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Insulin-like growth factors in obstetrics
Current Opinion in Obstetrics and Gynecology, 2000Data from a number of studies reported during the past two decades indicate that the insulin-like growth factor (IGF) system, including IGF-I and IGF-II, their receptors and six high-affinity binding proteins, is involved in the control of foetal and placental growth and development. Recent studies that addressed the role of the IGF system in pregnancy
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The Phylogeny of the Insulin-like Growth Factors
1998The insulin-like growth factors are major regulators of growth and development in mammals and their presence in lower vertebrates suggests that they played a similarly fundamental role throughout vertebrate evolution. While originally perceived simply as mediators of growth hormone, on-going research in mammals has revealed several hierarchical layers ...
Manfred Reinecke, Christopher Collet
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New England Journal of Medicine, 1997
The insulin-like growth factor (IGF) system includes two peptide ligands, IGF-I and IGF-II; their receptors, the IGF-I receptor and the mannose-6-phosphate receptor, and six IGF-binding proteins. This family of growth factors plays fundamental roles in normal physiology and in neoplastic and metabolic disease states.
Derek Le Roith, Haim Werner
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The insulin-like growth factor (IGF) system includes two peptide ligands, IGF-I and IGF-II; their receptors, the IGF-I receptor and the mannose-6-phosphate receptor, and six IGF-binding proteins. This family of growth factors plays fundamental roles in normal physiology and in neoplastic and metabolic disease states.
Derek Le Roith, Haim Werner
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Colocalization of insulin-like growth factor-binding protein with insulin-like growth factor I
American Journal of Physiology-Renal Physiology, 1991We report the localization of insulin-like growth factor I (IGF-I) and a 25-kDa form of insulin-like growth factor-binding protein (IGF-BP-1) in adult rat kidney. The antigens were localized using a rabbit anti-human IGF-I antibody, and a rabbit anti-human IGF-BP-1 antibody raised against human 25-kDa IGF-BP-1 purified from amniotic fluid ...
David R. Clemmons +2 more
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The Somatomedins: Insulin-Like Growth Factors
1986Publisher Summary This chapter presents an account of the recent advances in the understanding of the origins, functions, and clinical significance of insulin-like growth factors. The term “somatomedin” was coined over a decade ago to describe partly characterized plasma factors that (1) stimulated sulfate incorporation into chondroitin sulfate of ...
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American Journal of Physiology. Endocrinology and Metabolism, 2000
The insulin-like growth factor (IGF)-binding proteins (IGFBPs) are a family of six homologous proteins with high binding affinity for IGF-I and IGF-II.
R. Baxter
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The insulin-like growth factor (IGF)-binding proteins (IGFBPs) are a family of six homologous proteins with high binding affinity for IGF-I and IGF-II.
R. Baxter
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Biology of insulin‐like growth factors in development
Birth Defects Research Part C: Embryo Today: Reviews, 2003AbstractInsulin‐like growth factors (IGFs) provide essential signals for the control of embryonic and postnatal development in vertebrate species. In mammals, IGFs act through and are regulated by a system of receptors, binding proteins, and related proteases. In each of the many tissues dependent on this family of growth factors, this system generates
Dupont, Joëlle, Holzenberger, M.
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Biochemical and Biophysical Research Communications - BBRC, 2000
Bioglass 45S5 is an osteoproductive material, which resorbs by releasing its constitutive ions into solution. Treatment with the ionic products of Bioglass 45S5 dissolution in DMEM for 4 days increased human osteoblast proliferation to 155% of control ...
I. Xynos +4 more
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Bioglass 45S5 is an osteoproductive material, which resorbs by releasing its constitutive ions into solution. Treatment with the ionic products of Bioglass 45S5 dissolution in DMEM for 4 days increased human osteoblast proliferation to 155% of control ...
I. Xynos +4 more
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INSULIN-LIKE GROWTH FACTORS AND THEIR RECEPTORS IN GROWTH
Endocrinology and Metabolism Clinics of North America, 1996The IGFs are essential stimulators of fetal and postnatal growth. Their signals are mediated predominantly by the type I IGF receptor, but another as yet unidentified receptor seems to mediate some actions, especially some of those for IGF-II. During organogenesis, the actions of IGF-I seem to be local (autocrine/paracrine), because it, as well as ...
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Insulin and insulin-like growth factor signalling in neoplasia
Nature Reviews. Cancer, 2008M. Pollak
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