Results 1 to 10 of about 2,129,772 (314)

Use of the SGLT2 inhibitor canagliflozin for control of refractory equine hyperinsulinemia and laminitis [PDF]

Open Veterinary Journal, 2022
Background: Hyperinsulinemia associated with pituitary pars intermedia dysfunction (PPID) and/or equine metabolic syndrome (EMS) is well documented to put horses at high risk of laminitis.
Eleanor M. Kellon, Kathleen M. Gustafson
doaj   +1 more source

Differentiation of human subcutaneous adipocytes and measurement of lipolytic function induced by GIP or LY3437943

STAR Protocols, 2023
Summary: Human subcutaneous adipocytes are an attractive therapeutic target in regulating overall physiological homeostasis. However, the differentiation of primary human adipose-derived models remains challenging.
Ajit Regmi, William Roell
doaj   +1 more source

Molecular and Cellular Bases of Lipodystrophy Syndromes

Frontiers in Endocrinology, 2022
Lipodystrophy syndromes are rare diseases originating from a generalized or partial loss of adipose tissue. Adipose tissue dysfunction results from heterogeneous genetic or acquired causes, but leads to similar metabolic complications with insulin ...
Jamila Zammouri, Camille Vatier, Camille Vatier, Emilie Capel, Martine Auclair, Caroline Storey-London, Elise Bismuth, Héléna Mosbah, Héléna Mosbah, Bruno Donadille, Bruno Donadille, Sonja Janmaat, Sonja Janmaat, Bruno Fève, Bruno Fève, Isabelle Jéru, Isabelle Jéru, Isabelle Jéru, Corinne Vigouroux, Corinne Vigouroux, Corinne Vigouroux   +20 more
doaj   +1 more source

Hypertriglyceridemia in equines with refractory hyperinsulinemia treated with SGLT2 inhibitors

Open Veterinary Journal, 2023
Background: Sodium-Glucose CoTransporter-2 [SGLT2] inhibitors, the -flozin group of drugs, which block glucose reuptake in the renal proximal tubule, are being increasingly used off-label to treat horses with refractory hyperinsulinemia. After two years
Eleanor M. Kellon, Kathleen M. Gustafson
doaj   +1 more source

Pregnancy in Women With Monogenic Diabetes due to Pathogenic Variants of the Glucokinase Gene: Lessons and Challenges

Frontiers in Endocrinology, 2022
Heterozygous loss-of-function variants of the glucokinase (GCK) gene are responsible for a subtype of maturity-onset diabetes of the young (MODY). GCK-MODY is characterized by a mild hyperglycemia, mainly due to a higher blood glucose threshold for ...
José Timsit, José Timsit, José Timsit, Cécile Ciangura, Cécile Ciangura, Cécile Ciangura, Danièle Dubois-Laforgue, Danièle Dubois-Laforgue, Danièle Dubois-Laforgue, Danièle Dubois-Laforgue, Cécile Saint-Martin, Cécile Saint-Martin, Christine Bellanne-Chantelot, Christine Bellanne-Chantelot, Christine Bellanne-Chantelot   +14 more
doaj   +1 more source

Possible dysmetabolic hyperferritinemia in hyperinsulinemic horses [PDF]

Open Veterinary Journal, 2019
Background: Hyperinsulinemia associated with equine metabolic syndrome (EMS) and pituitary pars intermedia dysfunction (PPID) is a risk factor for laminitis.
Eleanor M. Kellon, Kathleen M. Gustafson
doaj   +1 more source

Dunnigan lipodystrophy syndrome: French National Diagnosis and Care Protocol (PNDS; Protocole National de Diagnostic et de Soins)

Orphanet Journal of Rare Diseases, 2022
Dunnigan syndrome, or Familial Partial Lipodystrophy type 2 (FPLD2; ORPHA 2348), is a rare autosomal dominant disorder due to pathogenic variants of the LMNA gene. The objective of the French National Diagnosis and Care Protocol (PNDS; Protocole National
H. Mosbah, B. Donadille, C. Vatier, S. Janmaat, M. Atlan, C. Badens, P. Barat, S. Béliard, J. Beltrand, R. Ben Yaou, E. Bismuth, F. Boccara, B. Cariou, M. Chaouat, G. Charriot, S. Christin-Maitre, M. De Kerdanet, B. Delemer, E. Disse, N. Dubois, B. Eymard, B. Fève, O. Lascols, P. Mathurin, E. Nobécourt, A. Poujol-Robert, G. Prevost, P. Richard, J. Sellam, I. Tauveron, D. Treboz, B. Vergès, V. Vermot-Desroches, K. Wahbi, I. Jéru, M. C. Vantyghem, C. Vigouroux   +36 more
doaj   +1 more source

Insulin-Like Growth Factor II (IGF-II) Is More Potent Than IGF-I in Stimulating Cortisol Secretion from Cultured Bovine Adrenocortical Cells: Interaction with the IGF-I Receptor and IGF-Binding Proteins [PDF]

, 1995
Although the stimulating effect of insulin-like growth factor I (IGF-I) on adrenal steroidogenesis has been well established, the role of IGF-II in the adult adrenal gland remains unknown.
Engelhardt, Dieter, Fottner, Christian, Simmler, Pia, Weber, Matthias M.   +3 more
core   +1 more source

The effects of peripheral and central high insulin on brain insulin signaling and amyloid-β in young and old APP/PS1 mice [PDF]

, 2016
Hyperinsulinemia is a risk factor for late-onset Alzheimer's disease (AD). In vitro experiments describe potential connections between insulin, insulin signaling, and amyloid-β (Aβ), but in vivo experiments are needed to validate these relationships ...
Caesar, Emily E, Holtzman, David M, Jiang, Hong, Keyser, Jennifer, Koscal, Lauren J, Macauley, Shannon L, Moritz, Will, Robinson, Grace O, Roh, Joseph, Stanley, Molly   +9 more
core   +2 more sources

Class-switched anti-insulin antibodies originate from unconventional antigen presentation in multiple lymphoid sites [PDF]

, 2016
Autoantibodies to insulin are a harbinger of autoimmunity in type 1 diabetes in humans and in non-obese diabetic mice. To understand the genesis of these autoantibodies, we investigated the interactions of insulin-specific T and B lymphocytes using T ...
Acevedo-Suárez, Achenbach, Adelstein, Akashi, Batista, Bodansky, Cooke, Crotty, Dean, Emil R. Unanue, Ferris, Gagnerault, Garside, Gitlin, Glazier, Goodnow, Greeley, Gretz, Harbers, Henry, Henry, Henry-Bonami, Hoppu, Hu, Hulbert, Höglund, James W. Thomas, Kendall, Kendall, Kenefeck, Levisetti, Linterman, Mariño, Mohan, Mohan, Mohan, Nakayama, Noorchashm, Okada, Pape, Rasio, Reinhardt, Rojas, Roozendaal, Serreze, Silva, Takahashi, Ueno, Unanue, Victora, Victora, Vinuesa, Vomund, Williams, Xiaoxiao Wan, Yang, Zhang, Zhang, Zikherman, Zotos   +59 more
core   +2 more sources