Insulin-like growth factor 1 receptor mediates photoreceptor neuroprotection [PDF]
Cell Death and Disease, 2022 Insulin-like growth factor I (IGF-1) is a neurotrophic factor and is the ligand for insulin-like growth factor 1 receptor (IGF-1R). Reduced expression of IGF-1 has been reported to cause deafness, mental retardation, postnatal growth failure, and ...
Ammaji Rajala +6 more
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Insulin-like growth factor-1/insulin-like growth factor-1 receptor signalling in macrophages facilitates recovery from acute lung injury [PDF]
Annals of MedicineBackground No effective treatment strategy for acute respiratory distress syndrome (ARDS) has been established. Conflicting reports on the effects of insulin-like growth factor (IGF)-1 stimulation and the inhibition of IGF-1 receptor (IGF-1R) signalling ...
Miyuki Niisato +5 more
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Contrasting consequences of podocyte insulin-like growth factor 1 receptor inhibition [PDF]
iScienceSummary: Insulin signaling to the glomerular podocyte via the insulin receptor (IR) is critical for kidney function. In this study we show that near-complete knockout of the closely related insulin-like growth factor 1 receptor (IGF1R) in podocytes is ...
Jennifer A. Hurcombe +12 more
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Membrane-anchored intracellular insulin receptor or insulin-like growth factor-1 receptor elicits ligand-independent downstream signaling [PDF]
Biochemistry and Biophysics ReportsNeurodegenerative diseases including glaucoma affect insulin signaling, and insulin treatment has been shown to reverse the neurodegenerative loss of dendritic complexity in retinal ganglion cells.
Akiko Sotozono +7 more
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Insulin-like growth factor 1 receptor regulates breast cancer cell adhesion through beta-1 integrin [PDF]
Frontiers in EndocrinologyIntroductionThe insulin-like growth factor (IGF-1/IGF1R) pathway has been implicated in breast cancer aggressiveness; however, inhibition of this pathway has not been successful in clinical trials, indicating a lack of understanding about its role in ...
Christopher A. Galifi +11 more
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Murine neonatal cardiac regeneration depends on Insulin-like growth factor 1 receptor signaling [PDF]
Scientific ReportsUnlike adult mammals, the hearts of neonatal mice possess the ability to completely regenerate from myocardial infarction (MI). This observation has sparked vast interest in deciphering the potentially lifesaving and morbidity-reducing mechanisms ...
Thomas Schuetz +14 more
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Genetic screening of the insulin-like growth factor 1 receptor gene in children born small for gestational age: the continuing importance of insulin-like growth factor 1 signaling [PDF]
Endocrine JournalChildren born small for gestational age (SGA) who fail to experience catch-up growth often remain short-statured with heterogeneous etiologies, including genetic factors.
Jun-Hong Park +7 more
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Zhongliu Fangzhi Yanjiu, 2022 Objective To investigate the effect of IGF1R β subunit mutants sb-IGF1R and ma-IGF1R on the biological behavior of osteosarcoma 143B cells. Methods We designed and constructed sb-IGF1R and ma-IGF1R fragments.
WEN Zhongchi1 +6 more
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Microgravity, Bone Homeostasis, and Insulin-Like Growth Factor-1
Applied Sciences, 2020 Astronauts at are risk of losing 1.0–1.5% of their bone mass for every month they spend in space despite their adherence to high impact exercise training programs and diets high in nutrients, potassium, calcium, and vitamin D, all designed to preserve ...
John Kelly Smith
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Targeting insulin-like growth factor 1 receptor inhibits pancreatic cancer growth and metastasis. [PDF]
PLoS ONE, 2014 Pancreatic cancer is one of the most lethal cancers. Increasing incidence and mortality indicates that there is still much lacking in detection and management of the disease.
Ramadevi Subramani +5 more
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