How does thymus infection by coxsackievirus contribute to the pathogenesis of type 1 diabetes?
Frontiers in Immunology, 2015 Through synthesis and presentation of neuroendocrine self-antigens by major histocompatibility complex (MHC) proteins, thymic epithelial cells (TECs) play a crucial role in programming central immune self-tolerance to neuroendocrine functions.
Hélène eMichaux +5 more
doaj +1 more source
Insulin-like Growth Factors in a clinical setting: Review of IGF-I
Biomedical Papers, 2015 Background and Aims: Interest in growth hormone (GH) is inextricably linked to the need for in depth understanding of the somatomedins (insulin-like growth factors) which are polypeptides structurally similar to insulin and with broad physiological ...
Zdenek Frysak +3 more
doaj +1 more source
Identification of antigenic targets of paraproteins by expression cloning does not support a causal role of chronic antigenic stimulation in the pathogenesis of multiple myeloma and MGUS [PDF]
, 2007 Antigenic targets of monoclonal gammopathy of undetermined significance (MGUS) and multiple myeloma (MM) paraproteins have been suggested to play an important role as growth stimulators in the pathogenesis of these neoplasms. To identify such targets, we
Braun +19 more
core +2 more sources
Nutrition & Metabolism, 2012 s Background and objective The study was performed to determine whether catch-up growth is associated with the development of insulin resistance and to explore serum endocrine markers associated with the metabolism of adipose tissue in a Chinese ...
Deng Hong-Zhu +6 more
doaj +1 more source
The Journal of Poultry Science, 2018 Autophagy, an intracellular bulk protein degradation system in skeletal muscle, is increased under catabolic conditions resulting in muscle atrophy. This study aimed to investigate the effects of insulin, insulin-like growth factor (IGF)-I, and amino ...
Kazuki Nakashima, Aiko Ishida
doaj +1 more source
Molecular evolution of growth hormone [PDF]
, 2014 Growth hormone (GH) is a single-chain protein hormone of about 190 residues, expressed mainly in the vertebrate anterior pituitary gland, which regulates somatic growth and various aspects of metabolism; many of these actions are mediated by insulin ...
Wallis, Michael
core
The effects of graded levels of calorie restriction : II. Impact of short term calorie and protein restriction on circulating hormone levels, glucose homeostasis and oxidative stress in male C57BL/6 mice [PDF]
, 2015 This work was supported by BBSRC BB009953/1 awarded to JRS and SEM. PK and CD were funded by the Erasmus exchange programme. JRS, SEM, DD, CG, LC, JJDH, YW, DELP, DL and AD are members of the BBSRC China Partnership Award, BB/J020028/1.Peer ...
Chen, Luonan +12 more
core +2 more sources
Insulin-like Growth Factor II mRNA-Binding Protein 1 Regulates Pancreatic Cancer Cell Growth through the Surveillance of CDC25A mRNA. [PDF]
Cancers (Basel), 2023 Di Fusco D +9 more
europepmc +1 more source
A novel tumour enhancer function of Insulin-like growth factor II mRNA-binding protein 3 in colorectal cancer. [PDF]
Cell Death Dis, 2023 Di Fusco D +10 more
europepmc +1 more source
Pesquisa Brasileira em Odontopediatria e Clínica IntegradaObjective: To estimate the serum levels of non-radiologic biomarkers, Insulin-like Growth Factor-1 (IGF-1), and Insulin-like Growth Factor Binding Protein-3 (IGFBP-3) to potentially identify the pubertal growth spurt in skeletal Class II malocclusion ...
Arif Yezdani +2 more
doaj