Results 41 to 50 of about 113,446,571 (293)

The type 1 insulin-like growth factor receptor and resistance to DACH1 [PDF]

Cell Cycle, 2011
The mammalian homolog of the Drosophila dachshund gene (DACH1) has been reported as a tumor suppressor in human breast and prostate cancers. It downregulates the epidermal growth factor receptor (EGFR) and cyclin D1. The signaling pathway of the type 1 insulin-like growth factor receptor (IGF-IR) is known to be responsible for the development of ...
Tiziana, DeAngelis, Kongming, Wu, Richard, Pestell, Renato, Baserga   +3 more
openaire   +2 more sources

Activation of epidermal growth factor receptor/insulin-like growth factor 1 receptor-β-Catenin-CD44 pathway in periampullary cancer

Journal of Radiation and Cancer Research, 2020
Background: Periampullary cancer (PC) is a global medical burden. Less than 5% of patients experience an overall survival of 5 years or more. The study aims to analyze the importance of epidermal growth factor receptor (EGFR)/insulin-like growth factor 1
Biswabandhu Bankura, Suvendu Maji, Balarko Chakraborty, Neyaz Alam, Chinmay Kumar Panda   +4 more
doaj   +1 more source

Role of insulin-like growth factor 1 receptor signalling in cancer [PDF]

British Journal of Cancer, 2005
The insulin-like growth factor (IGF-1) signalling is highly implicated in cancer. In this signalling the IGF-1 receptor (IGF-1R) is unquestionable, the predominating single factor. IGF-1R is crucial for tumour transformation and survival of malignant cell, but is only partially involved in normal cell growth.
Larsson, O, Girnita, A, Girnita, L
openaire   +3 more sources

IGF2R (insulin-like growth factor 2 receptor) [PDF]

, 2004
Review on IGF2R (insulin-like growth factor 2 receptor), with data on DNA, on the protein encoded, and where the gene is ...
Killian, JK
core   +1 more source

The Role of Insulin and Insulin-like Growth Factors in the Increased Risk of Cancer in Diabetes

Rambam Maimonides Medical Journal, 2011
Patients with type 2 diabetes (T2D) are at increased risk of developing cancer. This evidence arises from numerous epidemiologic studies that relate a positive association between T2D and cancer. In-vitro and several in-vivo experiments have attempted to
Derek LeRoith, Eyal J. Scheinman, Keren Bitton-Worms   +2 more
doaj   +1 more source

Insulin-Like Growth Factor-1 Receptor Expression in Thymic Malignancies [PDF]

Journal of Thoracic Oncology, 2010
Thymic epithelial tumors are rare mediastinal malignancies that can be invasive and difficult to treat. Insulin-like growth factor-1 receptor (IGF-1R) is a transmembrane receptor implicated in the regulation of cell metabolism, growth, and survival. As higher levels of IGF-1R protein expression may be associated with relative sensitivity to anti-IGF-1R
Girard, Nicolas, Teruya-Feldstein, Julie, Payabyab, Eden C., Riely, Gregory J., Rusch, Valerie W., Kris, Mark G., Zakowski, Maureen F.   +6 more
openaire   +2 more sources

Pleiotropic Genes Affecting Carcass Traits in Bos indicus (Nellore) Cattle Are Modulators of Growth. [PDF]

PLoS ONE, 2016
Two complementary methods, namely Multi-Trait Meta-Analysis and Versatile Gene-Based Test for Genome-wide Association Studies (VEGAS), were used to identify putative pleiotropic genes affecting carcass traits in Bos indicus (Nellore) cattle.
Anirene G T Pereira, Yuri T Utsunomiya, Marco Milanesi, Rafaela B P Torrecilha, Adriana S Carmo, Haroldo H R Neves, Roberto Carvalheiro, Paolo Ajmone-Marsan, Tad S Sonstegard, Johann Sölkner, Carmen J Contreras-Castillo, José F Garcia   +11 more
doaj   +1 more source

Insulin-Like Growth Factor-1 Receptor Targeted Fluorescent Imaging for Gallbladder Cancer in Orthotopic Mouse Models

Gut and Liver, 2022
Background/Aims: Gallbladder cancer is fatal, but fluorescent imaging technology can facilitate timely diagnosis and improve patient outcomes. Fluorophore-conjugated insulin-like growth factor-1 receptor (IGF-1R) targeted antibodies were used to ...
Jung Ha Choi, Jeong Youp Park
doaj   +1 more source

How ligand binds to the type 1 insulin-like growth factor receptor

Nature Communications, 2018
The human type 1 insulin-like growth factor receptor (IGF-1R) is important for normal human growth and development. Here, the authors present the crystal structures of the IGF-1R ectodomain both in its apo form and in complex with its ligand insulin-like
Yibin Xu, Geoffrey K.-W. Kong, John G. Menting, Mai B. Margetts, Carlie A. Delaine, Lauren M. Jenkin, Vladislav V. Kiselyov, Pierre De Meyts, Briony E. Forbes, Michael C. Lawrence   +9 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source