Results 131 to 140 of about 2,190 (162)
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FEBS Journal, 2009
Insulin‐like peptide 3 (INSL3), which is primarily expressed in the Leydig cells of the testes, is a member of the insulin superfamily of peptide hormones. One of its primary functions is to initiate and mediate descent of the testes of the male fetus via interaction with its G protein‐coupled receptor, RXFP2.
Ross Bathgate, John D Wade, Xiao Luo
exaly +3 more sources
Insulin‐like peptide 3 (INSL3), which is primarily expressed in the Leydig cells of the testes, is a member of the insulin superfamily of peptide hormones. One of its primary functions is to initiate and mediate descent of the testes of the male fetus via interaction with its G protein‐coupled receptor, RXFP2.
Ross Bathgate, John D Wade, Xiao Luo
exaly +3 more sources
Annals of the New York Academy of Sciences, 2009
The use of radioisotope‐labeled peptides and proteins in bioassays is diminishing as a consequence of the emergence of fluorescent lanthanide‐labeled probes. We describe a simple, single‐step labeling of synthetic human insulin‐like peptide 3 (INSL3) with a commercially available activated europium chelator.
Fazel, Shabanpoor +4 more
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The use of radioisotope‐labeled peptides and proteins in bioassays is diminishing as a consequence of the emergence of fluorescent lanthanide‐labeled probes. We describe a simple, single‐step labeling of synthetic human insulin‐like peptide 3 (INSL3) with a commercially available activated europium chelator.
Fazel, Shabanpoor +4 more
openaire +2 more sources
Chemical synthesis and biological activity of rat INSL3
Journal of Peptide Science, 2001AbstractThe recently identified protein, insulin 3 (INSL3), has structural features that make it a bona fide member of the insulin superfamily. Its predicted amino acid sequence contains the classic two‐peptide chain (A‐ and B‐) structure with conserved cysteine residues that results in a disulphide bond disposition identical to that of insulin ...
K J, Smith +8 more
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INSL3/RXFP2 Signaling in Testicular Descent [PDF]
Annals of the New York Academy of Sciences, 2009 Mutations of the insulin-like peptide 3 (INSL3) hormone or its receptor, RXFP2, cause intraabdominal cryptorchidism in male mice. Specific RXFP2 expression in mouse gubernacula was detected at embryonic day 14.5 and markedly increased after birth in the developing cremaster muscle, as well as in the epididymis and testicular Leydig and germ cells ...
Alberto Ferlin +2 more
exaly +6 more sources
Genetic Targeting of Relaxin and Insl3 Signaling in Mice
Annals of the New York Academy of Sciences, 2005Abstract: We studied ligand‐receptor interactions between relaxin (RLN), insulin‐like 3 peptide (INSL3), and LGR7 and LGR8 receptors. The phenotypic effects of deficiency for Lgr7 and Lgr8 receptors, transgenic overexpression of Rln1 and Insl3, and different combinations of these mutations in mice were analyzed.
Shu, Feng +3 more
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The “Hot Wires” of the Relaxin‐Like Factor (Insl3)
Annals of the New York Academy of Sciences, 2009The discovery of the total separation of receptor‐binding and signal‐generating regions of the relaxin‐like factor (RLF) has provided an opportunity to investigate the mechanism of transmembrane signaling. The receptor‐binding residues of RLF are in the B chain of the two‐chain molecule and extend from the midregion of the central helix to the ...
Christian, Schwabe, Erika E, Büllesbach
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Constitutive regulation of the Insl3 gene in rat Leydig cells
Molecular and Cellular Endocrinology, 2005Insulin-like factor 3 (Insl3) is a major new product of the Leydig cells in all mammalian species so far examined. The rat Insl3 gene is encoded by two exons in close juxtaposition to the Jak3 gene. Using RT-PCR analysis we now show that in the rat testis it is expressed as both major and minor splice variants, the former encoding the normal protein ...
Sadeghian, Helen +4 more
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Testicular descent: INSL3, testosterone, genes and the intrauterine milieu
Nature Reviews Urology, 2011Complete testicular descent is a sign of, and a prerequisite for, normal testicular function in adult life. The process of testis descent is dependent on gubernacular growth and reorganization, which is regulated by the Leydig cell hormones insulin-like peptide 3 (INSL3) and testosterone.
Bay, Katrine +3 more
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Absence of mutations involving the INSL3 gene in human idiopathic cryptorchidism. [PDF]
Molecular Human Reproduction, 2000 The aetiology of cryptorchidism is for the most part unknown and appears to be multifactorial. Recently, a product of Leydig cells termed Leydig insulin-like hormone (INSL3) has been proposed as a putative trophic hormone of the first part of descent.
Kenneth McElreavey +2 more
exaly +4 more sources
INSL3 in the benign hyperplastic and neoplastic human prostate gland
International Journal of Oncology, 2005The human prostate gland is a well known source of H1 and H2 relaxin but information is lacking on the expression and potential role of the INSL3 peptide hormone within the prostate gland. In the present study we have investigated the expression of human INSL3 in patients with benign prostate hyperplasia (BPH), prostate intraepithelial neoplasia (PIN ...
Thomas, Klonisch +11 more
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