Results 71 to 80 of about 1,971,504 (262)
Instrukce pro hornolužické zeměpanské úředníky v 16. století | Instructions for Upper Lusatian officials in the 16th century [PDF]
Historie - Otázky - Problémy, 2019 The author focuses on the creation of the monarchical administration in Upper Lusatia as one of the Lands of the Bohemian Crown, after the mid-16th century, when significant changes in this area were made.
Tomáš Velička
doaj
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Ciencia y Enfermería, 2003 Este texto tem como objetivo mostrar a contribuição da tríade ensino, assistência de enfermagem e pesquisa qualitativa na identificação de dados que direcionam o cuidado cultural às mulheres moradoras em uma favela da cidade de São Paulo, Brasil ...
NEIDE DE SOUZA PRAÇA
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Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Components of abstracts in materials science and technology
Knjižnica, 2009 We investigated the structure of abstracts in Slovenian and international journals in the field of materials and technology. The aim of the study was to analyze the adherence of the abstracts published in Materials and Technology (MIT) and Materials ...
Nina Jamar, Alenka Šauperl
doaj +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Obediência infantil: conceituação, medidas comportamentais e resultados de pesquisas
Psicologia: Teoria e PesquisaA obediência infantil a instruções parentais é um tema amplamente abordado na literatura clínica comportamental. No entanto, há poucos estudos que quantifiquem níveis de obediência em crianças de idades específicas, dificultando o trabalho dos clínicos ...
Annie Catharine Wielewicki Bueno +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source