Results 121 to 130 of about 2,190 (162)
Functional Characterization of <i>IGF2BP1</i>, <i>CDC25A</i>, and <i>RXFP2</i> Genes: Implications for Ovarian Function and Reproductive Regulation in Goats. [PDF]
Animals (Basel)Yang H +8 more
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Annals of the New York Academy of Sciences, 2009
Insulin-like factor 3 (INSL3) is produced primarily by testicular Leydig cells and acts by binding to its specific G-protein-coupled receptor, RXFP2 (relaxin family peptide 2). INSL3 is involved in testicular descent during fetal development, and mutations in the INSL3 and RXFP2 genes cause cryptorchidism.
Alberto Ferlin +2 more
exaly +7 more sources
Insulin-like factor 3 (INSL3) is produced primarily by testicular Leydig cells and acts by binding to its specific G-protein-coupled receptor, RXFP2 (relaxin family peptide 2). INSL3 is involved in testicular descent during fetal development, and mutations in the INSL3 and RXFP2 genes cause cryptorchidism.
Alberto Ferlin +2 more
exaly +7 more sources
Characterization of the Rat INSL3 Receptor
Annals of the New York Academy of Sciences, 2005Abstract: Human LGR8, initially discovered as a low‐affinity relaxin receptor, has now been characterized as the INSL3 receptor. To investigate LGR8 function in the rat, an LGR8 ortholog was identified in the rat genome, and the full‐length sequence was cloned and expressed. Rat LGR8 bound INSL3 with high affinity, clearly demonstrating that it is the
Daniel J. Scott +2 more
exaly +3 more sources
INSL3 has tumor-promoting activity in thyroid cancer [PDF]
International Journal of Cancer, 2010 AbstractThe functional role of INSL3 and its receptor RXFP2 in carcinogenesis is largely unknown. We have previously demonstrated (pro‐)cathepsin‐L as a target of INSL3 in human thyroid cancer cells facilitating penetration of tumor cells through elastin matrices.
Alexander Agoulnik +2 more
exaly +3 more sources
Clinical value of INSL3 in the diagnosis and development of diabetic nephropathy [PDF]
Journal of Clinical Laboratory Analysis, 2021 AbstractBackgroundInsulin‐like factor 3 (INSL3) was stated to be an essential regulator in many diseases. This present study aimed to explore the underlying mechanisms of INSL3 in diabetic nephropathy (DN).MethodsThe serum samples were obtained from 121 DN patients, 67 T2DM patients, and 44 healthy controls. Twenty SD rats were used to establish the DN
Jing Zhu
exaly +3 more sources
INSL3 in the muscolo-skeletal system
Molecular and Cellular Endocrinology, 2019Bone and skeletal muscle are currently considered a unified functional unit, showing complementary regulation at mechanical, biochemical, paracrine and metabolic levels. This functional unit undergoes a central hormonal regulation which is mainly ascribed to sex steroids and, in particular, androgens.
De Toni, Luca +4 more
openaire +2 more sources
The role of the testicular factor INSL3 in establishing the gonadal position
Molecular and Cellular Endocrinology, 2000 INSL3, also designated Leydig insulin-like (Ley I-L) or relaxin-like factor (RLF), belongs to the insulin-like hormone superfamily. It is expressed in pre- and postnatal Leydig cells of the testis and in postnatal theca cells of the ovary. This sexual dimorphic pattern of INSL3 expression during development led us to suggest that the INSL3 factor could
Ibrahim Adham
exaly +5 more sources
Cryptorchidism in mice mutant for Insl3
Nature Genetics, 1999Impaired testicular descent (cryptorchidism) is one of the most frequent congenital abnormalities in humans, involving 2% of male births. Cryptorchidism can result in infertility and increases risk for development of germ-cell tumours. Testicular descent from abdomen to scrotum occurs in two distinct phases: the trans-abdominal phase and the inguino ...
S, Nef, L F, Parada
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