Results 21 to 30 of about 462,862 (298)

Insulin Like Growth Factor Binding Protein 7 as a Novel Diagnostic Marker in Sera of Iraqi Patients with Acromegaly

مجلة بغداد للعلوم, 2023
The purpose of this study was to measure serum levels of insulin-like growth factor-binding protein (IGFBP7), Insulin-like Growth Factor 1 (IGF-1), Growth Hormone (GH), Interleukin 6 (IL-6) and insulin in acromegaly patients and healthy controls.
Layla Othman Farhan, Baydaa Ahmed Abed, Kashtl Ghasaq J., Isam Noori Salman   +3 more
doaj   +1 more source

The Role of Insulin-Like Growth Factors and Insulin-Like Growth Factor–Binding Proteins in the Nervous System [PDF]

Biochemistry Insights, 2019
The insulin-like growth factors (IGF-I and IGF-II) and their receptors are widely expressed in nervous tissue from early embryonic life. They also cross the blood brain barriers by active transport, and their regulation as endocrine factors therefore differs from other tissues.
Moira S Lewitt, Gary W Boyd
openaire   +2 more sources

Insulin-like growth factors and insulin-like growth factor binding proteins in mammary gland function [PDF]

Breast Cancer Research, 2002
Insulin-like growth factor (IGF)-mediated proliferation and survival are essential for normal development in the mammary gland during puberty and pregnancy. IGFs interact with IGF-binding proteins and regulate their function. The present review focuses on the role of IGFs and IGF-binding proteins in the mammary gland and describes how modulation of ...
Marshman, Emma, Streuli, Charles H.
openaire   +3 more sources

Urinary Tissue Inhibitor of Metalloproteinase-2 and Insulin-Like Growth Factor-Binding Protein 7 for Risk Stratification of Acute Kidney Injury in Patients With Sepsis

Critical Care Medicine, 2016
Objectives:To examine the performance of the urinary biomarker panel tissue inhibitor of metalloproteinase-2 and insulin-like growth factor-binding protein 7 in patients with sepsis at ICU admission.
P. Honore, H. Nguyen, M. Gong, L. Chawla, S. Bagshaw, A. Artigas, Jing Shi, O. Joannes-Boyau, J. Vincent, J. Kellum   +9 more
semanticscholar   +1 more source

Insulin-Like Growth Factor Binding Protein 2 (IGFBP-2) and the Risk of Developing Type 2 Diabetes

Diabetes, 2018
Recent studies suggest that insulin-like growth factor binding protein 2 (IGFBP-2) may protect against type 2 diabetes, but population-based human studies are scarce.
C. Wittenbecher, M. Ouni, O. Kuxhaus, M. Jähnert, P. Gottmann, A. Teichmann, K. Meidtner, J. Kriebel, H. Grallert, T. Pischon, H. Boeing, M. Schulze, A. Schürmann   +12 more
semanticscholar   +1 more source

Phosphorylation of Serine 256 by Protein Kinase B Disrupts Transactivation by FKHR and Mediates Effects of Insulin on Insulin-like Growth Factor-binding Protein-1 Promoter Activity through a Conserved Insulin Response Sequence*

Journal of Biological Chemistry, 1999
Insulin inhibits the expression of multiple genes in the liver containing an insulin response sequence (IRS) (CAAAA(C/T)AA), and we have reported that protein kinase B (PKB) mediates this effect of insulin.
Shaodong Guo, G. Rena, S. Cichy, Xiaowei He, P. Cohen, T. Unterman   +5 more
semanticscholar   +1 more source

Targeting insulin-like growth factor-binding protein-3 by microRNA-125b promotes tumor invasion and poor outcomes in non-small-cell lung cancer

Tumor Biology, 2017
Insulin-like growth factor-binding protein-3 acts as a tumor suppressor that inhibits the PI3K/AKT signaling pathway due to blocking insulin growth factor-1 binding to its receptor.
Hsiu-Hua Wang, Yao-Chen Wang, De-Wei Wu, Chin-Sheng Hung, Chih-Yi Chen, Huei Lee   +5 more
doaj   +1 more source

Adult growth hormone deficiency treatment with a combination of growth hormone and insulin-like growth factor-1 resulting in elevated sustainable insulin-like growth factor-1 and insulin-like growth factor binding protein 3 plasma levels: a case report

Journal of Medical Case Reports, 2010
Introduction Adult Growth hormone Deficiency is a well known phenomenon effecting both males and females. Adult Growth Hormone Deficiency is marked by a number of neuropsychiatric, cognitive performance, cardiac, metabolic, muscular, and bone symptoms ...
Madigan Margaret, Chen Thomas JH, Yeldandi Swetha, Damle Uma J, Bowirrat Abdalla, Braverman Eric R, Kerner Mallory, Huang Stanley X, Savarimuthu Stella, Blum Kenneth   +9 more
doaj   +1 more source

The Roles of Insulin-Like Growth Factor 2 mRNA-Binding Protein 2 in Cancer and Cancer Stem Cells

Stem Cells International, 2018
RNA-binding proteins (RBPs) mediate the localization, stability, and translation of the target transcripts and fine-tune the physiological functions of the proteins encoded. The insulin-like growth factor (IGF) 2 mRNA-binding protein (IGF2BP, IMP) family
Junguo Cao, Qingchun Mu, Haiyan Huang
semanticscholar   +1 more source

The insulin like growth factor and binding protein family: Novel therapeutic targets in obesity & diabetes

Molecular Metabolism, 2018
Background Recent changes in nutrition and lifestyle have provoked an unprecedented increase in the prevalence of obesity and metabolic disorders. Recognition of the adverse effects on health has prompted intense efforts to understand the molecular ...
N. Haywood, T. Slater, Connor J Matthews, S. Wheatcroft   +3 more
semanticscholar   +1 more source