Results 121 to 130 of about 34,204,101 (306)
Insulin-like growth factor I (IGF-I) in a growth-enhanced transgenic (GH-overexpressing) bony fish, the tilapia (Oreochromis niloticus):: indication for a higher impact of autocrine/paracrine than of endocrine IGF-I
, 2007 Insulin-like growth factor I (IGF-I) in a growth-enhanced transgenic (GH-overexpressing) bony fish, the tilapia (Oreochromis niloticus):: indication for a higher impact of autocrine/paracrine than of endocrine IGF-Natallia Shved (648228), Norman Maclean (16200125), Juergen Zapf (19705540), Azizur M Rahman (19705588), Guylin Hwang (19705537), Elisabeth Eppler (10913934), Manfred Reinecke (16518185), Antje Caelers (19705534) +7 morecore Supplementary Fig. S3 from Antixenograft tumor activity of a humanized anti-insulin-like growth factor-I receptor monoclonal antibody is associated with decreased AKT activation and glucose uptake
, 2008 Supplementary Fig. S3 from Antixenograft tumor activity of a humanized anti-insulin-like growth factor-I receptor monoclonal antibody is associated with decreased AKT activation and glucose ...An Song (10874351), Wei-Ching Liang (1593526), Yonglei Shang (14909469), Kenji Kozuka (5684108), Jean-Philippe Stephan (40079), Yan Wu (70890), Suzie J. Scales (14895671), Congfen Li (11890795), Zora Modrusan (37892), Sang Hoon Lee (211083), Siao Ping Tsai (1958665), Sarajane Ross (14881149), Klaus Hoeflich (15040823), Alexander Vanderbilt (15040820), Gail Phillips (2372092), Jennifer Batson (3719461), Mark R. Lackner (14886740), Avi Ashkenazi (30123), Simon Williams (155614), Zhijun Tang (9643426), Jiping Zha (4917034), Jihong Yang (585406), Yifan Mao (11903012), Christine Tan (15040817), Klara Totpal (14899089), Janet Tien (14894523) +25 morecore +1 more sourceCharting Endocrine Progenitors Across Species and Organs
Advanced Science, EarlyView.Endocrine progenitors give rise to the hormone‐producing cells of the pancreas and intestine. Using single‐cell multiomics and proteomics, this study compares these progenitors across species, systems, and organs, mapping the conserved and species‐specific gene regulatory networks that guide their formation.Changying Jing, Michael Sterr, Özüm Sehnaz Caliskan, Lama Saber, Nicole Katarina Rogers, Samuel Ogden, Kei Kozawa, Christos Karampelias, Jessica Jaki, Aimée Bastidas‐Ponce, Falk Janos Farkas, Oliver Czarnecki, Osvaldo Rodrigues Pereira, Perla Cota, Valerie Vandenbempt, Diego Balboa, Anika Böttcher, Natalie Krahmer, Mohammad Lotfollahi, Julie B. Sneddon, Heiko Lickert, Mostafa Bakhti +21 morewiley +1 more sourceSupplementary Table S3 from Antixenograft tumor activity of a humanized anti-insulin-like growth factor-I receptor monoclonal antibody is associated with decreased AKT activation and glucose uptake
, 2008 Supplementary Table S3 from Antixenograft tumor activity of a humanized anti-insulin-like growth factor-I receptor monoclonal antibody is associated with decreased AKT activation and glucose ...An Song (10874351), Wei-Ching Liang (1593526), Yonglei Shang (14909469), Kenji Kozuka (5684108), Jean-Philippe Stephan (40079), Yan Wu (70890), Suzie J. Scales (14895671), Congfen Li (11890795), Zora Modrusan (37892), Sang Hoon Lee (211083), Siao Ping Tsai (1958665), Sarajane Ross (14881149), Klaus Hoeflich (15040823), Alexander Vanderbilt (15040820), Gail Phillips (2372092), Jennifer Batson (3719461), Mark R. Lackner (14886740), Avi Ashkenazi (30123), Simon Williams (155614), Zhijun Tang (9643426), Jiping Zha (4917034), Jihong Yang (585406), Yifan Mao (11903012), Christine Tan (15040817), Klara Totpal (14899089), Janet Tien (14894523) +25 morecore +1 more sourceEngineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application
