Results 171 to 180 of about 18,925,600 (331)

OTUD6A‐Mediated Deubiquitination of PRDX1 Protects Against Oral Ulcer by Restoring Mitochondrial Function

Advanced Science, EarlyView.
In human oral keratinocytes, OTUD6A promoted cell migration by deubiquitinating and stabilizing PRDX1. Conversely, OTUD6A deficiency reduced PRDX1 stability, triggering mitochondrial dysfunction and aggravating OU progression. ABSTRACT Oral ulcers (OU), as the most highly prevalent and recurrent oral mucosal lesion, have an unclear pathogenesis that ...
Xiaoyu Sun, Ruiwei Jia, Xingbei Pan, Rui Huang, Jiahong Chen, Ziyi Yao, Lei Yin, Jun Ma, Hongjieliang Wang, Xinyu Huang, Yilin Ma, Yifan Ping, Yuanyuan Chen, Huining Wang, Shengbin Huang, Guang Liang   +15 more
wiley   +1 more source

Association of Serum Cytokines, Human Growth Hormone, Insulin-Like Growth Factor (IGF)-I, IGF-II and IGF-Binding Protein (IGFBP)-3 with Coronary Artery Disease

, 2012
[[abstract]]The roles that serum cytokines, human growth hormone (h-GH), insulin-like growth factor (IGF)-I, IGF-II and IGF-binding protein (IGFBP)-3 play in coronary artery disease (CAD) are not completely clear. A total of 80 participants comprising 20
黃志揚;HUANG, CHIH-YANG
core  

Regulating Cells Fate and Function to Facilitate Bone Regeneration via Designing Programmable Bio‐Interactive Materials

Advanced Science, EarlyView.
This article aims to elucidate the biological mechanisms of bone repair and the evolution of material design, highlighting key cellular and molecular processes. It further proposes strategies and prospects for programmable bio‐interactive materials, which enable precisely guided bone tissue regeneration by dynamically regulating cell behavior and the ...
Qingrui Fan, Fuming Cao, Junqiang Mao, Pengbin Yin, Licheng Zhang, Jianjun Wang, Peifu Tang   +6 more
wiley   +1 more source

Regulation of the Imprinted Mouse Insulin-like Growth Factor II Gene by Distal Enhancers

Contents Abstract Chapter 1.Enhancer-dependent,Locus-wideRegulation of the Imprinted Mouse Insulin-like Growth Factor II Gene Chapter 2.Identification of a New Enhancer Potentially Involved in the Regulation of the Mouse Insulin-like Growth Factor II ...
Hatano, Naoya, 波多野, 直哉, ハタノ, ナオヤ   +2 more
core  

Insulin-like growth factor II acts through an endogenous growth pathway regulated by imprinting in early mouse embryos.

Genes & Development, 1992
D. A. Rappolee, K. Sturm, O. Behrendtsen, Gilbert A. Schultz, Roger A. Pedersen, Z. Werb   +5 more
semanticscholar   +1 more source

Polystyrene Nanoplastics Drive β‐Cell Dedifferentiation Through Dendritic Cell‐Intrinsic MHC‐I‐Dependent Inflammatory Crosstalk

Advanced Science, EarlyView.
Polystyrene nanoplastics disrupt pancreatic immune–endocrine homeostasis by promoting MHC‐I‐associated dendritic cell activation and inflammatory crosstalk with β cells. This immune remodeling drives β‐cell dedifferentiation, impairs insulin secretion, and aggravates metabolic dysfunction, revealing a previously unrecognized immunometabolic mechanism ...
Conghui Qiao, Yuqing Song, Fang Yang, Menghui Guo, Libin Jiang, Xiaoyue Quan, Wei Wei, Xinyang Wang, Tianshu Han, Mingyuan Liu, Wenbo Jiang   +10 more
wiley   +1 more source

Emerging role of insulin-like growth factor-binding protein 7 in hepatocellular carcinoma

, 2014
Maaged Akiel, Devaraja Rajasekaran, Rachel Gredler, Ayesha Siddiq, Jyoti Srivastava, Chadia Robertson, Nidhi Himanshu Jariwala, Paul B Fisher, Devanand SarkarDepartment of Human and Molecular Genetics, Massey Cancer Center, VCU Institute of Molecular ...
Robertson C, Akiel M, Rajasekaran D, Jariwala NH, Fisher PB, Sarkar D, Siddiq A, Srivastava J, Gredler R   +8 more
core  

Dwarfism and Impaired Gut Development in Insulin-Like Growth Factor II mRNA-Binding Protein 1-Deficient Mice

Molecular and Cellular Biology, 2004
T. Hansen, Niels A Hammer, J. Nielsen, Mette Madsen, Charlotte Dalbaeck, U. Wewer, J. Christiansen, F. Nielsen   +7 more
semanticscholar   +1 more source

Programmable Paracrine‐Mimetic Microneedle System for Temporal Regulation of Cardiac Repair

Advanced Science, EarlyView.
Temporal signaling is encoded into a programmable paracrine‐mimetic microneedle patch via tris(2,2'‐bipyridyl)dichlororuthenium(II) hexahydrate/sodium persulfate‐tuned hydrogel microparticles that deliver TGF‐β, IGF‐1, and VEGF over phase‐matched 7‐, 14‐, and 28‐day windows.
Yichen Dai, Pengchong Du, Zhaoyang Wang, Surilige, Rangga Fokta, Renjian Tan, Xiqing Zhao, Shuoyi Zhang, Yuecheng Wang, Yixin Zhang, Ziliang Fu, Rui Gong, Cheng Jiang, Yisheng He, Qiguang Wang, Renke Li, Khoon Lim, Junnan Tang, Xiaolin Cui   +18 more
wiley   +1 more source

Human Insulin-Like Growth Factor II mRNA-Binding Protein 3 (IMP3) and p16 Expression in Squamous Cell Carcinoma of the Head and Neck. [PDF]

Cureus
Calaisselvane U, Manuel K, Ambroise MM, Venkatesan SK.   +3 more
europepmc   +1 more source