Genetic screening of the insulin-like growth factor 1 receptor gene in children born small for gestational age: the continuing importance of insulin-like growth factor 1 signaling [PDF]
Endocrine JournalChildren born small for gestational age (SGA) who fail to experience catch-up growth often remain short-statured with heterogeneous etiologies, including genetic factors.
Jun-Hong Park +7 more
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Associations of insulin and insulin-like growth factors with physical performance in old age in the boyd orr and caerphilly studies. [PDF]
, 2012 OBJECTIVE: Insulin and the insulin-like growth factor (IGF) system regulate growth and are involved in determining muscle mass, strength and body composition.
David Gunnell +39 more
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Regulation of human fibroblast insulin-like growth factor (IGF)-binding proteins by IGF-1 and cytokines, mechanisms of action and effects upon IGF bioactivity [PDF]
, 1995 PhDThe insulin-like growth factors, IGF-I and IGF-II, are ubiquitous polypeptide molecules that have mitogenic and metabolic actions in a wide variety of cell types, and consequently play a major role in mammalian growth and development.
Yateman, Martin Edward
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The Type 1 Insulin-Like Growth Factor Receptor Pathway [PDF]
Clinical Cancer Research, 2008 Abstract Research conducted over the past two decades has shown the importance of the type 1 insulin-like growth factor receptor (IGF1R) in tumorigenesis, metastasis, and resistance to existing forms of cancer therapy. The IGF1R itself has only recently been accepted as a credible treatment target, however, perhaps reflecting the ...
Chitnis, M +4 more
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Molecular evolution and functional characterization of Drosophila insulin-like peptides [PDF]
, 2010 Multicellular animals match costly activities, such as growth and reproduction, to the environment through nutrient-sensing pathways. The insulin/IGF signaling (IIS) pathway plays key roles in growth, metabolism, stress resistance, reproduction, and ...
Andrews, T Daniel +4 more
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Zhongliu Fangzhi Yanjiu, 2022 Objective To investigate the effect of IGF1R β subunit mutants sb-IGF1R and ma-IGF1R on the biological behavior of osteosarcoma 143B cells. Methods We designed and constructed sb-IGF1R and ma-IGF1R fragments.
WEN Zhongchi1 +6 more
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Microgravity, Bone Homeostasis, and Insulin-Like Growth Factor-1
Applied Sciences, 2020 Astronauts at are risk of losing 1.0–1.5% of their bone mass for every month they spend in space despite their adherence to high impact exercise training programs and diets high in nutrients, potassium, calcium, and vitamin D, all designed to preserve ...
John Kelly Smith
doaj +1 more source
Targeting insulin-like growth factor 1 receptor inhibits pancreatic cancer growth and metastasis. [PDF]
PLoS ONE, 2014 Pancreatic cancer is one of the most lethal cancers. Increasing incidence and mortality indicates that there is still much lacking in detection and management of the disease.
Ramadevi Subramani +5 more
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The contradictions of the insulin-like growth factor 1 receptor [PDF]
Oncogene, 2000 In recent years, the type 1 insulin-like growth factor receptor (IGF-IR) has emerged as a receptor that plays a very important role in the growth of cells, both in vivo and in vitro. The ability of the IGF-IR to induce mitogenesis and to promote survival of cells against a variety of apoptotic agents is well documented.
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IGF1R (insulin-like growth factor 1 receptor) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on IGF1R (insulin-like growth factor 1 receptor), with data on DNA, on the protein encoded, and where the gene is implicated.
Bentov, Y, Werner, H
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