Results 111 to 120 of about 830,008 (409)

Metabolic Consequences of Rheumatoid Arthritis

Arthritis Care &Research, EarlyView.
Patients with rheumatoid arthritis (RA) may have metabolic disruption, which can contribute to adverse long‐term outcomes, for multiple reasons. Patients with RA appear to have a higher risk of sarcopenia, type 1 and type 2 diabetes mellitus, metabolic syndrome, and hypertension. Systemic inflammation in RA can cause a “lipid paradox,” with reduced low‐
Stevie Barry, Emily Sheng, Joshua F. Baker   +2 more
wiley   +1 more source

Insulin-like growth factor-I receptor signaling and resistance to trastuzumab (Herceptin).

Journal of the National Cancer Institute, 2001
BACKGROUND Trastuzumab (Herceptin), an anti-HER2/neu receptor monoclonal antibody that inhibits growth of ErbB2-overexpressing breast cancer, is used to treat such cancers. Development of resistance to trastuzumab, however, is common.
Yuhong Lu, X. Zi, Yunhua Zhao, D. Mascarenhas, M. Pollak   +4 more
semanticscholar   +1 more source

LIN28B Promotes Cancer Cell Dissemination and Angiogenesis

Advanced Biology, EarlyView.
Children diagnosed with high‐risk neuroblastoma have a 5‐year event‐free survival rate of less than 50% and poor outcomes after recurrence. Deregulation of the LIN28B oncogene can be addressed in these patients. Upregulation of LIN28B is shown to support the metastatic cascade.
Diana Corallo, Sara Menegazzo, Marcella Pantile, Silvia Bresolin, Carlo Zanon, Alessandro Davini, Massimiliano Mazzone, Alessandra Biffi, Sanja Aveic   +8 more
wiley   +1 more source

The use of insulin-like growth factor 1 improved the parameters of the seminogram in a patient with severe oligoasthenoteratozoospermia

SAGE Open Medical Case Reports, 2019
Male patients suffering from oligoasthenoteratozoospermia typically failed to achieve pregnancy, even with assisted reproductive technologies. Growth hormone and insulin-like growth factor 1 have been shown to regulate sperm quality parameters; therefore,
José Arturo Mora Rodríguez, Leonardo M Porchia, Felipe Camargo, Esther López-Bayghen   +3 more
doaj   +1 more source

Insulin-like growth factor-1 deficiency and metabolic syndrome

Journal of Translational Medicine, 2016
Consistent evidence associates IGF-1 deficiency and metabolic syndrome. In this review, we will focus on the metabolic effects of IGF-1, the concept of metabolic syndrome and its clinical manifestations (impaired lipid profile, insulin resistance ...
G. Aguirre, J. R. D. Ita, R. D. L. Garza, I. Castilla-Cortázar   +3 more
semanticscholar   +1 more source

Microphysiological Glomerular Filtration Barriers: Current Insights, Innovations, and Future Applications

Advanced Biology, EarlyView.
The glomerular filtration barrier (GFB) is the first step of blood filtration by the kidneys. The concerning increase of kidney diseases makes the development of new models essential. In this context, microphysiological glomerular filtration barriers focus on closely reproducing the physiological architecture of the in vivo GFB: podocytes, glomerular ...
Manon Miran, Kieu Ngo, David Buob, Hanna Debiec, Pierre Ronco, Guillaume Perry   +5 more
wiley   +1 more source

Insulin-like growth factor - Oestradiol crosstalk and mammary gland tumourigenesis [PDF]

, 2013
Development and differentiation of the mammary gland are dependent on the appropriate temporal expression of both systemically acting hormones and locally produced growth factors.
Adamo, Ahmed, Ahn, Akekawatchai, Arteaga, Arteaga, Arteaga, Atsriku, Baege, Barone, Beattie, Becker, Bentel, Blakesley, Boylan, Burrows, Butt, Carboni, Carmeci, Casa, Castoria, Chen, Chen, Christopher Twelves, Clarke, Cui, Cullen, Davidson, De Leon, De Leon, De Leon, De Leon, De Marco, Dickson, Dubois, Espelund, Fagan, Fan, Figueroa, Fontana, Foulstone, Fowler, Fox, Freed, Furlanetto, Gaben, Gee, Genua, Ghayad, Gibson, Goldstein, Gooch, Goodwin, Gualberto, Hermani, Huff, Huynh, Huynh, Huynh, James Beattie, Jiralerspong, Joel, Kahlert, Kamanga-Sollo, Karey, Kato, Kim, Klotz, Knowlden, Koos, Lee, Lee, Leong, Levin, Lippman, Manni, Maor, Martin, Martin, Massarweh, Mathieu, Mawson, Maxwell, McCaig, McCotter, McGuire, McIntosh, Medunjanin, Mendoza, Milazzo, Minuto, Morelli, Morgan, Muck, Murphy, Murphy, Murphy, Naing, Neuenschwander, Oh, Osborne, Osborne, Osborne, Pandini, Panno, Parisot, Peng, Perks, Perks, Phillips, Picard, Pollak, Pratt, Pritchard, Prossnitz, Reem El-Gendy, Richards, Robertson, Rohlik, Rowzee, Ruan, Sachdev, Salahifar, Sano, Santen, Sheikh, Sheikh, Sheikh, Shukla, Siddle, Simoncini, Sisci, Song, Song, Song, Song, Stewart, Tharakan, Thomas, Thorsen, Tian, Tremblay, Tsonis, Valerie Speirs, van den Berg, Westley, Wilson, Wiseman, Yang, Yee, Yee, Yee, Yee, Yee, Yee, Yousef Hawsawi, Zapf   +156 more
core   +1 more source

Induction of apoptosis in cerebellar granule neurons by low potassium: inhibition of death by insulin-like growth factor I and cAMP.

Proceedings of the National Academy of Sciences of the United States of America, 1993
High levels of extracellular K+ ensure proper development and prolong survival of cerebellar granule neurons in culture. We find that when switched from a culture medium containing high K+ (25 mM) to one containing a low but more physiological K ...
S. D’Mello, C. Galli, T. Ciotti, P. Calissano   +3 more
semanticscholar   +1 more source

Key Trends and Insights in Smart Polymeric Skin Wearable Patches

Advanced Engineering Materials, EarlyView.
Intelligent polymers, which respond to various physical and biological stimuli, are explored for the development of skin wearable patches in biomedical applications. Smart polymers, also known as intelligent or stimuli‐responsive polymers, play a crucial role in the development of advanced wearable patches due to their versatility and softness.
Sergio J. Peñas‐Núñez, Rajat Rai, Miryam Criado‐Gonzalez   +2 more
wiley   +1 more source

Исследование инсулиноподобного фактора роста-1 в регенерации кости [PDF]

, 2012
У статті автори аналізують результати експериментального застосування інсуліноподібного фактору росту-1 для стимуляції репаративного остеогенезу на 12 білих лабораторних щурах.
Дедух, Н.В., Подлипенцев, В.В., Тихоненко, А.А., Хмызов, С.А.   +3 more
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