Results 301 to 310 of about 830,008 (409)

MYC/TET3‐Regulated TMEM65 Activates OXPHOS‐SERPINB3 Pathway to Promote Progression and Cisplatin Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Triple‐negative breast cancer (TNBC) remains a major challenge in breast cancer management as it lacks effective therapeutic targets. This study uncovers that MYC/TET3‐regulated mitochondrial inner‐membrane protein TMEM65 promotes TNBC progression and cisplatin resistance by activating the OXPHOS‐SERPINB3 pathway and reveals TMEM65 as a potential ...
Yin‐Ling Zhang, Min‐Ying Huang, Shao‐Ying Yang, Jia‐Yang Cai, Qian Zhao, Fang‐Lin Zhang, Xin Hu, Zhi‐Min Shao, Li Liao, A‐Yong Cao, Da‐Qiang Li   +10 more
wiley   +1 more source

Multifaceted roles of insulin‑like growth factor 2 mRNA binding protein 2 in human cancer (Review). [PDF]

Mol Med Rep
Shen J, Ding Y.
europepmc   +1 more source

Expression and characterization of a functional human insulin-like growth factor I receptor.

, 1988
George Steele-Perkins, Jeffrey D. Turner, Jeffrey C. Edman, Joji Hari, Sarah B. Pierce, Cynthia Stover, William J. Rutter, Richard A. Roth   +7 more
openalex   +1 more source

QSOX2‐Mediated Disulfide Bond Modification Enhances Tumor Stemness and Chemoresistance by Activating TSC2/mTOR/c‐Myc Feedback Loop in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
High QSOX2 enhances stemness, drug resistance, and metastasis of ESCC cells. QSOX2‐mediated disulfide bond modification activates mTOR/c‐Myc signaling. CAFs‐secreted IGF‐1 drives mTOR/c‐Myc/QSOX2 positive feedback loop. Combining Ebselen, rapamycin, and cisplatin induces tumor dormancy in mice.
Wo‐Ming Chen, Xiao‐Ping Zhang, Xiao Sun, Hai‐Cheng Liu, Yuan‐Yuan Yan, Xue Wei, Yu Liang, Yue Feng, Zhengjie Chen, Yongxu Jia, Chen Jiang, Qian Yan, Lei Li   +12 more
wiley   +1 more source

Role of insulin-like growth factor-2 in Alzheimer's disease induced memory impairment and underlying mechanisms. [PDF]

Front Cell Neurosci
Chen R, Lu X, Xiao A, Ma J.
europepmc   +1 more source

Targeting IGF1R Overcomes Armored and Cold Tumor Microenvironment and Boosts Immune Checkpoint Blockade in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
IGF1R is highly expressed in the armored & cold tumors, and collagen mediates IGF1R at the transcriptional and post‐translational levels to promote TNBC cell invasion and immune escape and to stabilize its own structure by interacting with the collagen receptor DDR1.
Mengyun Wan, Jie Mei, Yun Cai, Ji Zhou, Ningyi Xue, Ying Jiang, Yan Zhang, Jingjing Huang, Yichao Zhu   +8 more
wiley   +1 more source

Lower Initial Insulin-like Growth Factor-Binding Protein-3 Concentrations May Reflect Immune Suppression and Predict Increased Risk of Sepsis-Related Mortality. [PDF]

Int J Mol Sci
Mearelli F, Nunnari A, Chitti F, Rombini A, Macor A, Denora D, Messana L, Scardino M, Martini I, Bolzan G, Spagnol F, Casarsa C, Fiotti N, Zerbato V, Di Bella S, Tascini C, Di Girolamo FG, Sturma M, Costantino V, Biolo G.   +19 more
europepmc   +1 more source

Post‐Translational Modified Neoantigens in Autoimmune Diseases: Challenges of Immune Tolerance

Advanced Science, EarlyView.
Autoimmune diseases have a high incidence and disability rate. The pathogenesis of autoimmune diseases involves the interaction among genetic factors, environmental factors, and immune disorders. The post‐translational modified neoantigens are the key nodal of these three factors. And these post‐translational modified neoantigens, after being presented
Yue Zhai, Kefei Wu, Qi Lin, Zhenzhen Cao, Yankun Jia, Ping Zhu   +5 more
wiley   +1 more source

Correlation of tri-ponderal mass index with insulin-like growth factor-I and insulin-like growth factor binding protein-3 in children and adolescents. [PDF]

Ann Pediatr Endocrinol Metab
Choi IH, Kim SY, Kim M.
europepmc   +1 more source