Advanced Science, EarlyView.Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs, Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang +6 morewiley +1 more sourceSupplementary Fig. S1 from Antixenograft tumor activity of a humanized anti-insulin-like growth factor-I receptor monoclonal antibody is associated with decreased AKT activation and glucose uptake
, 2008 Supplementary Fig. S1 from Antixenograft tumor activity of a humanized anti-insulin-like growth factor-I receptor monoclonal antibody is associated with decreased AKT activation and glucose ...An Song (10874351), Wei-Ching Liang (1593526), Yonglei Shang (14909469), Kenji Kozuka (5684108), Jean-Philippe Stephan (40079), Yan Wu (70890), Suzie J. Scales (14895671), Congfen Li (11890795), Zora Modrusan (37892), Sang Hoon Lee (211083), Siao Ping Tsai (1958665), Sarajane Ross (14881149), Klaus Hoeflich (15040823), Alexander Vanderbilt (15040820), Gail Phillips (2372092), Jennifer Batson (3719461), Mark R. Lackner (14886740), Avi Ashkenazi (30123), Simon Williams (155614), Zhijun Tang (9643426), Jiping Zha (4917034), Jihong Yang (585406), Yifan Mao (11903012), Christine Tan (15040817), Klara Totpal (14899089), Janet Tien (14894523) +25 morecore +1 more sourceGHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis
Advanced Science, EarlyView.Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu +24 morewiley +1 more sourceSupplementary Table S2 from Antixenograft tumor activity of a humanized anti-insulin-like growth factor-I receptor monoclonal antibody is associated with decreased AKT activation and glucose uptake
, 2008 Supplementary Table S2 from Antixenograft tumor activity of a humanized anti-insulin-like growth factor-I receptor monoclonal antibody is associated with decreased AKT activation and glucose ...An Song (10874351), Wei-Ching Liang (1593526), Yonglei Shang (14909469), Kenji Kozuka (5684108), Jean-Philippe Stephan (40079), Yan Wu (70890), Suzie J. Scales (14895671), Congfen Li (11890795), Zora Modrusan (37892), Sang Hoon Lee (211083), Siao Ping Tsai (1958665), Sarajane Ross (14881149), Klaus Hoeflich (15040823), Alexander Vanderbilt (15040820), Gail Phillips (2372092), Jennifer Batson (3719461), Mark R. Lackner (14886740), Avi Ashkenazi (30123), Simon Williams (155614), Zhijun Tang (9643426), Jiping Zha (4917034), Jihong Yang (585406), Yifan Mao (11903012), Christine Tan (15040817), Klara Totpal (14899089), Janet Tien (14894523) +25 morecore +1 more sourceGm26550 Modulates Learning and Memory by Increasing IGF1 mRNA Expression and Stability in Nrf2−/− Mice
Advanced Science, EarlyView.The present study shows that Nrf2 directly binds to the Gm26550 promoter, thereby activating Gm26550 transcription and increasing its expression. Mechanistically, Gm26550 promotes IGF1 expression by functionally antagonizing miR‐26a‐5p‐mediated repression and sequestering the RBP KHSRP, thereby enhancing hippocampal neuronal synaptic plasticity and ...Hongfang Wang, Ziyao Wang, Dongyue Zuo, Zhaowen Su, Bowen Song, Jiamin Gao, Yizhou Zhang, Ruiting Zhao, Linjie Sun, Mengdi Li, Yirui Fan, Dandan Geng, Lei Wang +12 morewiley +1 more source