Results 61 to 70 of about 4,021,411 (294)
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
Psicologia: Teoria e PesquisaRESUMOPara verificar os efeitos da história comportamental e de instruções sobre a aquisição e a resistência à extinção, 15 universitários foram distribuídos em três grupos. Na Fase 1, o Grupo 1 foi exposto a aumentos graduais nos valores dos componentes
Celso Apparecido Athayde Neto +2 more
doaj +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Comparison Between Guided and Non-Guided Homework as a Tool for Learning Electric Circuit Theory
Education SciencesThe present work highlights the differences between two simultaneous groups taking the electric circuit theory course. Both groups were given the same non-mandatory homework prior to the evaluation; however, the instructions provided to the groups ...
Rafael Diez +2 more
doaj +1 more source
Instrukce pro hornolužické zeměpanské úředníky v 16. století | Instructions for Upper Lusatian officials in the 16th century [PDF]
Historie - Otázky - Problémy, 2019 The author focuses on the creation of the monarchical administration in Upper Lusatia as one of the Lands of the Bohemian Crown, after the mid-16th century, when significant changes in this area were made.
Tomáš Velička
doaj