Results 21 to 30 of about 416,432 (306)

In silico interaction of insulin-like growth factor binding protein 3 with insulin-like growth factor 1

Research in Pharmaceutical Sciences, 2018
Insulin-like growth factor binding protein-3 (IGFBP-3) is a vital protein exist in circulation which interacts with high affinity to insulin-like growth factor (IGFs) altering their activities.
Elham Jafari, Ali Gheysarzadeh, Karim Mahnam, Rezvan Shahmohammadi, Amir Ansari, Hadi Bakhtyari, Mohammad Reza Mofid   +6 more
doaj   +1 more source

Regulation of multiple insulin-like growth factor binding protein genes by 1α,25-dihydroxyvitamin D(3) [PDF]

, 2005
Recently, insulin-like growth factor binding proteins (IGFBPs) have been found to be primary mediators of the anti-proliferative actions of the nuclear hormone 1α,25-dihydroxyvitamin D(3) [1α,25(OH)(2)D(3)], but dependent on cellular context IGFBPs can ...
Carlberg, Carsten, Malinen, Marjo, Matilainen, Merja, Saavalainen, Katri   +3 more
core   +3 more sources

Serum Insulin-like Growth Factors and Insulin-like Growth Factor-binding Proteins: Clinical Implications [PDF]

Clinical Chemistry, 1999
AbstractThe last decade has been characterized by a major investigative thrust into the physiology of two unique but ubiquitous peptides, insulin-like growth factor (IGF)-I and IGF-II. The regulatory systems that control the tissue bioactivity of the IGFs have been delineated, and subcellular signaling mechanisms have been clarified.
openaire   +2 more sources

Insulin-like growth factors and insulin-like growth factor binding proteins in mammary gland function [PDF]

Breast Cancer Research, 2002
Insulin-like growth factor (IGF)-mediated proliferation and survival are essential for normal development in the mammary gland during puberty and pregnancy. IGFs interact with IGF-binding proteins and regulate their function. The present review focuses on the role of IGFs and IGF-binding proteins in the mammary gland and describes how modulation of ...
Marshman, Emma, Streuli, Charles H.
openaire   +3 more sources

Targeting insulin-like growth factor-binding protein-3 by microRNA-125b promotes tumor invasion and poor outcomes in non-small-cell lung cancer

Tumor Biology, 2017
Insulin-like growth factor-binding protein-3 acts as a tumor suppressor that inhibits the PI3K/AKT signaling pathway due to blocking insulin growth factor-1 binding to its receptor.
Hsiu-Hua Wang, Yao-Chen Wang, De-Wei Wu, Chin-Sheng Hung, Chih-Yi Chen, Huei Lee   +5 more
doaj   +1 more source

Adult growth hormone deficiency treatment with a combination of growth hormone and insulin-like growth factor-1 resulting in elevated sustainable insulin-like growth factor-1 and insulin-like growth factor binding protein 3 plasma levels: a case report

Journal of Medical Case Reports, 2010
Introduction Adult Growth hormone Deficiency is a well known phenomenon effecting both males and females. Adult Growth Hormone Deficiency is marked by a number of neuropsychiatric, cognitive performance, cardiac, metabolic, muscular, and bone symptoms ...
Madigan Margaret, Chen Thomas JH, Yeldandi Swetha, Damle Uma J, Bowirrat Abdalla, Braverman Eric R, Kerner Mallory, Huang Stanley X, Savarimuthu Stella, Blum Kenneth   +9 more
doaj   +1 more source

Insulin-Like Growth Factor-I and Epidermal Growth Factor Regulate Insulin-Like Growth Factor Binding Protein-3 (IGFBP-3) in the Human Keratinocyte Cell Line HaCaT [PDF]

, 1995
The human keratinocyte cell line HaCaT has a basal phenotype and secretes an insulin-like growth factor (IGF) binding protein, IGFBP-3, which modulates its IGF-I response.
Werther, George A., Wraight, Christopher J.   +1 more
core   +1 more source

MiR-384 Inhibits Malignant Biological Behavior Such as Proliferation and Invasion of Osteosarcoma by Regulating IGFBP3

Technology in Cancer Research & Treatment, 2020
Osteosarcoma is the most common primary malignant bone tumor in the clinic. It is more common in children and adolescents. It has high malignancy, early metastasis rate, rapid disease progression, and high mortality.
Yuelong Tan MM, Linlin Chen MM, Siwei Li MM, He Hao MM, Delong Zhang MM   +4 more
doaj   +1 more source

Biomarkers of systemic inflammation and growth in early infancy are associated with stunting in young Tanzanian children [PDF]

, 2018
Stunting can afflict up to one-third of children in resource-constrained countries. We hypothesized that low-grade systemic inflammation (defined as elevations in serum C-reactive protein or alpha-1-acid glycoprotein) in infancy suppresses the growth ...
Aboud, Said, Duggan, Christopher P., Fawzi, Wafaie W., Kisenge, Rodrick, Liu, Enju, Locks, Lindsey, Manji, Karim P., McDonald, Christine M., Sudfeld, Christopher, Syed, Sana   +9 more
core   +1 more source

Insulin-Like Growth Factor Binding Proteins: A Structural Perspective [PDF]

Frontiers in Endocrinology, 2012
Insulin-like growth factor binding proteins (IGFBP-1 to -6) bind insulin-like growth factors-I and -II (IGF-I and IGF-II) with high affinity. These binding proteins maintain IGFs in the circulation and direct them to target tissues, where they promote cell growth, proliferation, differentiation, and survival via the type 1 IGF receptor.
Forbes, B., McCarthy, P., Norton, R.
openaire   +4 more sources