Results 31 to 40 of about 462,862 (298)
Insulin-Like Growth Factor Binding Proteins: A Structural Perspective [PDF]
Frontiers in Endocrinology, 2012 Insulin-like growth factor binding proteins (IGFBP-1 to -6) bind insulin-like growth factors-I and -II (IGF-I and IGF-II) with high affinity. These binding proteins maintain IGFs in the circulation and direct them to target tissues, where they promote cell growth, proliferation, differentiation, and survival via the type 1 IGF receptor.
Forbes, B., McCarthy, P., Norton, R.
openaire +4 more sources
Technology in Cancer Research & Treatment, 2020 Osteosarcoma is the most common primary malignant bone tumor in the clinic. It is more common in children and adolescents. It has high malignancy, early metastasis rate, rapid disease progression, and high mortality.
Yuelong Tan MM +4 more
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Nuclear Actions of Insulin-like Growth Factor Binding Protein-3
Gene, 2015 In addition to its actions outside the cell, cellular uptake and nuclear import of insulin-like growth factor binding protein-3 (IGFBP-3) has been recognized for almost two decades, but knowledge of its nuclear actions has been slow to emerge.
R. Baxter
semanticscholar +1 more source
Insulin-Like Growth Factor-Binding Proteins of Teleost Fishes [PDF]
Frontiers in Endocrinology, 2018 The insulin-like growth factor (Igf) binding protein (Igfbp) family has a broad range of physiological functions and a fascinating evolutionary history. This review focuses on the Igfbps of teleost fishes, where genome duplication events have diversified gene repertoire, function, and physiological regulation-with six core Igfbps expanded into a family
de la Serrana, Daniel Garcia +1 more
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Insulin-like growth factor-I and its binding proteins in healthy mothers and their newborns [PDF]
Einstein (São Paulo), 2004 Objective: To determine serum levels of insulin-like growth factor-I, free insulin-like growth factor-I and its binding proteins in maternalserum and in cord blood of two groups of newborns with differentbirth weights.
Rosanna Velleca Lima +3 more
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The Insight into Insulin-Like Growth Factors and Insulin-Like Growth-Factor-Binding Proteins and Metabolic Profile in Pediatric Obesity [PDF]
Nutrients, 2021 Insulin-like growth factors (IGFs) and insulin-like growth-factor-binding proteins (IGFBPs) regulate cell proliferation and differentiation and may be of importance in obesity development. The aim of the study was to analyze the expression of chosen IGF-axis genes and the concentration of their protein products in 28 obese children (OB) and 34 healthy ...
Wojciech Czogała +9 more
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IGF-Binding Proteins: Why Do They Exist and Why Are There So Many?
Frontiers in Endocrinology, 2018 Insulin-like growth factors (IGFs) are key growth-promoting peptides that act as both endocrine hormones and autocrine/paracrine growth factors. In the bloodstream and in local tissues, most IGF molecules are bound by one of the members of the IGF ...
John B. Allard, Cunming Duan
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IGF-I and IGFBP-3 serum levels in patients hospitalized for complications of liver cirrhosis
Annals of Hepatology, 2013 Background. IGF-I and IGFBP-3 are part of IGF system and, due to their predominantly hepatic synthesis, they seem to correlate with hepatic dysfunction intensity. Aims.
Marcelo Fernando Ronsoni +8 more
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Journal of Tissue Engineering, 2019 Angiogenesis in adipose tissue is promoted by insulin-like growth factor 1 signaling. We analyzed whether this regulatory mechanism also improves the angiogenic activity of adipose tissue–derived microvascular fragments.
Matthias W Laschke +5 more
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Journal of Biological Chemistry, 2001 A novel metalloproteinase with similarity to pregnancy-associated plasma protein-A (PAPP-A), which we denoted PAPP-A2, has been identified. Through expression in mammalian cells we showed that recombinant PAPP-A2 polypeptide of 1558 residues resulted ...
M. Overgaard +5 more
semanticscholar +1 more source