Results 241 to 250 of about 40,050,075 (282)

Insulin-like growth factor-1 and insulin-like growth factor receptor in thyroid tissues of patients with Graves' disease.

International Journal of Molecular Medicine, 1998
Growth factors are frequently involved in the regulation of mitosis and differentiation of several cell types and insulin-like growth factor-1 (IGF-1) is actively involved in the thyroid stimulating hormone-mediated proliferation of thyrocytes. In view of the pivotal role of IGF-1 in thyrocyte proliferation and of the still unsettled role of this ...
Maiorano E, Perlino E, Triggiani V, Nacchiero M, Giove E, Ciampolillo A   +5 more
openaire   +4 more sources

The complex biology of the receptor for the insulin-like growth factor-1

Drug News & Perspectives, 2003
The receptor for the insulin-like growth factor-1 (IGF-1R) controls a wide variety of cellular functions. IGF-1R is a tyrosine kinase receptor that is activated by the binding of a ligand to the extracellular domain. There are three ligands for IGF-1R: IGF-I, IGF-II and insulin at supraphysiological concentrations.
openaire   +2 more sources

Expression of insulin-like growth factor-1 and insulin-like growth factor-1 receptors in EL4 lymphoma cells overexpressing growth hormone

Cellular Immunology, 2005
Almost all of the previous studies with growth hormone (GH) have been done with exogenously supplied GH and, therefore, involve actions of the hormone through its receptor. However, the actions of endogenous or lymphocyte GH are still unclear. In a previous study, we showed that overexpression of GH (GHo) in a lymphoid cell line resulted in protection ...
Douglas A, Weigent, Robyn E, Arnold
openaire   +2 more sources

Seasonal expressions of growth hormone receptor, insulin-like growth factor 1 and insulin-like growth factor 1 receptor in the scented glands of the muskrats (Ondatra zibethicus)

General and Comparative Endocrinology, 2019
The growth hormone (GH)/insulin-like growth factor-1 (IGF-1) system plays an important role in regulating the cellular growth and organ development. The present study investigated the seasonal expressions of growth hormone receptor (GHR), IGF-1 and insulin-like growth factor 1 receptor (IGF-1R) in the scented glands of the muskrats.
Wenqian, Xie, Zeqi, Tang, Yuanyuan, Guo, Chunjiao, Zhang, Haolin, Zhang, Yingying, Han, Zhengrong, Yuan, Qiang, Weng   +7 more
openaire   +2 more sources

Growth and the Insulin-Like Growth Factor-1 Receptor (IGF1R)

2011
The insulin-like growth factor-1 receptor (IGF-1R) is a membrane-bound tyrosine kinase receptor capable of auto-phosphorylation following ligand binding. While IGF-1 is the major ligand for this receptor, both IGF-2 and insulin can bind to the IGF-1R.
Maria Belen Roldan Martin, Selma Feldman Witchel   +1 more
openaire   +1 more source

Association of Insulin-Like Growth Factor-1 Receptor Polymorphism in Dementia

Dementia and Geriatric Cognitive Disorders, 2006
There is an increasing interest in how oxidative stress can cause cells to go into apoptosis in both normal ageing and in neurodegenerative disorders. Previous research has implicated insulin-like growth factor-1 (IGF-1) as being involved in the pathogenesis in Alzheimer’s disease (AD) by protecting the neurons through reducing neuronal susceptibility ...
J, Garcia, A, Ahmadi, A, Wonnacott, W, Sutcliffe, K, Nagga, P, Soderkvist, J, Marcusson   +6 more
openaire   +2 more sources

Structure and function of the type 1 insulin-like growth factor receptor

Cellular and Molecular Life Sciences, 2000
The type 1 insulin-like growth factor receptor (IGF-1R), a transmembrane tyrosine kinase, is widely expressed across many cell types in foetal and postnatal tissues. Activation of the receptor following binding of the secreted growth factor ligands IGF-1 and IGF-2 elicits a repertoire of cellular responses including proliferation, and the protection of
T E, Adams, V C, Epa, T P, Garrett, C W, Ward   +3 more
openaire   +2 more sources

Targeted Therapy of the Insulin-Like Growth Factor-1 Receptor in Cancer

Combinatorial Chemistry & High Throughput Screening, 2008
Recently, significant progress has been made towards understanding the pathogenesis of cancer from the molecular standpoint. To this end, a growing number of approaches are being exploited for the identification and validation of new therapeutic targets suitable for potent and specific intervention.
Keren, Paz, Yaron R, Hadari
openaire   +2 more sources

Mini ReviewSignalling by the Type 1 Insulin-like Growth Factor Receptor: Interplay with the Epidermal Growth Factor Receptor

Growth Factors, 2004
The type 1 insulin-like growth factor receptor (IGF-1R) plays an essential role in mammalian growth and development, and has emerged as a candidate therapeutic target in the treatment of cancer. While the pleiotropic cellular responses elicited following tyrosine phosphorylation of the IGF-1R is usually seen to involve the direct recruitment/activation
Timothy E, Adams, Neil M, McKern, Colin W, Ward   +2 more
openaire   +2 more sources

Insulin Like Growth Factor 1 Receptor Signal Transduction to the Nucleus

1994
The mechanism by which IGF-1Rs regulate the growth and maintenance of cells in normal and disease states provides an important setting for studies addressing signal transduction events at the nuclear level. With the identification of c-Jun/AP-1 as a nuclear target of IGF-1 action we are provided with a model system for pursuing the molecular mechanisms
S A, Rosenzweig, B S, Oemar, N M, Law, U T, Shankavaram, B S, Miller   +4 more
openaire   +2 more sources