Results 71 to 80 of about 9,475,400 (288)
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Tools of the Trade: The Role of Perceptions and Context in Designing and Developing Instructional Learning Aids [PDF]
, 2013 The Journal of Applied Instructional Design is available at http://www.jaidpub.org.Design principles, theories and artifacts from instruction in many fields have been analyzed from various perspectives.
Hardre, Patricia, Kollmann, Sherry
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Smart Learning EnvironmentsCo-design and co-teaching are practical approaches for teachers with varying experiences to get involved in integrating AI curriculum with STEM subjects.
Keunjae Kim, Kyungbin Kwon
doaj +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Perspective: the gist of public tender for service design [PDF]
, 2018 Governments around the world are increasingly formalising design as an innovative approach to renew public services. In this development, the capabilities of external service design consultancies often play an important part, which calls for new insights
Person, Oscar +3 more
core +1 more source
The Implication of Lifelong Learning on Instructional Design
, 2013 Lifelong learning has become a hot topic in recent years. More and more people accept the concept and become lifelong learners. Instructional design has been used to solve educational problems.
李麗君
core +1 more source
Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy
Molecular Oncology, EarlyView.We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen +19 more
wiley +1 more source
Instructional technology research, design and development: lessons from the field
, 2012 This book is about design and development in Instructional Technology Design and development research (Richey & Klein, 2007), or was formerly known as developmental research (Richey, Klein & Nelson, 2004) is an emerging form of research in the field of
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Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Authentic E-Learning in higher education: Design principles for authentic learning environments and tasks [PDF]
, 2006 With many learners failing to engage with didactic and outmoded instructional methods, and unwilling to use technology that simply replicates the one-way transfer of information from teacher to student, authentic learning designs have the potential to ...
Herrington, J.
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