Results 71 to 80 of about 60,618 (280)

Study on the Assessment of STEM Instructional Design Plan Based on Information Flows

Journal of Learning for Development
In recent years, the growing incidence of blended and online learning has highlighted instructional design concerns, especially STEM instructional design.
Lanqin Zheng, Zichen Huang, Yang Liu
doaj   +1 more source

Factors Affecting Learning in Instructional Design Model: Medical Students’ Viewpoint in Fasa University of Medical Sciences [PDF]

مجله ایرانی آموزش در علوم پزشکی, 2013
Introduction: Instructional technology is used to decrease educational problems nowadays. The first step for using this technology is designing. To apply a design, a model is used.
Zohreh Makoolati, Majid Naghdi, Mohammad mehdi Naghizadeh jahromi, Mahboobeh Bahar   +3 more
doaj  

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Usability in learning management systems: A mixed-method analysis

International Journal of Pioneering Technology and Engineering
Usability analysis in software has a critical role in creating useful products for users and obtaining the necessary feedback. Learning Management Systems (LMSs) are among the most frequently used software in distance education.
Pembe Pelin Koca, Hakan Özcan
doaj   +1 more source

Here and There, Now and Then: Creativity, Design and Instruction for Hybrid Environments [PDF]

, 2022
Daragh Byrne, Dina EL-Zanfaly, Daphne Peters, Peter Scupelli, Daniel Rosenberg Munoz   +4 more
openalex   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Mechanism underlying revetment effects on the spatial distribution of nitrogen removal and N2O emissions in riparian zones at summer

Journal of Hydrology: Regional Studies
Study Region, Shanghai, China, Study FocusUrban riparian zones can mitigate or even control nitrogen pollution in rivers through nitrification and denitrification processes. However, these processes also produce N2O, a potent greenhouse gas.
Zihao Man, Changkun Xie, Ruiyuan Jiang, Jin Wang, Yanting Zhang, Shengquan Che   +5 more
doaj   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Gender disparities in K-12 computer science education: Status, contributing factors, and instructional approaches

Computers and Education Open
This study conducts a systematic review of the literature to investigate gender disparities in K-12 computer science (CS) education. We selected articles published in peer-reviewed journals that focused on both cognitive and affective aspects of ...
Kyungbin Kwon, Sang Joon Lee, Keunjae Kim   +2 more
doaj   +1 more source