Results 61 to 70 of about 416,432 (306)

MTOR cross-talk in cancer and potential for combination therapy [PDF]

, 2018
The mammalian Target of Rapamycin (mTOR) pathway plays an essential role in sensing and integrating a variety of exogenous cues to regulate cellular growth and metabolism, in both physiological and pathological conditions.
Bazzichetto, C., Bria, E., Ciuffreda, L., Cognetti, F., Conciatori, F., Falcone, I., Milella, M, Pilotto, S.   +7 more
core   +3 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Insulin-like Growth Factor Binding Protein 7 Mediates Glioma Cell Growth and Migration

Neoplasia: An International Journal for Oncology Research, 2008
Insulin-like growth factor binding protein 7 (IGFBP-7) is the only member of the IGFBP superfamily that binds strongly to insulin, suggesting that IGFBP-7 may have different functions from other IGFBPs.
Wei Jiang, Cunli Xiang, Simona Cazacu, Chaya Brodie, Tom Mikkelsen   +4 more
doaj   +1 more source

Differential interactions between IGFBP-3 and transforming growth factor-beta (TGF-β) in normal vs cancerous breast epithelial cells [PDF]

In addition to modulating insulin-like growth factors action, it is now clear that insulin-like growth factor-binding protein-3 also has intrinsic effects on cell growth and survival.
AC Williams, AD Hollowood, AD Hollowood, AM Taylor, CA Fowler, CM Perks, CM Perks, CM Perks, CM Perks, CW Daniel, HD Soule, JI Jones, JL Martin, KL Schmeichel, KW Colston, LI Gold, M Reiss, MA Chrenek, ME Yateman, P Cohen, R Rajah, S Fanayan, S Kansra, SC Davies, SM Leal, Y Oh, Y Oh, Y Oh, Z Pietrzkowski, ZP Gill   +29 more
core   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Do insulin-like growth factor associated proteins qualify as a tumor marker? results of a prospective study in 163 cancer patients*

European Journal of Medical Research, 2011
Objective Insulin-like growth factor (IGF)-1, -2 and Insulin like growth factor binding proteins (IGFBP) are involved in the proliferation and differentiation of cells.
Matuschek G, Rudoy M, Peiper M, Gerber PA, Hoff NP, Buhren BA, Flehmig B, Budach W, Knoefel WT, Bojar H, Prisack HB, Steinbach G, Shukla V, Schwarz A, Kammers K, Erhardt A, Scherer A, Bölke E, Schauer M   +18 more
doaj   +1 more source

Recent Insights into Insulin-Like Growth Factor Binding Protein 2 Transcriptional Regulation [PDF]

Endocrinology and Metabolism, 2017
Insulin-like growth factor binding proteins (IGFBPs) are major regulators of insulin-like growth factor bioavailability and activity in metabolic signaling. Seven IGFBP family isoforms have been identified.
Minsang Shin, Hye Suk Kang, Jae-Hyung Park, Jae-Hoon Bae, Dae-Kyu Song, Seung-Soon Im   +5 more
doaj   +1 more source

Tonsillectomy and Weight Gain in Children, Is There a Correlation? [PDF]

, 2013
The relationship between tonsillectomy and postoperative weight gain in children has been studied across the globe. Indications for tonsillectomy include chronic recurrent tonsillitis and obstructive sleep apnea.
Doucette, Jacqueline M
core   +1 more source

Insulin-Like Growth Factor-I and Insulin-Like Growth Factor Binding Protein-3 in Alzheimer's Disease [PDF]

The Journal of Clinical Endocrinology & Metabolism, 2012
Few large studies have been conducted to assess the relationship between circulating IGF and late-life cognition.The aim of the study was to assess the relationship between IGF-I and IGF binding protein-3 (IGFBP-3) serum levels and cognitive impairment, including Alzheimer's disease (AD).In this multicentric cross-sectional study, 694 elderly subjects (
Duron, Emmanuelle, Funalot, Benoît, Brunel, Nadège, Coste, Joël, Quinquis, Laurent, Viollet, Cécile, Belmin, Joël, Jouanny, Pierre, Pasquier, Florence, Tréluyer, Jean-Marc, Epelbaum, Jacques, Le Bouc, Yves, Hanon, Olivier   +12 more
openaire   +3 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source