Results 251 to 260 of about 40,050,075 (282)

Insulin‐like growth factor‐1 receptor acts as a growth regulator in synovial sarcoma

The Journal of Pathology, 2008
AbstractSynovial sarcomas account for 5–10% of all soft tissue sarcomas and the majority of synovial sarcomas display characteristic t(X;18) translocations that result in enhanced transcription of the insulin‐like growth factor‐2 (IGF‐2) gene. IGF‐2 is an essential fetal mitogen involved in the pathogenesis of different tumours, leading to cellular ...
Friedrichs, N., Küchler, J., Endl, E., Koch, A., Czerwitzki, J., Wurst, P., Metzger, D., Schulte, Johannes, Holst, M. I., Heukamp, L. C., Larsson, O., Tanaka, S., Kawai, A., Wardelmann, E., Buettner, R., Pietsch, T., Hartmann, W.   +16 more
openaire   +2 more sources

Mutants of human insulin-like growth factor I with reduced affinity for the type 1 insulin-like growth factor receptor

Biochemistry, 1988
Four mutants of human insulin-like growth factor I (hIGF I) have been purified from the conditioned media of yeast transformed with an expression vector containing a synthetic gene for hIGF I altered by site-directed mutagenesis. hIGF I has the sequence Phe-23-Tyr-24-Phe-25 which is homologous to a region in the B-chain of insulin.
M A, Cascieri, G G, Chicchi, J, Applebaum, N S, Hayes, B G, Green, M L, Bayne   +5 more
openaire   +2 more sources

The insulin-like growth factor 1 receptor in cancer

European Journal of Cancer, 2007
The importance of insulin-like growth factor 1 receptor (IGF-1R) signalling in malignant behaviour of tumour cells is well established. Currently, development of drugs targeting the IGF-1R as anticancer treatment is emerging. Several IGF-1R targeting strategies are being investigated in phases I and II clinical trials.
Hartog, Hermien, Wesseling, Jelle, Boezen, H. Marike, van der Graaf, Winette T. A.   +3 more
openaire   +1 more source

Constitutive expression of insulin-like growth factor 1 and insulin-like growth factor 1 receptor abrogates all requirements for exogenous growth factors.

Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, 1992
BALB/c3T3 cells are exquisitely growth regulated and require both platelet-derived growth factor and insulin-like growth factor-1 (IGF-1) for optimal proliferation. BALB/c3T3 cells that constitutively express IGF-1 and elevated levels of IGF-1 receptor (IGF-1R) are capable of growth in serum-free medium without the addition of any exogenous growth ...
Z, Pietrzkowski, R, Lammers, G, Carpenter, A M, Soderquist, M, Limardo, P D, Phillips, A, Ullrich, R, Baserga   +7 more
openaire   +1 more source

Systemic therapy for hormone receptor‐positive/human epidermal growth factor receptor 2‐negative early stage and metastatic breast cancer

Ca-A Cancer Journal for Clinicians, 2023
Hope Rugo, Laura Huppert
exaly  

Insulin-Like Growth Factors 1 and 2, and Type 1 Insulin-Like Growth Factor Receptor in Cat Placenta

2023
Rocío Hernández, Gimena Gomez Castro, Fernanda Rodríguez, Luciano Casas, Enrique Portiansky, Florencia Rey, Claudio Barbeito, Mónica Diessler   +7 more
openaire   +1 more source

Insulin Receptor Isoforms and Insulin Growth Factor-like Receptors: Implications in Cell Signaling, Carcinogenesis, and Chemoresistance

International Journal of Molecular Sciences, 2023
Ahmad Aljada
exaly  

How IGF-II Binds to the Human Type 1 Insulin-like Growth Factor Receptor

Structure, 2020
Nicholas Stephen Kirk, Andrew Webb, Hariprasad Venugopal   +2 more
exaly  

Direct interaction of insulin-like growth factor-1 receptor with leukemia-associated RhoGEF

Journal of Cell Biology, 2001
Naoyuki Inagaki, Kozo Kaibuchi, A Iwamatsu   +2 more
exaly  

Cellular pattern of type-I insulin-like growth factor receptor gene expression during maturation of the rat brain: Comparison with insulin-like growth factors I and II

Neuroscience, 1992
Haim Werner, Charles Roberts, C Bondy
exaly