Results 31 to 40 of about 7,203,866 (304)

Cancer risk associated with insulin glargine among adult type 2 diabetes patients--a nationwide cohort study. [PDF]

PLoS ONE, 2011
BACKGROUND: Preclinical and observational studies raise the concern about the safety of insulin glargine in terms of cancer initiation and promotion.
Chia-Hsuin Chang, Sengwee Toh, Jou-Wei Lin, Shu-Ting Chen, Chuei-Wen Kuo, Lee-Ming Chuang, Mei-Shu Lai   +6 more
doaj   +1 more source

Improvement of insulin response in the streptozotocin model of insulin-dependent diabetes mellitus. Insulin response with and without a long-acting insulin treatment

Animal, 2009
Streptozotocin-induced diabetes mellitus (STZ-DM) in rats is a model of type 1 diabetes, which is commonly used to study diabetes, but differs from human diabetic pathophysiology in its insulin resistance. An STZ-DM rat can be administered five times the
L. Nordquist, M. Sjöquist
doaj   +1 more source

Role of Myotonic Dystrophy Protein Kinase [DMPK] in Glucose Homeostasis and Muscle Insulin Action [PDF]

, 2007
Myotonic dystrophy 1 (DM1) is caused by a CTG expansion in the 3′-unstranslated region of the DMPK gene, which encodes a serine/threonine protein kinase. One of the common clinical features of DM1 patients is insulin resistance, which has been associated
Liesa Marc, Ciaraldi, Theodore P, Martí, Luc, Ciaraldi, Theodore P., Palacin, Manuel, Catalucci, Daniele, Wolfgang H Dillmann, Esther Llagostera, Perla Kaliman, Catalucci Daniele, Camps, Marta, Reddy, Sita, Gomis, Ramon, 1946-, Luc Marti, Llagostera Martín, Esther, Antonio Zorzano, Ciaraldi Theodore P., Dillmann, Wolfgang H, Llagostera Esther, Gomis Ramon, Reddy Sita, Camps Marta, Dillmann, Wolfgang H., Kaliman Perla, Sita Reddy, Kaliman, Perla, Ruiz-Lozano Pilar, Llagostera, Esther, Richard Kondo, Ruiz-Lozano, Pilar, Zorzano Olarte, Antonio, Manuel Palacin, Zorzano Antonio, Kondo, Richard, Palacín Prieto, Manuel, Ramon Gomis, Daniele Catalucci, Liesa Torre-Marín, Montserrat, Dillmann Wolfgang H., Marti Luc, Camps Camprubí, Marta, Zorzano, Antonio, Marta Camps, Pilar Ruiz-Lozano, Liesa, Marc, Kondo Richard, Gomis, Ramon, Marc Liesa, Theodore P Ciaraldi, Palacin Manuel   +49 more
core   +2 more sources

Availability and use of long-acting insulin analogues including their biosimilars across Africa; findings and implications [PDF]

, 2021
Background: Prevalence rates of diabetes mellitus are growing across Africa with an appreciable number likely to be on insulin to manage their condition. This has significant implications on future morbidity and mortality exacerbated by high complication
Kurdi, Amanj, Sefah, Israel, Njeri, Lisper Wangeci, Alutuli, Luke, Adwubi, Eunice Twumwaa, Abubakar, Abdullahi Rabiu, Phiri, Henry, Acolatse, Joseph, Kalemeera, Francis, Piloya-Were, Thereza, Ogunleye, Olayinka, Godman, Brian, Matowa, Patrick, Malande, Oliver Ombeva, Chikowe, Ibrahim, Chaibva, Blessmore Vimbai, Hango, Ester, Campbell, Stephen, Amu, Adefolarin A, Opanga, Sylvia, Sani, Ibrahim Haruna, Rwegerera, Godfrey Mutashambara, Incoom, Robert, Patrick, Okwen, Zaranyika, Trust, Allocati, Eleonora, Khuluza, Felix, Kimonge, David, Ibrahim, Kamilou, Haque, Mainul, Leong, Trudy, Lum Niba, Loveline, Kibuule, Dan, Kalungia, Aubrey Chichonyi, Oluka, Margaret   +34 more
core   +2 more sources

Development of AIDA v4.3b Diabetes Simulator: Technical Upgrade to Support Incorporation of Lispro, Aspart, and Glargine Insulin Analogues

Journal of Electrical and Computer Engineering, 2011
Introduction. AIDA is an interactive educational diabetes simulator available on the Internet without charge since 1996 (accessible at: http://www.2aida.org/).
Eldon D. Lehmann, Cristina Tarín, Jorge Bondia, Edgar Teufel, Tibor Deutsch   +4 more
doaj   +1 more source

Pasireotide in an insulin-requiring diabetic acromegalic patient without worsening of hyperglycemia

Endocrinology, Diabetes & Metabolism Case Reports, 2017
Long-acting pasireotide is an effective treatment option for acromegaly, but it is associated with hyperglycemia, which could impact its use in patients with diabetes.
Murray B Gordon, Kellie L Spiller
doaj   +1 more source

Massive Levemir (Long-Acting) Insulin Overdose: Case Report

Case Reports in Medicine, 2012
A 52-year-old insulin-dependant diabetic man presented to the Emergency Department 2 hours after a deliberate massive overdose of 2100 units of long-acting Levemir insulin and a large quantity of whisky.
Mamatha Oduru, Mahmood Ahmad
doaj   +1 more source

Is insulin topical gel better than simvastatin topical gel in full thickness wound?

Dermatology Reports, 2019
Due to issues of limited substances and expensive cost of wound treatment, topical insulin and simvastatin are being developed due to benefits including easy to find and applicable in every health center.
Timotius Hansen Arista, Agus Santoso Budi, Mirnasari Amirsyah, Nanda Febry Setyawati   +3 more
doaj   +1 more source

Comparative Drug Response Profiling in Neuroblastoma Cell Lines and Patient‐Derived Tumor Organoids

Pediatric Blood &Cancer, EarlyView.
ABSTRACT High‐risk neuroblastoma remains a leading cause of pediatric cancer mortality, and improved preclinical models are needed to guide therapeutic developments. We screened seven high‐risk neuroblastoma cell lines and three patient‐derived tumor organoids with 528 compounds alongside bone marrow controls, and compared them with external datasets ...
Krzysztof Wierbiłowicz, Se Whee Sammy Park, Aironas Los, Ernest Liu, Nona Struyf, Tom Erkers, Sören Lehmann, Jan J. Molenaar, Jakob Stenman, Olli Kallioniemi, Päivi Östling, Brinton Seashore‐Ludlow, Kasper Karlsson   +12 more
wiley   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source