Results 61 to 70 of about 360,848 (218)

Making the Case for Organ‐on‐Chip Platforms in Long‐Acting Therapeutics Development

Advanced Healthcare Materials, EarlyView.
LATs release drug from a tissue‐resident depot over weeks to months, improving adherence, but their development is hampered by preclinical models that cannot reproduce the coupled tissue processes, sustained release, local microenvironment change, interstitial transport, immune and foreign‐body responses, and clearance that govern depot performance in ...
Charlie Gowans, Abdulwahhab Khedr, Panagiotis G. Georgiou, Nehir Arik, Ozlem Sen, Steve P. Rannard, Tom O. McDonald, Christos Tapeinos   +7 more
wiley   +1 more source

Causal associations between the insulin-like growth factor family and sarcopenia: a bidirectional Mendelian randomization study

Frontiers in Endocrinology
ObjectiveInsulin-like growth factor (IGF) is closely associated with sarcopenia, yet the causal relationship of this association remains unclear.
Jili Liu, Meng Chen, Xin Xia, Zhaolin Wang, Yanqin Wang, Ling Xi   +5 more
doaj   +1 more source

Evaluating Serum Insulin-Like Growth Factor 1 and Insulin-Like Growth Factor Binding Protein 3 as Markers in Prostate Cancer Diagnosis

The International Journal of Biological Markers, 2016
Background Prostate-specific antigen (PSA) lacks specificity and sensitivity in discriminating prostate cancer (PCa) from benign prostatic hyperplasia (BPH) when the total PSA (tPSA) level is between 4 and 10 ng/mL.
Giulia Rainato, Aline S.C. Fabricio, Matelda Zancan, Lucia Peloso, Ruggero Dittadi, Mario Barichello, Andrea Fandella, Vincenzo Scattoni, Massimo Gion   +8 more
doaj   +1 more source

Targeting CD300a Signaling With a Phosphatidylserine‐Presenting Hydrogel Rescues Macrophage Dysfunction and Accelerates Diabetic Wound Healing

Advanced Healthcare Materials, EarlyView.
Schematic illustration of the proposed mechanism: PEG/RGD‐PSLs mimic apoptotic cells to engage PS receptors (notably CD300a), transducing an inhibitory signal that suppresses the MyD88/NF‐κB pathway, leading to global anti‐inflammatory and pro‐reparative effects.
Lele Wu, Xuetong Hao, Yang Zou, Xinglin Chen, Junyan Kong, Chunning Gu, Wenjie Ma, Zhongjun Yang, Huifen Liu, Mengmeng Liu, Xin Tong   +10 more
wiley   +1 more source

Astrocytic Insulin-Like Growth Factor-1 Protects Neurons Against Excitotoxicity

Frontiers in Cellular Neuroscience, 2019
BackgroundExogenous insulin like growth factor-1 (IGF-1) is known to be neuroprotective in animal models with brain insults, while it can also cause hyperexcitability in rodents.
Wei Chen, Bin He, Wusong Tong, Jinsong Zeng, Ping Zheng   +4 more
doaj   +1 more source

PLL‐g‐HPA Hydrogel Microneedles Loaded With Rhoifolin Target Macrophages to Alleviate Fibroblast Senescence for Diabetic Wound Healing

Advanced Healthcare Materials, EarlyView.
Diabetic wound healing is hindered by a pathological crosstalk wherein elevated IL‐11 induces M1 macrophage polarization, leading to IL‐1β/IL‐6 release and subsequent fibroblast senescence via RAS/p38MAPK/p53/E2F1 signaling. Here, we develop a Gel@M‐Rho microneedle patch that delivers rhoifolin‐loaded, macrophage membrane‐coated nanoparticles to target
Jiewen Liao, Lin Gan, Li Lu, Lizhi Ouyang, Yuan Xiong, Fawwaz Al‐Smadi, Guandong Dai, Mohammad‐Ali Shahbazi, Bobin Mi, Mengfei Liu, Guohui Liu   +10 more
wiley   +1 more source

Insulin-like growth factor-1 (IGF-1) empowering tendon regenerative therapies

Frontiers in Bioengineering and Biotechnology
Tendon injury is one of the most common musculoskeletal disorders that severely affect patients’ daily lives. Unfortunately, naturally healed tendons exhibit poor quality, as they have very limited regenerative ability.
Mingming Wang, Jiayuan Zhang, Hanyue Li, Yini Li, Zhigang Li   +4 more
doaj   +1 more source

Seasonal Patterns in Growth Hormone, Insulin and Insulin-like Growth Factor-1 in Female Muskoxen

Rangifer, 1997
Over a year, mean serum growth hormone concentrations ranged from 0.5 to 3 ng/ml in tame muskoxen with the lowest values and fewest pulses between October and January. Serum insulin ranged from 0.25 to 0.92 ng/ml, with minima in summer. There were marked
Jan Z. Adamczewski, Susan C. Tedesco, Bernhard Laarveld, Peter F. Flood   +3 more
doaj   +1 more source

Chemical Strategies for Multistimuli Responsive Dynamic Covalent Materials in Regenerative Medicine

Advanced Healthcare Materials, EarlyView.
Multistimuli responsive dynamic covalent materials integrate reversible chemistry with the complex chemical, mechanical, and biochemical cues of regenerative environments. This review highlights chemical strategies based on orthogonal dynamic bonds, multicomponent networks, and hierarchical architectures to regulate mechanics, degradation, and ...
Saurabh Joshi, Matthew B. Baker, Dominik Schauenburg   +2 more
wiley   +1 more source

Self‐Healing Hydrogel‐Enabled Modular Assembly of Bilayered Skin Construct for Hair Follicle Regeneration

Advanced Healthcare Materials, EarlyView.
Self‐healing assembly of two cell‐laden hydrogel layers creates a biomimetic skin construct that restores both dermal and epidermal functions, resulting in accelerated wound healing and enhanced hair follicle regeneration in a full‐thickness skin wound model. ABSTRACT Alopecia remains a pervasive clinical challenge, largely owing to the limited ability
JaeWook Park, Su Yong Kim, MinSu Jeong, Beom Joon Kim, Shin Hyuk Kang, Won‐Gun Koh   +5 more
wiley   +1 more source