Results 111 to 120 of about 257,551 (158)

Targeting insulin-like growth factor 1 receptor in sarcomas

Current Opinion in Oncology, 2008
The present review examines the rationale for targeting insulin-like growth factor-I receptor in sarcoma therapy and highlights some key issues that need to be addressed as clinical trials targeting insulin-like growth factor-I receptor proceed.Preclinical evidence supports proof of principle for targeting insulin-like growth factor-I receptor ...
Katia, Scotlandi, Piero, Picci
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Expression of insulin-like growth factor-1 and insulin-like growth factor-1 receptors in EL4 lymphoma cells overexpressing growth hormone

Cellular Immunology, 2005
Almost all of the previous studies with growth hormone (GH) have been done with exogenously supplied GH and, therefore, involve actions of the hormone through its receptor. However, the actions of endogenous or lymphocyte GH are still unclear. In a previous study, we showed that overexpression of GH (GHo) in a lymphoid cell line resulted in protection ...
Douglas A, Weigent, Robyn E, Arnold
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Seasonal expressions of growth hormone receptor, insulin-like growth factor 1 and insulin-like growth factor 1 receptor in the scented glands of the muskrats (Ondatra zibethicus)

General and Comparative Endocrinology, 2019
The growth hormone (GH)/insulin-like growth factor-1 (IGF-1) system plays an important role in regulating the cellular growth and organ development. The present study investigated the seasonal expressions of growth hormone receptor (GHR), IGF-1 and insulin-like growth factor 1 receptor (IGF-1R) in the scented glands of the muskrats.
Wenqian, Xie, Zeqi, Tang, Yuanyuan, Guo, Chunjiao, Zhang, Haolin, Zhang, Yingying, Han, Zhengrong, Yuan, Qiang, Weng   +7 more
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The complex biology of the receptor for the insulin-like growth factor-1

Drug News & Perspectives, 2003
The receptor for the insulin-like growth factor-1 (IGF-1R) controls a wide variety of cellular functions. IGF-1R is a tyrosine kinase receptor that is activated by the binding of a ligand to the extracellular domain. There are three ligands for IGF-1R: IGF-I, IGF-II and insulin at supraphysiological concentrations.
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Association of Insulin-Like Growth Factor-1 Receptor Polymorphism in Dementia

Dementia and Geriatric Cognitive Disorders, 2006
There is an increasing interest in how oxidative stress can cause cells to go into apoptosis in both normal ageing and in neurodegenerative disorders. Previous research has implicated insulin-like growth factor-1 (IGF-1) as being involved in the pathogenesis in Alzheimer’s disease (AD) by protecting the neurons through reducing neuronal susceptibility ...
J, Garcia, A, Ahmadi, A, Wonnacott, W, Sutcliffe, K, Nagga, P, Soderkvist, J, Marcusson   +6 more
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Growth and the Insulin-Like Growth Factor-1 Receptor (IGF1R)

2011
The insulin-like growth factor-1 receptor (IGF-1R) is a membrane-bound tyrosine kinase receptor capable of auto-phosphorylation following ligand binding. While IGF-1 is the major ligand for this receptor, both IGF-2 and insulin can bind to the IGF-1R.
Maria Belen Roldan Martin, Selma Feldman Witchel   +1 more
openaire   +1 more source

Targeted Therapy of the Insulin-Like Growth Factor-1 Receptor in Cancer

Combinatorial Chemistry & High Throughput Screening, 2008
Recently, significant progress has been made towards understanding the pathogenesis of cancer from the molecular standpoint. To this end, a growing number of approaches are being exploited for the identification and validation of new therapeutic targets suitable for potent and specific intervention.
Keren, Paz, Yaron R, Hadari
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Insulin‐like growth factor‐1 receptor acts as a growth regulator in synovial sarcoma

The Journal of Pathology, 2008
AbstractSynovial sarcomas account for 5–10% of all soft tissue sarcomas and the majority of synovial sarcomas display characteristic t(X;18) translocations that result in enhanced transcription of the insulin‐like growth factor‐2 (IGF‐2) gene. IGF‐2 is an essential fetal mitogen involved in the pathogenesis of different tumours, leading to cellular ...
Friedrichs, N., Küchler, J., Endl, E., Koch, A., Czerwitzki, J., Wurst, P., Metzger, D., Schulte, Johannes, Holst, M. I., Heukamp, L. C., Larsson, O., Tanaka, S., Kawai, A., Wardelmann, E., Buettner, R., Pietsch, T., Hartmann, W.   +16 more
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Insulin Like Growth Factor 1 Receptor Signal Transduction to the Nucleus

1994
The mechanism by which IGF-1Rs regulate the growth and maintenance of cells in normal and disease states provides an important setting for studies addressing signal transduction events at the nuclear level. With the identification of c-Jun/AP-1 as a nuclear target of IGF-1 action we are provided with a model system for pursuing the molecular mechanisms
S A, Rosenzweig, B S, Oemar, N M, Law, U T, Shankavaram, B S, Miller   +4 more
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