Results 221 to 230 of about 14,817,072 (278)

Three decades of anaplastic lymphoma kinase: from physiological roles to cancer and immune evasion. [PDF]

Cancer Metastasis Rev
Amin HM, Aminnia S, Saber MM, Kannan MK, Hung J.   +4 more
europepmc   +1 more source

From Periodontal Pocket to Systemic Diseases: Mechanistic Insights Into the Role of Porphyromonas gingivalis in Host Pathology. [PDF]

J Cell Mol Med
Basalim AA, Lu EM.
europepmc   +1 more source

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Phosphorylation of insulin-like growth factor binding proteins

Molecular and Cellular Endocrinology, 1997
Insulin-like growth factor (IGF) binding proteins (IGFBPs) play a key role in regulating the availability of IGFs in the circulation and the extracellular environment. Three of these proteins-IGFBP-1, IGFBP-3 and IGFBP-5-are known to be serine-phosphorylated in their central domains, and the others have possible target sites for serine/threonine ...
J A, Coverley, R C, Baxter
openaire   +2 more sources

The Role of Insulin-Like Growth Factor Binding Proteins

Neuroendocrinology, 2006
Insulin-like growth factors (IGFs) are fundamental cell regulators with an evolutionary conserved role synchronising tissue growth, development and function according to metabolic conditions. Although structurally very similar to insulin, the IGFs act in a very different way as cell regulators. Whereas insulin is stored in a specific gland and released
Perks, Claire, Holly, Jeffrey M P
openaire   +3 more sources

Insulin-like growth factor binding protein proteolysis

Trends in Endocrinology & Metabolism, 2003
High-affinity interactions between insulin-like growth factors (IGF-I and IGF-II) and insulin-like growth factor-binding proteins (IGFBP-1, -2, -3, -4, -5 and -6) antagonize the binding of IGF to the type 1 IGF receptor. Proteases found in a variety of biological fluids can degrade IGFBP 1-6 into fragments that have a greatly reduced affinity for IGF-I
R Clay, Bunn, John L, Fowlkes
openaire   +2 more sources

Insulin-like Growth Factor Binding Proteins in Development

2005
IGFBPs regulate growth and development by regulating IGF transport to tissues and IGF bioavailability to IGF receptors at cell membrane level. IGFBP excess leads predominantly to inhibition of IGF action and growth retardation with impaired organogenesis. Absence of human and also mouse ALS leads to decreased IGF-I levels in circulation and causes mild
Josef V, Silha, Liam J, Murphy
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Insulin‐like growth factor‐binding protein 1 and insulin‐like growth factor‐binding protein 3 in pre‐eclampsia

BJOG: An International Journal of Obstetrics & Gynaecology, 1996
Objective To investigate circulating levels of insulin‐like growth factor‐binding protein 1 (IGFBP‐1) and IGFBP‐3 in the mother and the fetus in pregnancies complicated by pre‐eclampsia, and the relationship between serum levels of IGFBPs and fetal birthweight.Design A prospective study over an 18 month period.Setting A tertiary care ...
H S, Wang, J D, Lee, B J, Cheng, Y K, Soong   +3 more
openaire   +2 more sources

Insulin-Like Growth Factor-Binding Proteins and Ovarian Folliculogenesis

Hormone Research, 2008
In the ovary, insulin-like growth factors (IGFs) enhance both proliferation and differentiation of follicular cells by potentiating gonadotropin’s actions. The biological effects of IGFs are strikingly modulated by IGF-binding proteins (IGFBPs), whose levels in follicular fluid dramatically change during folliculogenesis.
Monget, Philippe, Besnard, N., Huet, Camille, Pisselet, C., Monniaux, Danielle   +4 more
openaire   +3 more sources

Insulin‐like growth factor binding proteins: a proposed superfamily

Acta Paediatrica, 1999
Hwa V, Oh Y, Rosenfeld RG. Insulin‐like growth factor binding proteins: a proposed superfamily. Acta Pzdiatr 1999; Suppl 428:37‐45. Stockholm. ISSN 0803‐5326The conventional concept is that the insulin‐like growth factor binding proteins (IGFBPs) are cysteine‐rich proteins, with conserved N‐ and C‐domains, that are capable of binding insulin‐like ...
V, Hwa, Y, Oh, R G, Rosenfeld
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