Results 61 to 70 of about 113,501,887 (251)

Insulin-Like Growth Factor 1 Gene Polymorphism and Breast Cancer Risk Among Arab Omani Women: A Case-Control Study

, 2012
Breast cancer is the most common cancer worldwide with significant global burden. Insulin-like growth factor 1 (IGF1) is an important regulator of cellular growth, differentiation, and apoptosis and mitogenic and antiapoptotic activities.
Kawthar Al-Ajmi, Adil Al-Ajmi, Al Mandhari, Zahid, Al-Ajmi, Kawthar, Ganguly, Shyam S., Mansour S. Al-Moundhri, Shyam S. Ganguly, Al-Moundhri, Mansour S., Al-Ajmi, Adil, Zahid Al Mandhari   +9 more
core   +1 more source

Supplementary Figure from Linking Physical Activity to Breast Cancer Risk via Insulin/Insulin-Like Growth Factor Signaling System, Part 1: The Effect of Physical Activity on the Insulin/Insulin-Like Growth Factor Signaling System

, 2022
Supplementary Figure from Linking Physical Activity to Breast Cancer Risk via Insulin/Insulin-Like Growth Factor Signaling System, Part 1: The Effect of Physical Activity on the Insulin/Insulin-Like Growth Factor Signaling ...
Jamie E. Chong (15848962), Tom R. Gaunt (9983927), Ann E. Drummond (14855489), Tina L. Skinner (14855507), Kristy A. Brown (14855501), Dallas R. English (14855498), Christopher T.V. Swain (14855492), Roger L. Milne (14855495), Richard M. Martin (10538170), Sarah J. Lewis (14855513), Eline H. van Roekel (14855504), Brigid M. Lynch (14855516), Melissa M. Moore (14855510)   +12 more
core   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Evaluation of Insulin-like Growth Factor-1 and Insulin-like Growth Factor Binding Protein-3 Expression Levels in Patients with Chronic Lymphocytic Leukemia

Turkish Journal of Hematology, 2016
Objective: Chronic lymphocytic leukemia (CLL) is a disease of nonproliferating and mature-appearing B lymphocytes. Insulin-like growth factor-1 (IGF-1) is a small peptide hormone and has mitogenic and antiapoptotic effects, and insulin-like growth ...
Mesut Ayer, Abdullah Sakin, Selim Ay, Aylin Ayer, Elif Gökçen Sazak, Melih Aktan   +5 more
doaj   +1 more source

Phosphorylated insulin-like growth factor-1 receptor (pIGF1R) is a poor prognostic factor in brain metastases from lung adenocarcinomas

, 2014
A greater understanding of brain metastases is imperative for developing novel therapeutic strategies. Our previous study showed that insulin-like growth factor (IGF) signaling pathway was activated in brain-tropic cancer cells.
Wu, Pei-Fang;Huang, Wen-Chang;Yang, James Chih-Hsin;Lu, Yen-Shen;Shih, Jin-Yuan;Wu, Shang-Gin;Lin, Ching-Hung;Cheng, Ann-Lii, 楊志新 ;盧彥伸 ;鄭安理 ;吳尚俊 ;施金元 ;林璟宏   +1 more
core   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Role of Insulin-like Growth Factor Binding Protein 3 as a Diagnostic Marker of Growth Hormone in Patients with Acromegaly

Mìžnarodnij Endokrinologìčnij Žurnal, 2013
The paper studied the levels IGFBP-3 in patients with acromegaly, received different therapies. The findings showed that patients with acromegaly after surgical removal of a pituitary tumor, as well as after radiation therapy, the most sensitive ...
A.O. Kholikova
doaj   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source