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New Insulins, Biosimilars, and Insulin Therapy [PDF]
Diabetes Technology & Therapeutics, 2016 Exogenous insulin has greatly changed the outlook for patients with diabetes ever since its discovery and isolation. Yet, serious complications can result as patients experience both hyperglycemic and hypoglycemic states, even when they strictly follow an insulin regimen. Several chemically or genetically modified insulins have been developed that tune
Lutz Heinemann +2 more
openaire +13 more sources
Automated Insulin Delivery for Type 1 Diabetes Mellitus Patients using Gaussian Process-based Model Predictive Control [PDF]
American Control Conference (ACC) 2019, 2021 The human insulin-glucose metabolism is a time-varying process, which is partly caused by the changing insulin sensitivity of the body. This insulin sensitivity follows a circadian rhythm and its effects should be anticipated by any automated insulin delivery system. This paper presents an extension of our previous work on automated insulin delivery by
arxiv +1 more source
European Journal of Endocrinology, 1999 The pathogenesis of type 2 diabetes is characterized by insulin resistance, primarily in skeletal muscle, fat and liver, and a relative failure of the pancreatic b-cell (1, 2). Considerable controversy surrounds the issue of which of these deficiencies is the primary cause of diabetes.
openaire +3 more sources
Insulin Resistance: From Mechanisms to Therapeutic Strategies
Diabetes & Metabolism Journal, 2021 Insulin resistance is the pivotal pathogenic component of many metabolic diseases, including type 2 diabetes mellitus, and is defined as a state of reduced responsiveness of insulin-targeting tissues to physiological levels of insulin.
Shin-Hae Lee, Shi-Young Park, C. Choi
semanticscholar +1 more source
New England Journal of Medicine, 1993 BACKGROUND Long-term microvascular and neurologic complications cause major morbidity and mortality in patients with insulin-dependent diabetes mellitus (IDDM).
Diabetes Control +8 more
semanticscholar +1 more source
Temporal patterns in insulin needs for Type 1 diabetes [PDF]
JMIRx Med 5(1):e44384 (2024), 2022 Type 1 Diabetes (T1D) is a chronic condition where the body produces little or no insulin, a hormone required for the cells to use blood glucose (BG) for energy and to regulate BG levels in the body. Finding the right insulin dose and time remains a complex, challenging and as yet unsolved control task.
arxiv +1 more source
Journal of Clinical Investigation, 2003 Insulin resistance arises from the inability of insulin to act normally in regulating nutrient metabolism in peripheral tissues. Increasing evidence from human population studies and animal research has established correlative as well as causative links ...
Haiyan Xu +10 more
semanticscholar +1 more source
Biosimilar Insulin and Insulin Antibodies [PDF]
Journal of Diabetes Science and Technology, 2013 The introduction of biosimilar insulins in regulated markets is anticipated to happen in the next few years.1,2 However, biosimilar insulins are already on the market in a number of countries with little or no guidelines for approval of biosimilars and where approval is relatively easy to obtain.
David R. Owens, Lutz Heinemann
openaire +2 more sources
Security, extensibility, and redundancy in the Metabolic Operating System [PDF]
arXiv, 2023 People living with Type 1 Diabetes (T1D) lose the ability to produce insulin naturally. To compensate, they inject synthetic insulin. One common way to inject insulin is through automated insulin delivery systems, which use sensors to monitor their metabolic state and an insulin pump device to adjust insulin to adapt.
arxiv
Comparative Analysis of Kinetic Realizations of Insulin Signaling [PDF]
arXiv, 2023 Several studies have developed dynamical models to understand the underlying mechanisms of insulin signaling, a signaling cascade that leads to the translocation of glucose, the human body's main source of energy. Fortunately, reaction network analysis allows us to extract properties of dynamical systems without depending on their model parameter ...
arxiv