Results 121 to 130 of about 257,551 (158)
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The insulin-like growth factor 1 receptor in cancer
European Journal of Cancer, 2007The importance of insulin-like growth factor 1 receptor (IGF-1R) signalling in malignant behaviour of tumour cells is well established. Currently, development of drugs targeting the IGF-1R as anticancer treatment is emerging. Several IGF-1R targeting strategies are being investigated in phases I and II clinical trials.
Hartog, Hermien +3 more
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Insulin-Like Growth Factor 1 Receptor Promotes the Growth and Chemoresistance of Pancreatic Cancer
Digestive Diseases and Sciences, 2013Insulin-like growth factor 1 receptor (IGF1R) plays important roles in the progression of pancreatic cancer. However, the underlying mechanism remains unclear.The purpose of this study was to investigate the effects of IGF1R knockdown on the proliferation, apoptosis and chemosensitivity of pancreatic cancer cells, and explore the possible mechanisms ...
Xiaodong, Tian +5 more
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Cyclolignans as Inhibitors of the Insulin-Like Growth Factor-1 Receptor and Malignant Cell Growth
Cancer Research, 2004AbstractThe insulin-like growth factor-1 receptor (IGF-1R) plays a pivotal role in transformation, growth, and survival of malignant cells, and has emerged as a general and promising target for cancer treatment. However, no fully selective IGF-1R inhibitors have thus far been found.
Ada, Girnita +5 more
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International Journal of Molecular Medicine, 1998
Growth factors are frequently involved in the regulation of mitosis and differentiation of several cell types and insulin-like growth factor-1 (IGF-1) is actively involved in the thyroid stimulating hormone-mediated proliferation of thyrocytes. In view of the pivotal role of IGF-1 in thyrocyte proliferation and of the still unsettled role of this ...
Maiorano E +5 more
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Growth factors are frequently involved in the regulation of mitosis and differentiation of several cell types and insulin-like growth factor-1 (IGF-1) is actively involved in the thyroid stimulating hormone-mediated proliferation of thyrocytes. In view of the pivotal role of IGF-1 in thyrocyte proliferation and of the still unsettled role of this ...
Maiorano E +5 more
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Cancer Research, 2010
Abstract Introduction: The insulin-like growth factor pathway, which is involved in cell proliferation, differentiation and protection against apoptosis, has been implicated in esophageal cancer progression. This study examined the role of insulin-like growth factor-1 (IGF-1) and insulin-like growth factor-1 receptor (IGF-1R) as a ...
Suzanne L. Doyle +5 more
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Abstract Introduction: The insulin-like growth factor pathway, which is involved in cell proliferation, differentiation and protection against apoptosis, has been implicated in esophageal cancer progression. This study examined the role of insulin-like growth factor-1 (IGF-1) and insulin-like growth factor-1 receptor (IGF-1R) as a ...
Suzanne L. Doyle +5 more
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HASF (C3orf58) is a novel ligand of the insulin-like growth factor 1 receptor
Biochemical Journal, 2017We have recently shown that hypoxia and Akt-induced stem cell factor (HASF) protects the heart from ischemia-induced damage and promotes cardiomyocyte proliferation. While we have identified certain signaling pathways responsible for these protective effects, the receptor mediating these effects was unknown.
Akshay, Bareja +4 more
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Neuroendocrinology, 2002
Interactions between thymocytes and thymic epithelial cell (TEC) can be modulated by growth hormone via insulin-like growth factor-1 (IGF-1). In this study, we showed IGF-1 and IGF-1 receptor mRNA expression by human and murine TEC and thymocytes. Functionally, IGF-1 stimulates extracellular matrix production by human TEC.
Valéria, de Mello Coelho +5 more
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Interactions between thymocytes and thymic epithelial cell (TEC) can be modulated by growth hormone via insulin-like growth factor-1 (IGF-1). In this study, we showed IGF-1 and IGF-1 receptor mRNA expression by human and murine TEC and thymocytes. Functionally, IGF-1 stimulates extracellular matrix production by human TEC.
Valéria, de Mello Coelho +5 more
openaire +2 more sources
Expression of insulin-like growth factor-1 receptor in human colorectal cancer
Human Pathology, 1999The activation of the insulinlike growth factor 1/IGF-1 receptor system (IGF1/IGF1-R) has recently emerged as critical event in transformation and tumorigenicity of several murine and human tumors. Expression of IGF1 and of IGF1-R has been demonstrated in normal and neoplastic intestinal cell lines of rats and humans.
A, Hakam +7 more
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