Results 61 to 70 of about 1,971,504 (262)
Актуальні питання суспільних наук та історії медицини, 2017 Антонюк Я Постсуицидальный синдром среди идейных фанатиков (на материалах подполья ОУН Волыни). Анализируя постсуицидальный синдром трех рассмотренных подпольщиков ОУН Волыни, можно сделать вывод, что каждый раз он имел существенные различия.
Ярослав АНТОНЮК
doaj +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Psicologia: Teoria e PesquisaRESUMOPara verificar os efeitos da história comportamental e de instruções sobre a aquisição e a resistência à extinção, 15 universitários foram distribuídos em três grupos. Na Fase 1, o Grupo 1 foi exposto a aumentos graduais nos valores dos componentes
Celso Apparecido Athayde Neto +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Comparison Between Guided and Non-Guided Homework as a Tool for Learning Electric Circuit Theory
Education SciencesThe present work highlights the differences between two simultaneous groups taking the electric circuit theory course. Both groups were given the same non-mandatory homework prior to the evaluation; however, the instructions provided to the groups ...
Rafael Diez +2 more
doaj +1 more source