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Actions of Insulin-Like Growth Factors
Annual Review of Physiology, 1985Three different lines of research and three entirely different observations have led to the discovery of the insulin-like growth factors (IGFs). In 1957, Salmon & Daughaday carried out an important experiment (44). They observed that serum stimulated the incorporation of 35S into incubated cartilage.
Christoph Schmid +3 more
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1996
The insulin-like growth factor family of peptides, binding proteins and receptors is involved in normal growth and development. Later they are important in the differentiated function of a number of tissues. Aberrations in this growth factor system are associated with different diseases, ranging from short stature and diabetes to malignancy.
Derek LeRoith, Carolyn A. Bondy
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The insulin-like growth factor family of peptides, binding proteins and receptors is involved in normal growth and development. Later they are important in the differentiated function of a number of tissues. Aberrations in this growth factor system are associated with different diseases, ranging from short stature and diabetes to malignancy.
Derek LeRoith, Carolyn A. Bondy
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Insulin-Like Growth Factors and Aging
Endocrinology and Metabolism Clinics of North America, 1987Since its proposal three decades ago, the evidence in favor of the somatomedin hypothesis has been compelling. It is clear that somatotrophic actions of growth hormone are mediated through generation of insulin-like peptides and interaction of these peptides with plasma membrane receptors on sensitive cells. It is possible that such actions result from
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Insulin-like Growth Factors and Cancer
Annals of Internal Medicine, 1995The insulin-like growth factor (IGF) family of peptides, binding proteins, and receptors are important for normal human growth and development and are involved in the specialized functions of most physiologic systems. Most members of the IGF system are expressed by different cancer cells and may play an important role in the propagation of these ...
Renato Baserga +3 more
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Downstream Insulin-Like Growth Factor
2012Until 10 years ago genetic defects that cause a child to be born small for gestational age (SGA) were poorly defined. With the first descriptions of patients born small for gestational age carrying mutations within the insulin-like growth factor type 1 receptor (IGF-1R) gene, genetic defects at the lower end of the GH-IGF-1 axis were identified as a ...
Wieland Kiess +2 more
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Insulin-like growth factors in poultry
Domestic Animal Endocrinology, 1997A large amount of research, primarily in mammals, has defined to a great extent the pleiotropic effects of the IGF system on growth, development, and intermediary metabolism. Similar elucidations in poultry were hindered to some extent by the absence of native peptides (IGF-I and IGF-II) until their purification, followed by the production of ...
Zee Upton, John P. McMurtry, G L Francis
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Insulin-like growth factors and neoplasia
Nature Reviews Cancer, 2004The insulin-like growth factor 1 (IGF1) signalling pathway has important roles in regulating cellular proliferation and apoptosis. Converging results from epidemiological research and in vivo carcinogenesis models indicate that high levels of circulating IGF1 are associated with increased risk of several common cancers.
Michael Pollak +2 more
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Insulin-like Growth Factors and the Basis of Growth
New England Journal of Medicine, 2003Growth in any species is an extraordinarily complex process, but growth in humans is characterized by a number of unique features.
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Insulin-like growth factors in obstetrics
Current Opinion in Obstetrics and Gynecology, 2000Data from a number of studies reported during the past two decades indicate that the insulin-like growth factor (IGF) system, including IGF-I and IGF-II, their receptors and six high-affinity binding proteins, is involved in the control of foetal and placental growth and development. Recent studies that addressed the role of the IGF system in pregnancy
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The Phylogeny of the Insulin-like Growth Factors
1998The insulin-like growth factors are major regulators of growth and development in mammals and their presence in lower vertebrates suggests that they played a similarly fundamental role throughout vertebrate evolution. While originally perceived simply as mediators of growth hormone, on-going research in mammals has revealed several hierarchical layers ...
Manfred Reinecke, Christopher Collet
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