Results 91 to 100 of about 286,304 (210)

Tissue‐Stimulator Platform for Electrically Stimulating Pancreatic β‐Cells for Long‐Term Functional Regulation

Advanced Functional Materials, EarlyView.
We present a tissue‐stimulator platform for seamless electrode integration with pancreatic tissue, applying uniform electrical stimulation through optimized design with biohybrid 3D printing. Advantageous effects of electrical stimulation on β‐cell function were observed, including enhanced calcium signaling, islet morphology, and maturation.
Jihwan Kim, Uijung Yong, Myungji Kim, Jaewook Kim, Yeonggwon Jo, In Kyong Shim, Song Cheol Kim, Jinah Jang   +7 more
wiley   +1 more source

Evaluating Serum Insulin-Like Growth Factor 1 and Insulin-Like Growth Factor Binding Protein 3 as Markers in Prostate Cancer Diagnosis

The International Journal of Biological Markers, 2016
Background Prostate-specific antigen (PSA) lacks specificity and sensitivity in discriminating prostate cancer (PCa) from benign prostatic hyperplasia (BPH) when the total PSA (tPSA) level is between 4 and 10 ng/mL.
Giulia Rainato, Aline S.C. Fabricio, Matelda Zancan, Lucia Peloso, Ruggero Dittadi, Mario Barichello, Andrea Fandella, Vincenzo Scattoni, Massimo Gion   +8 more
doaj   +1 more source

Expression of recombinant human insulin-like growth factor type 1 (rhiGF-1) in Escherichia Coli [PDF]

, 2015
Background: Human insulin-like growth factor type 1 (hIGF-1) is a protein consisting of 70 amino acids (MW=7.6 kDa) and mainly synthesized by liver.
Gharanjik, V., Iranpoor, H., Omidinia, E., Shahbazi, M., Vatankhah, V.   +4 more
core  

Paracrine Factor Local Gradient‐Generating System for Engineering Perfusable Vascularized Hepatocyte Tissues with Perfusion‐Induced Proliferation

Advanced Healthcare Materials, EarlyView.
A paracrine factor local gradient (PFLG)‐generating system enables microvessel penetration across 3D hepatocyte tissues. The resulting vascularized constructs recapitulate hepatic sinusoidal hepatocyte—endothelial contact architecture and enhance hepatic functions in vitro.
Yen‐Hsiang Huang, Tadahiro Yamashita, Ryo Sudo   +2 more
wiley   +1 more source

Interoceptive Information of Physical Vigor Through Circulating Insulin‐Like Growth Factor 1

FASEB BioAdvances
The brain relies on interoceptive feedback signals to regulate bodily functions. Female mice with low serum IGF‐1 levels (LID mice) exhibit reduced spontaneous running compared to control females, an effect not seen in males.
Jonathan A. Zegarra‐Valdivia, M. Zahid Khan, Jansen Fernandes, Kentaro Suda, M. Estrella Fernandez deSevilla, Sonia Díaz‐Pacheco, Ignacio Torres Aleman   +6 more
doaj   +1 more source

Causal associations between the insulin-like growth factor family and sarcopenia: a bidirectional Mendelian randomization study

Frontiers in Endocrinology
ObjectiveInsulin-like growth factor (IGF) is closely associated with sarcopenia, yet the causal relationship of this association remains unclear.
Jili Liu, Meng Chen, Xin Xia, Zhaolin Wang, Yanqin Wang, Ling Xi   +5 more
doaj   +1 more source

Astrocytic Insulin-Like Growth Factor-1 Protects Neurons Against Excitotoxicity

Frontiers in Cellular Neuroscience, 2019
BackgroundExogenous insulin like growth factor-1 (IGF-1) is known to be neuroprotective in animal models with brain insults, while it can also cause hyperexcitability in rodents.
Wei Chen, Bin He, Wusong Tong, Jinsong Zeng, Ping Zheng   +4 more
doaj   +1 more source

Dynamic Modulation of the Microenvironment Promotes Functional Maturation of Engineered Tissues

Advanced Healthcare Materials, EarlyView.
Engineered tissues lack the dynamic microenvironment of native tissues. A biocompatible, diffusible small molecule to dynamically modulate tissue microenvironments during maturation is used. Timing‐dependent modulation yields distinct outcomes, producing thicker, more native‐like blood vessels, stronger and more mature cardiac tissues, and optimized ...
Eric Silberman, Hadas Oved, Itay Gil, Amgad Marzook, Ester Sapir Baruch, Yahel Shechter, Assaf Shapira, Tal Dvir   +7 more
wiley   +1 more source

Seasonal Patterns in Growth Hormone, Insulin and Insulin-like Growth Factor-1 in Female Muskoxen

Rangifer, 1997
Over a year, mean serum growth hormone concentrations ranged from 0.5 to 3 ng/ml in tame muskoxen with the lowest values and fewest pulses between October and January. Serum insulin ranged from 0.25 to 0.92 ng/ml, with minima in summer. There were marked
Jan Z. Adamczewski, Susan C. Tedesco, Bernhard Laarveld, Peter F. Flood   +3 more
doaj   +1 more source

Vanadate and bone metabolism: effect on proliferation and mineralization of fish bone-derived cells [PDF]

, 2007
Vanadate is known for mimicking insulin action through activation of insulin and/or insulin like growth factor 1 (IGF 1) receptors. Vanadate insulin- like effect on bone-related metabolism has been previously investigated using mammalian in vitro cell ...
Aureliano, M., Cancela, Leonor, Laizé, Vincent, Tiago, Daniel   +3 more
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