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Insulin-Like Growth Factor-Binding Protein [PDF]

Definitions, 1989
NEW MATERIAL: An insulin-like growth factor-binding protein comprising an amino acid sequence at least 85% homologous to the amino acid sequence beginning with position 1 and ending at position 289 represented by the formula or to any fragment thereof ...
C. Binkert, G. Heinrich, J. Schwander
semanticscholar   +2 more sources

In silico interaction of insulin-like growth factor binding protein 3 with insulin-like growth factor 1

Research in Pharmaceutical Sciences, 2018
Insulin-like growth factor binding protein-3 (IGFBP-3) is a vital protein exist in circulation which interacts with high affinity to insulin-like growth factor (IGFs) altering their activities.
Elham Jafari, Ali Gheysarzadeh, Karim Mahnam, Rezvan Shahmohammadi, Amir Ansari, Hadi Bakhtyari, Mohammad Reza Mofid   +6 more
doaj   +4 more sources

Correlation of Insulin Like Growth Factor-1 and Insulin-Like Growth Factor Binding Protein with LH, FSH and Testosterone in Iraqi Children with Growth Hormone Deficiency

Iraqi Journal of Chemical and Petroleum Engineering, 2023
Insulin like growth factor-1 has metabolic and growth-related roles all over the body and is strongly associated and regulated by growth hormone. It is produced by almost any type of tissue, especially the liver.
Athraa F. Hasan, Bushra F. Hassan, ABDILKAREEM Y. AL-SAMERAIE   +2 more
doaj   +1 more source

Transferrin binds insulin‐like growth factors and affects binding properties of insulin‐like growth factor binding protein‐3 [PDF]

FEBS Letters, 2001
In the circulation, most of the insulin‐like growth factors (IGFs) are bound to a ternary 150 kDa complex with IGF‐binding protein (IGFBP)‐3 and the acid labile subunit. In the current study, we identify transferrin (Tf) by mass spectrometry, and immunoprecipitation as a component of a major IGF‐binding fraction separated from human plasma.
Storch, S., Kubler, B., Honing, S., Ackmann, M., Zapf, J., Blum, W., Braulke, Thomas   +6 more
openaire   +3 more sources

Targeting Insulin-Like Growth Factor-I and Insulin-Like Growth Factor–Binding Protein-3 Signaling Pathways. A Novel Therapeutic Approach for Asthma

American Journal of Respiratory Cell and Molecular Biology, 2014
Hyun Lee, So Ri Kim, Youngman Oh
exaly   +2 more sources

The Aberrant Expression of MicroRNA-125a-5p/IGF2BP3 Axis in Advanced Gastric Cancer and Its Clinical Relevance

Technology in Cancer Research & Treatment, 2020
RNA-binding proteins have been associated with cancer development. The overexpression of a well-known RNA-binding protein, insulin-like growth factor 2 messenger RNA–binding protein 3, has been identified as an indicator of poor prognosis in patients ...
Jing Zhang MS, Fanghui Ding MD, Dan Jiao MS, Qiaozhi Li MS, Hong Ma MS   +4 more
doaj   +1 more source

Insulin-like growth factor (IGF)-I and IGF binding proteins axis in diabetes mellitus [PDF]

Annals of Pediatric Endocrinology & Metabolism, 2015
Increasing evidence suggests an important role of the insulin-like growth factor (IGF)-IGF binding protein (IGFBP) axis in the maintenance of normal glucose and lipid metabolism. Significant changes occur in the local IGF-I-IGFBPs environment in response
Min Sun Kim, Dae-Yeol Lee
doaj   +1 more source

Animal insulin-like growth factor binding proteins and their biological functions

Veterinární Medicína, 2002
Insulin-like growth factor (IGF-I, IGF-II) action is influenced by until today known eight forms of insulin-like growth factor binding proteins (IGFBPs).
Z. Kostecká, J. Blahovec
doaj   +1 more source

Cardiovascular disease risk markers in children under 10 years of age and their relationship with serum concentrations of IGF-1, IGFBP-1, IGFBP-2 and IGFBP-3

Revista de la Facultad de Medicina, 2020
Introduction: Any type of nutritional imbalance experienced during childhood will affect the health of an individual, both in their childhood and their adulthood.
Sorany Vera, Tatiana Figueroa, Luz Helena Aranzalez, Ismena Mockus   +3 more
doaj   +1 more source

Structural basis for the inhibition of insulin-like growth factors by insulin-like growth factor-binding proteins [PDF]

Proceedings of the National Academy of Sciences, 2006
Insulin-like growth factor-binding proteins (IGFBPs) control bioavailability, activity, and distribution of insulin-like growth factor (IGF)1 and -2 through high-affinity IGFBP/IGF complexes. IGF-binding sites are found on N- and C-terminal fragments of IGFBPs, the two conserved domains of IGFBPs.
Sitar, T., Popowicz, G., Siwanowicz, I., Huber, R., Holak, T.   +4 more
openaire   +3 more sources