Results 61 to 70 of about 2,342,791 (305)
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
FUNCTION OF FEEDBACK AND INSTRUCTIONS PRESENCE OR ABSENCE IN DESCRIPTION ELABORATION ON CONDITIONAL DISCRIMINATION TASKS [PDF]
Acta Colombiana de Psicología, 2007 The function of rules and instructions to facilitate, maintain or modify the behaviour of individuals has been widely explored in a great variety of tasks.
Guerrero Radillo, Alejandra Paola +1 more
doaj
Instruction Tuning With Loss Over Instructions
Advances in Neural Information Processing Systems 37NeurIPS 2024.
Zhengyan Shi +5 more
openaire +4 more sources
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Secourir un train en panne : limites et difficultés à l’écriture des règles de sécurité
Activités, 2012 Risk-prone organisations issue regulations to ensure the stability and safety of the socio-technical system. However, the tendency to over-regulate has its limitations.
Alexandre Largier, Nicolas Lot
doaj +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Instrukce pro hornolužické zeměpanské úředníky v 16. století | Instructions for Upper Lusatian officials in the 16th century [PDF]
Historie - Otázky - Problémy, 2019 The author focuses on the creation of the monarchical administration in Upper Lusatia as one of the Lands of the Bohemian Crown, after the mid-16th century, when significant changes in this area were made.
Tomáš Velička
doaj
Актуальні питання суспільних наук та історії медицини, 2017 Антонюк Я Постсуицидальный синдром среди идейных фанатиков (на материалах подполья ОУН Волыни). Анализируя постсуицидальный синдром трех рассмотренных подпольщиков ОУН Волыни, можно сделать вывод, что каждый раз он имел существенные различия.
Ярослав АНТОНЮК
doaj +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source