Results 1 to 10 of about 40,050,075 (282)

Insulin-like growth factor 1 receptor mediates photoreceptor neuroprotection [PDF]

Cell Death and Disease, 2022
Insulin-like growth factor I (IGF-1) is a neurotrophic factor and is the ligand for insulin-like growth factor 1 receptor (IGF-1R). Reduced expression of IGF-1 has been reported to cause deafness, mental retardation, postnatal growth failure, and ...
Ammaji Rajala, Kenneth Teel, Mohd A. Bhat, Albert Batushansky, Timothy M. Griffin, Lindsey Purcell, Raju V. S. Rajala   +6 more
doaj   +4 more sources

Glycan Modulation of Insulin-like Growth Factor-1 Receptor. [PDF]

Angew Chem Int Ed Engl, 2022
AbstractThe insulin‐like growth factor‐1 receptor (IGF‐1R) is a receptor tyrosine kinase (RTK) that plays critical roles in cancer. Microarray, computational, thermodynamic, and cellular imaging studies reveal that activation of IGF‐1R by its cognate ligand IGF1 is inhibited by shorter, soluble heparan sulfate (HS) sequences (e.g., HS06), whereas ...
Boothello RS, Sankaranarayanan NV, Sistla JC, Nagarajan B, Sharon C, Chittum JE, Niyaz RY, Roy S, Nandi A, O'Hara CP, Gangji RN, Afosah DK, Ongolu R, Patel BB, Desai UR.   +14 more
europepmc   +3 more sources

How insulin-like growth factor I binds to a hybrid insulin receptor type 1 insulin-like growth factor receptor

Structure, 2022
Monomers of the insulin receptor and type 1 insulin-like growth factor receptor (IGF-1R) can combine stochastically to form heterodimeric hybrid receptors. These hybrid receptors display ligand binding and signaling properties that differ from those of the homodimeric receptors.
Nicholas Stephen Kirk, Tristan Croll, Michael C Lawrence   +2 more
exaly   +4 more sources

Insulin-like growth factor-1/insulin-like growth factor-1 receptor signalling in macrophages facilitates recovery from acute lung injury [PDF]

Annals of Medicine
Background No effective treatment strategy for acute respiratory distress syndrome (ARDS) has been established. Conflicting reports on the effects of insulin-like growth factor (IGF)-1 stimulation and the inhibition of IGF-1 receptor (IGF-1R) signalling ...
Miyuki Niisato, Masahiro Yamashita, Yasushi Kawasaki, Hiroshi Furukawa, Takashi Sato, Ichiro Kawada   +5 more
doaj   +2 more sources

Targeting the insulin-like growth factor-1 receptor in human cancer [PDF]

Frontiers in Pharmacology, 2013
The insulin-like growth factor (IGF) signaling system plays a crucial role in human cancer and the IGF-1 receptor (IGF-1R) is an attractive drug target against which a variety of novel anti-tumor agents are being developed.
Alexandre eArcaro
doaj   +4 more sources

Contrasting consequences of podocyte insulin-like growth factor 1 receptor inhibition [PDF]

iScience
Summary: Insulin signaling to the glomerular podocyte via the insulin receptor (IR) is critical for kidney function. In this study we show that near-complete knockout of the closely related insulin-like growth factor 1 receptor (IGF1R) in podocytes is ...
Jennifer A. Hurcombe, Fern Barrington, Micol Marchetti, Virginie M.S. Betin, Emily E. Bowen, Abigail C. Lay, Lan Ni, Lusyan Dayalan, Robert J.P. Pope, Paul T. Brinkkoetter, Martin Holzenberger, Gavin I. Welsh, Richard J.M. Coward   +12 more
doaj   +2 more sources

Membrane-anchored intracellular insulin receptor or insulin-like growth factor-1 receptor elicits ligand-independent downstream signaling [PDF]

Biochemistry and Biophysics Reports
Neurodegenerative diseases including glaucoma affect insulin signaling, and insulin treatment has been shown to reverse the neurodegenerative loss of dendritic complexity in retinal ganglion cells.
Akiko Sotozono, Kazuhiko Namekata, Xiaoli Guo, Youichi Shinozaki, Chikako Harada, Takahiko Noro, Tadashi Nakano, Takayuki Harada   +7 more
doaj   +2 more sources

Insulin-like growth factor 1 receptor regulates breast cancer cell adhesion through beta-1 integrin [PDF]

Frontiers in Endocrinology
IntroductionThe insulin-like growth factor (IGF-1/IGF1R) pathway has been implicated in breast cancer aggressiveness; however, inhibition of this pathway has not been successful in clinical trials, indicating a lack of understanding about its role in ...
Christopher A. Galifi, Elvan Dogan, Luis Fernandez Almansa, Krystopher Maingrette, Simran S. Shah, Joseph J. Bulatowicz, Karen Ebenezer, Utz Herbig, Utz Herbig, Amir K. Miri, Amir K. Miri, Teresa L. Wood   +11 more
doaj   +2 more sources

Insulin-like growth factor 1 receptor is a prognostic factor in classical Hodgkin lymphoma. [PDF]

PLoS ONE, 2014
The interaction between the tumor cells in classical Hodgkin lymphoma (cHL) and the microenvironment includes aberrant activity of receptor tyrosine kinases.
Zheng Liang, Arjan Diepstra, Chuanhui Xu, Gustaaf van Imhoff, Wouter Plattel, Anke Van Den Berg, Lydia Visser   +6 more
doaj   +4 more sources

Murine neonatal cardiac regeneration depends on Insulin-like growth factor 1 receptor signaling [PDF]

Scientific Reports
Unlike adult mammals, the hearts of neonatal mice possess the ability to completely regenerate from myocardial infarction (MI). This observation has sparked vast interest in deciphering the potentially lifesaving and morbidity-reducing mechanisms ...
Thomas Schuetz, Theresa Dolejsi, Eva Beck, Fabio Fugger, Alexander Bild, Marie-Theres Duin, Jasmina Gavranovic-Novakovic, Erika Hilbold, Thomas Hoffmann, Johannes Zuber, Axel Bauer, Frank Ruschitzka, Christian Bär, Josef Martin Penninger, Bernhard Johannes Haubner   +14 more
doaj   +2 more sources