Results 71 to 80 of about 877,036 (297)
mBioDNA polymerase ε (Polε) is an essential replicative polymerase consisting of Pol2, Dpb2, Dpb3, and Dpb4 subunits and has not been explored in the pathogenic yeast Candida albicans. C. albicans is accountable for >40% of deaths due to systemic candidiasis
Bhabasha Gyanadeep Utkalaja +4 more
doaj +1 more source
Numerical investigation of plasma-driven superradiant instabilities [PDF]
, 2020 Alexandru Dima, Enrico Barausse
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A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy
Molecular Oncology, EarlyView.Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti +3 more
wiley +1 more source
Problems of Atomic Science and Technology, 2019 The dynamics of the oscillator system is investigated. The conditions under which this dynamics becomes unstable are determined. In particular, it is shown that plasma in constant magnetic field becomes unstable if its density exceeds a certain critical value. In this case, instability develope (oscillatory instability).
openaire +2 more sources
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Experimental Investigation of Flow Domain Division in Beds Packed with Different Sized Particles
Energies, 2017 Seepage in a medium packed with particles of variable granular size can be seen in many fields of engineering applications. Due to the relative complex spatial aspect of pore geometry, there are notable differences in the critical parameters of flow ...
Xin Yang +3 more
doaj +1 more source
Mrc1 and Tof1 prevent fragility and instability at long CAG repeats by their fork stabilizing function [PDF]
, 2018 Lionel Gellon +5 more
openalex +1 more source
BRAF-V600E and microsatellite instability prediction through CA-19-9/CEA ratio in patients with colorectal cancer [PDF]
, 2020 Pashtoon Murtaza Kasi +6 more
openalex +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source