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Insulin/insulin-like growth factor signaling pathway promotes higher fat storage inDrosophilafemales
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The Insulin-Like Growth Factors
Annual Review of Physiology, 1993"The insulin-like growth factors (IGF-I and IGF-II) are single-chain polypeptides with structural homology to proinsulin. They regulate proliferation and differentiation of a multitude of cell types and are capable of exerting insulin-like metabolic effects.
David R. Clemmons, W. S. Cohick
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Annals of the New York Academy of Sciences, 1993
The purpose of this review has been to emphasize, in general terms, the major aspects of the structure, expression, and regulation of the IGF-I and IGF-II genes. The complex organization of these genes provides ample opportunities for control of gene expression at multiple levels.
Derek LeRoith, Charles T. Roberts
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The purpose of this review has been to emphasize, in general terms, the major aspects of the structure, expression, and regulation of the IGF-I and IGF-II genes. The complex organization of these genes provides ample opportunities for control of gene expression at multiple levels.
Derek LeRoith, Charles T. Roberts
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2008
In autism, disruption of normal neurobiological mechanisms is found, but it is not known which specific developmentally important molecules might be involved in this disorder. Increased cerebral volume or brain weight is found across studies in autism.
Ruslan Novosyadlyy, Derek LeRoith
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In autism, disruption of normal neurobiological mechanisms is found, but it is not known which specific developmentally important molecules might be involved in this disorder. Increased cerebral volume or brain weight is found across studies in autism.
Ruslan Novosyadlyy, Derek LeRoith
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Insulin‐Like Growth Factor Receptors
Acta Paediatrica, 1991AbstractCompetitive binding experiments from a number of laboratories showed that IGF receptors are distinct from insulin receptors, and that there are two types of IGF receptors based on their relative affinities for IGF-I and IGF-II and whether or not they bind insulin (reviewed in Rechler and Nissley, 1985).
E. K. Neely +4 more
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Cell Biology International, 1995
ABSTRACTThe insulin‐like growth factors I and II are single chain polypeptides homologous to proinsulin. IGF I and IGF II contribute to cell regulation and stimulate protein synthesis via signaling through type I receptors which are homologous to insulin receptors and activate phosphorylation cascades.
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ABSTRACTThe insulin‐like growth factors I and II are single chain polypeptides homologous to proinsulin. IGF I and IGF II contribute to cell regulation and stimulate protein synthesis via signaling through type I receptors which are homologous to insulin receptors and activate phosphorylation cascades.
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1990
Until recently, insulin-like growth factors (or, as they were originally known, somatomedins) were thought to be produced in the liver in response to growth hormone, to circulate in the blood, and to mediate the effects of growth hormone (GH) on skeletal cartilage to promote bone elongation during childhood (Salmon and Daughaday 1957).
M. M. Rechler, S. P. Nissley
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Until recently, insulin-like growth factors (or, as they were originally known, somatomedins) were thought to be produced in the liver in response to growth hormone, to circulate in the blood, and to mediate the effects of growth hormone (GH) on skeletal cartilage to promote bone elongation during childhood (Salmon and Daughaday 1957).
M. M. Rechler, S. P. Nissley
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The Insulin-like Growth Factors and the Lung
American Journal of Respiratory Cell and Molecular Biology, 1990The insulin-like growth factors (IGF-I and IGF-II) are peptides of about 7,500 D with structural homology to proinsulin that are capable of stimulating cellular proliferation and inducing differentiation. They are each encoded by single, large, complex genes that direct the transcription of multiple mRNAs.
Alan D. Stiles, D'Ercole Aj
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Insulin-like growth factors and cancer
The Lancet Oncology, 2002Interest in insulin-like growth factors (IGFs) and their effect on carcinogenesis has increased recently because high serum concentrations of IGF1 are associated with an increased risk of breast, prostate, colorectal, and lung cancers. Physiologically, IGF1 is the major mediator of the effects of the growth hormone; it thus has a strong influence on ...
Hans-Jörg Senn, Gregor Fürstenberger
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