.
Abdalla   +54 more
core   +2 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

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