Results 211 to 220 of about 200,349 (246)

Role of Growth-Hormone and Insulin-Like Growth-Factor-Binding Proteins

Hormone Research, 2008
Some peptide hormones are associated with specific, high-affinity plasma proteins. The major binding protein (BP) for growth hormone (GH) in humans is a circulating fragment of the GH membrane receptor, consisting of the hydrophilic, extracellular portion of that transmembrane glycoportein.
openaire   +2 more sources

Heterogeneity of insulin-like growth factor binding proteins in swine

Molecular and Cellular Endocrinology, 1989
Proteins in porcine amniotic fluid and sera (both fetal and adult) were separated electrophoretically in sodium dodecyl sulfate-containing polyacrylamide gels and transferred to nitrocellulose sheets. Western blots were analysed for proteins that would bind (a) radioiodinated insulin-like growth factor-I (IGF-I) and (b) antibodies to a rat insulin-like
G E, Veomett, L L, Munger, G L, Smith, J E, Schollmeyer   +3 more
openaire   +2 more sources

Characterization of urinary insulin-like growth factor binding proteins

The Journal of Clinical Endocrinology & Metabolism, 1992
The insulin-like growth factors (IGFs) are important mitogens that are present in many body fluids, where they are commonly bound with high affinity to IGF binding proteins (IGFBPs). We investigated human urine for the presence of IGFBPs. Western ligand blots of concentrated, dialyzed normal urine disclosed the presence of two major bands with IGF ...
Y, Hasegawa, P, Cohen, P, Yorgin, R G, Rosenfeld   +3 more
openaire   +2 more sources

Regulatory Actions of Insulin-like Growth Factor-binding Proteins

Trends in Endocrinology & Metabolism, 1998
The six insulin-like growth factor-binding proteins (IGFBPs) are important regulators of insulin-like growth factor (IGF) action. Circulating high molecular weight complexes that contain IGF and IGFBP-3 restrict IGF bioavailability, and excess IGFBPs inhibit IGF action by forming biologically inactive complexes.
M M, Rechler, D R, Clemmons
openaire   +2 more sources

General aspects of insulin-like growth factor binding proteins

Endocrine, 1997
Insulin-like growth factor binding proteins (IGFBPs) belong to a family of at least six homologous proteins that bind insulin-like growth factors (IGFs) and modulate many of their biological actions. IGFBPs are produced by a wide variety of tissues and their circulating levels are regulated by both hormonal and metabolic factors.
K, Chan, E M, Spencer
openaire   +2 more sources

Insulin-like growth factor binding protein (IGFBP) signalling

Growth Hormone & IGF Research, 2004
Insulin-like growth factor-I and -II (IGF-I and -II) are peptides that regulate cell metabolism, growth, differentiation and survival according to physiological requirements and the tissue type involved. They bind to two transmembrane receptors, the type I and type II IGF receptors (IGF-IR and IGF-IIR), although their cellular action is mediated via ...
openaire   +2 more sources

Insulin-like growth factor binding proteins 4-6

Best Practice & Research Clinical Endocrinology & Metabolism, 2015
Insulin-like growth factor binding proteins (IGFBPs) 4-6 have important roles as modulators of IGF actions. IGFBP-4 and IGFBP-6 predominantly inhibit IGF actions, whereas IGFBP-5 may enhance these actions under some circumstances. IGFBP-6 is unique among the IGFBPs for its marked IGF-II binding preference.
openaire   +2 more sources

Insulin-Like Growth Factor Binding Proteins in the Nervous System

1991
Insulin-like growth factor binding proteins (IGFBPs) are a group of discrete but structurally related polypeptides,1–3 which bind and modulate the biological activity of insulin-like growth factors (IGFs) I and II.4–9 Since available evidence suggests that IGF-I and -II participate in growth, metabolism, differentiation, and injury repair,10–24 to name
openaire   +2 more sources

Insulin-like growth factor-binding proteins and bone metabolism

American Journal of Physiology-Endocrinology and Metabolism, 2008
Insulin-like growth factor-binding proteins (IGFBPs) are important regulators of bone metabolism. However, their precise roles are not fully understood, since IGFBPs can have both enhancing and inhibiting effects on IGF action, depending on context and posttranslational modifications, as well as IGF-independent effects.
openaire   +2 more sources

Insulin-Like Growth Factors, Insulin-Like Growth Factor Binding Proteins and Ovarian Androgen Production

Hormone Research, 2008
Increasing evidence indicates that the ovary contains an insulin-like growth factor (IGF) system complete with ligands, binding proteins, and receptors. Through their interaction with IGF receptors on theca-interstitial cell surface membranes, the ligands, IGF-I and IGF-II, synergize with luteinizing hormone (LH) to increase ovarian androgen production.
openaire   +2 more sources