Results 71 to 80 of about 595,744 (272)

Model-driven description and validation of composite learning content [PDF]

, 2010
Authoring of learning content for courseware systems is a complex activity requiring the combination of a range of design and validation techniques. We introduce the CAVIAr courseware models allowing for learning content description and validation. Model-
Melia, Mark, Pahl, Claus
core   +1 more source

The impact of goal orientation, self-reflection and personal characteristics on the acquisition of oral presentation skills [PDF]

, 2009
Although many educators help others to develop oral presentation skills, little research is available to direct the instructional design activities of these educators.
Degrez, Luc, Roozen, Irène, Valcke, Martin   +2 more
core   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Metacognition and transfer within a course or instructional design rules and metacognition [PDF]

, 2006
A metacognitive strategy for doing research, included transfer, was taught in a course of nine afternoons. The success of this course raised some questions. How do the students learn? How does metacognition play a role?
Vos, Henk
core   +1 more source

Implementation of Sparkol Videoscribe Physics-based Learning Media Pace to Improve Students' Analytical Skills [PDF]

, 2020
Learning media can determine the quality of education, one of the digital media revolution with the development era 4.0. So that the required media interesting and appropriate media learning needs.
Kurniawan, E. S. (Eko), Pratiwi, U. (Umi), Setyaningrum, R. A. (Resti)   +2 more
core  

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

DESAIN PEMBELAJARAN KIMIA BERMUATAN NILAI PADA SUBTOPIK PERKEMBANGAN MODEL ATOM [PDF]

, 2014
Penelitian yang berjuduldesainpembelajarankimiabermuatannilaipadasubtopikperkembangan model atomdilakukanuntukmembuatdesainpembelajarankimiabermuatannilaipadasubtopikperkembangan model atom yang dituangkandalambentukRPPdanperangkatnya (LKS ...
Wulandari, Rina
core  

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

From co-design to co-teaching: a comprehensive approach to an integrated AI curriculum in middle school STEM education

Smart Learning Environments
Co-design and co-teaching are practical approaches for teachers with varying experiences to get involved in integrating AI curriculum with STEM subjects.
Keunjae Kim, Kyungbin Kwon
doaj   +1 more source

Exploring Small Group Analysis of Instructional Design Cases in Online Learning Environments [PDF]

, 2017
The case-based approach is a constructivist instructional strategy that helps students apply their emerging knowledge by studying design problems in authentic real-world situations.
Trespalacios, Jesus
core   +2 more sources