Results 341 to 350 of about 830,008 (409)
Some of the next articles are maybe not open access.
The Insulin-Like Growth Factors
Annual Review of Physiology, 1993"The insulin-like growth factors (IGF-I and IGF-II) are single-chain polypeptides with structural homology to proinsulin. They regulate proliferation and differentiation of a multitude of cell types and are capable of exerting insulin-like metabolic effects.
David R. Clemmons, W. S. Cohick
openaire +2 more sources
2008
In autism, disruption of normal neurobiological mechanisms is found, but it is not known which specific developmentally important molecules might be involved in this disorder. Increased cerebral volume or brain weight is found across studies in autism.
Ruslan Novosyadlyy, Derek LeRoith
openaire +3 more sources
In autism, disruption of normal neurobiological mechanisms is found, but it is not known which specific developmentally important molecules might be involved in this disorder. Increased cerebral volume or brain weight is found across studies in autism.
Ruslan Novosyadlyy, Derek LeRoith
openaire +3 more sources
Annals of the New York Academy of Sciences, 1993
The purpose of this review has been to emphasize, in general terms, the major aspects of the structure, expression, and regulation of the IGF-I and IGF-II genes. The complex organization of these genes provides ample opportunities for control of gene expression at multiple levels.
Derek LeRoith, Charles T. Roberts
openaire +3 more sources
The purpose of this review has been to emphasize, in general terms, the major aspects of the structure, expression, and regulation of the IGF-I and IGF-II genes. The complex organization of these genes provides ample opportunities for control of gene expression at multiple levels.
Derek LeRoith, Charles T. Roberts
openaire +3 more sources
Molecular and cellular aspects of the insulin-like growth factor I receptor.
Endocrine reviews, 1995I. Introduction THE insulin-like growth factors (IGFs) and their receptors and binding proteins constitute a family of cellular modulators that play essential roles in the regulation of growth and development.
D. Leroith +3 more
semanticscholar +1 more source
Insulin‐Like Growth Factor Receptors
Acta Paediatrica, 1991AbstractCompetitive binding experiments from a number of laboratories showed that IGF receptors are distinct from insulin receptors, and that there are two types of IGF receptors based on their relative affinities for IGF-I and IGF-II and whether or not they bind insulin (reviewed in Rechler and Nissley, 1985).
E. K. Neely +4 more
openaire +5 more sources
Cell Biology International, 1995
ABSTRACTThe insulin‐like growth factors I and II are single chain polypeptides homologous to proinsulin. IGF I and IGF II contribute to cell regulation and stimulate protein synthesis via signaling through type I receptors which are homologous to insulin receptors and activate phosphorylation cascades.
openaire +3 more sources
ABSTRACTThe insulin‐like growth factors I and II are single chain polypeptides homologous to proinsulin. IGF I and IGF II contribute to cell regulation and stimulate protein synthesis via signaling through type I receptors which are homologous to insulin receptors and activate phosphorylation cascades.
openaire +3 more sources
Plasma Insulin-Like Growth Factor-I and Prostate Cancer Risk: A Prospective Study
, 1998Insulin-like growth factor-I (IGF-I) is a mitogen for prostate epithelial cells. To investigate associations between plasma IGF levels and prostate cancer risk, a nested case-control study within the Physicians' Health Study was conducted on ...
J. Chan +7 more
semanticscholar +1 more source
1990
Until recently, insulin-like growth factors (or, as they were originally known, somatomedins) were thought to be produced in the liver in response to growth hormone, to circulate in the blood, and to mediate the effects of growth hormone (GH) on skeletal cartilage to promote bone elongation during childhood (Salmon and Daughaday 1957).
M. M. Rechler, S. P. Nissley
openaire +2 more sources
Until recently, insulin-like growth factors (or, as they were originally known, somatomedins) were thought to be produced in the liver in response to growth hormone, to circulate in the blood, and to mediate the effects of growth hormone (GH) on skeletal cartilage to promote bone elongation during childhood (Salmon and Daughaday 1957).
M. M. Rechler, S. P. Nissley
openaire +2 more sources
The Insulin-like Growth Factors and the Lung
American Journal of Respiratory Cell and Molecular Biology, 1990The insulin-like growth factors (IGF-I and IGF-II) are peptides of about 7,500 D with structural homology to proinsulin that are capable of stimulating cellular proliferation and inducing differentiation. They are each encoded by single, large, complex genes that direct the transcription of multiple mRNAs.
Alan D. Stiles, D'Ercole Aj
openaire +2 more sources
Endocrine reviews, 2009
In mammals, the insulin receptor (IR) gene has acquired an additional exon, exon 11. This exon may be skipped in a developmental and tissue-specific manner. The IR, therefore, occurs in two isoforms (exon 11 minus IR-A and exon 11 plus IR-B).
A. Belfiore +4 more
semanticscholar +1 more source
In mammals, the insulin receptor (IR) gene has acquired an additional exon, exon 11. This exon may be skipped in a developmental and tissue-specific manner. The IR, therefore, occurs in two isoforms (exon 11 minus IR-A and exon 11 plus IR-B).
A. Belfiore +4 more
semanticscholar +1 more source