Results 101 to 110 of about 830,008 (409)

Current trends in single‐cell RNA sequencing applications in diabetes mellitus

FEBS Open Bio, EarlyView.
Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian, Khodakaram Jahanbin, Shekoofeh Nikooei, Marzieh Rostaminejad, Arezoo Rahimi, Pedram Abdizadeh, Behnam Alipoor   +6 more
wiley   +1 more source

Pregnancy rates and metabolic profiles in cattle treated with propylene glycol prior to embryo transfer [PDF]

, 2011
The objective of this study was to determine the effect of a sustained propylene glycol administration to recipients of frozen/thawed in vivo derived bovine embryos.
Duque, Paloma, Díez, Carmen, Facal, Nieves, Fernández, Itziar, Fernández, Lina, Goyache, Félix, Gómez, Enrique, Olegario, Carlos, Prieto, Lupicinio   +8 more
core  

Insulin-like growth factor I is an independent coregulatory modulator of natural killer (NK) cell activity. [PDF]

, 1996
We aimed to investigate the natural killer (NK) cell activity in hGH-deficient adults and to analyze the effect of insulin-like growth factor (IGF)-I in uivo and in vitro on NK cell activity.
C J Auernhammer, C J Strasburger, H Feldmeier, K Pachmann, R Nass   +4 more
core   +1 more source

Insulin‐like growth factor 1 has multisystem effects on foetal and preterm infant development

Acta paediatrica, 2016
Poor postnatal growth after preterm birth does not match the normal rapid growth in utero and is associated with preterm morbidities. Insulin‐like growth factor 1 (IGF‐1) axis is the major hormonal mediator of growth in utero, and levels of IGF‐1 are ...
A. Hellström, D. Ley, I. Hansen-Pupp, B. Hallberg, Chatarina Löfqvist, Linda van Marter, M. van Weissenbruch, L. Ramenghi, K. Beardsall, D. Dunger, A. Hård, Lois E. H. Smith   +11 more
semanticscholar   +1 more source

Co‐overexpression of the caloric restriction‐induced mitochondrial factors PGC‐1α and MIPEP upregulates Phospho1 expression in adipocytes

FEBS Open Bio, EarlyView.
Caloric restriction that extends lifespan induces the expression of PGC‐1α and MIPEP in white adipose tissue. In this study, co‐overexpression of Pgc‐1α and Mipep upregulated the gene expression of PHOSPHO1. These findings provide new insights into mitochondria‐related mechanisms underlying the effects of caloric restriction in adipocytes.
Mamiko Ishimatsu, Kanari Taki, Asuka Hayami, Komachi Kato, Yuka Nozaki, Yuhei Mizunoe, Takumi Narita, Ryoichi Mori, Yoshikazu Higami, Masaki Kobayashi   +9 more
wiley   +1 more source

Insulin and insulin-like growth factor-1 induce pronounced hypertrophy of skeletal myofibers in tissue culture [PDF]

Skeletal myofibers differentiated from primary avian myoblasts in tissue culture can be maintained in positive nitrogen balance in a serum-free medium for at least 6 to 7 days when embedded in a three dimensional collagen gel matrix.
Karlisch, Patricia, Shansky, Janet, Vandenburgh, Herman H.   +2 more
core   +1 more source

Insulin-like growth factor-1 in CNS and cerebrovascular aging [PDF]

, 2013
Insulin-like growth factor-1 (IGF-1) is an important anabolic hormone that decreases with age. In the past two decades, extensive research has determined that the reduction in IGF-1 is an important component of the age-related decline in cognitive ...
Anna Csiszar, Ferenc Deak, Nicole Ashpole, Peter Toth, Willard Freeman, William E. Sonntag, Zoltan Ungvari   +6 more
core   +2 more sources

Do insulin-like growth factor associated proteins qualify as a tumor marker? results of a prospective study in 163 cancer patients*

European Journal of Medical Research, 2011
Objective Insulin-like growth factor (IGF)-1, -2 and Insulin like growth factor binding proteins (IGFBP) are involved in the proliferation and differentiation of cells.
Matuschek G, Rudoy M, Peiper M, Gerber PA, Hoff NP, Buhren BA, Flehmig B, Budach W, Knoefel WT, Bojar H, Prisack HB, Steinbach G, Shukla V, Schwarz A, Kammers K, Erhardt A, Scherer A, Bölke E, Schauer M   +18 more
doaj   +1 more source

Liver‐specific lncRNAs associated with liver cancers

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) are regulatory molecules with various functions. They are more tissue‐specific than proteins and can be used as potential biomarkers, particularly in cancer diagnostics and prognosis. In this review, we have systematically compiled all lncRNAs with exclusive expression in the human liver, verified their liver specificity ...
Olga Y. Burenina, Roman K. Makarchenko, Maria P. Rubtsova, Olga A. Dontsova   +3 more
wiley   +1 more source

Insulin-Like Growth Factor System in Cancer: Novel Targeted Therapies

BioMed Research International, 2015
Insulin-like growth factors (IGFs) are essential for growth and survival that suppress apoptosis and promote cell cycle progression, angiogenesis, and metastatic activities in various cancers. The IGFs actions are mediated through the IGF-1 receptor that
V. Brahmkhatri, C. Prasanna, H. Atreya
semanticscholar   +1 more source