Results 111 to 120 of about 239,986 (298)

Knochenalterassozierte IGF-I und IGFBP-3 Befunde [PDF]

, 2008
Ziel der Arbeit war es aus einem Kollektiv kleinwüchsiger, entwicklungsverzögerter, präpubertärer und sonst gesunder, nicht hGH defizienter Kinder, IGF-I und IGFBP-3 Werte zu sammeln, diese auf das chronologische Alter zu beziehen und mit bereits ...
Grosse, Christina Maria
core  

Retinol-binding protein 4 in polycystic ovary syndrome--association with steroid hormones and response to pioglitazone treatment [PDF]

, 2009
CONTEXT: Polycystic ovary syndrome (PCOS) is frequently associated with insulin resistance. OBJECTIVE: The aim of the study was to investigate a putative role of the adipokines retinol-binding protein 4 (RBP4), adiponectin, and visfatin in a cohort of ...
Aigner, Elmar, Patsch, Wolfgang, Bachofner, Nora, Klein, Kerstin, Datz, Christian, Hohla, Florian, De Geyter, Christian   +6 more
core   +1 more source

Chromosomal Instability Drives Glioblastoma Heterogeneity and Therapeutic Opportunities

Advanced Science, EarlyView.
ABSTRACT Glioblastoma, the most aggressive and lethal form of brain cancer, is defined by profound genomic instability, with Chromosomal Instability (CIN) playing a central role in driving tumor progression, therapy resistance, and poor prognosis. CIN is characterized by numerical and structural alterations, is driven by mechanisms such as mitotic ...
Amarnath Pal, Milan Patra, Rianita Mondal, Shubhasis Haldar   +3 more
wiley   +1 more source

A novel liver specific isoform of the rat LAR transcript is expressed as a truncated isoform encoded from a 5 ' UTR located within intron 11 [PDF]

, 2009
Background: The leukocyte common antigen related receptor (LAR) protein has been shown to modulate the signal transduction of a number of different growth factors, including insulin and insulin-like growth factor 1.
Salter, AM, Welham, SJ, Simon JM Welham, Clark, AJ, Adrian JL Clark, Andrew M Salter   +5 more
core   +1 more source

QBP1 Peptide as a Potential Anti‐Amyloidogenic Therapy for Type 2 Diabetes: An In Vitro Study

Advanced Science, EarlyView.
The anti‐amyloidogenic peptide QBP1 effectively halts human islet amyloid polypeptide (hIAPP) aggregation, preventing the formation of toxic β‐structured intermediates. Through a combination of biophysical assays, molecular dynamics, and cell‐based studies, QBP1 is shown to preserve β‐cell viability and metabolic homeostasis, positioning it as a ...
María M. Tejero‐Ojeda, Ada Bernaus Vives, Michał Wojciechowski, Dinh Quoc Huy Pham, Mateusz Chwastyk, Mario Vallejo, Anna Novials, Douglas V. Laurents, Mariano Carrión‐Vázquez   +8 more
wiley   +1 more source

Genomic analysis of the function of the transcription factor gata3 during development of the Mammalian inner ear [PDF]

, 2009
We have studied the function of the zinc finger transcription factor gata3 in auditory system development by analysing temporal profiles of gene expression during differentiation of conditionally immortal cell lines derived to model specific auditory ...
Kneebone, A., Hikke Van Doorninck, Grace Lawoko-Kerali, Lawoko-Kerali, G. (Grace), Rivolta, Marcelo, Van Doorninck, H., Milo, M. (Marta), Milo Marta, Van Doorninck Hikke, Johnson, Claire, Doorninck, J.H. (Hikke) van, Johnson, C. (Claire), Milo, M., Lawoko-Kerali, Grace, Niranjan Mahesan, Holley Matthew, Cacciabue-Rivolta, Daniela, Van Doorninck, Hikke, Adam Kneebone, Mahesan Niranjan, Lawoko-Kerali, G., Holley, M., Milo, Marta, Lawoko-Kerali Grace, Johnson Claire, Marta Milo, Kneebone Adam, Kneebone, Adam, Niranjan, M., Holley, Matthew, Holley, M. (Matthew), Claire Johnson, Cacciabue-Rivolta, D. (Daniela), Daniela Cacciabue-Rivolta, Niranjan, M. (Mahesan), Rivolta Marcelo, Rivolta, M., Niranjan, Mahesan, Marcelo Rivolta, Cacciabue-Rivolta Daniela, Cacciabue-Rivolta, D., Rivolta, M. (Marcelo), Matthew Holley, Kneebone, A. (Adam), Johnson, C.   +44 more
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Malectin Alleviates Endoplasmic Reticulum Stress in Gestational Diabetes Mellitus via Glycoprotein Quality Control Mechanisms

Advanced Science, EarlyView.
Malectin alleviates high glucose‐induced ER stress and damage in placental trophoblasts, a function dependent on its six critical carbohydrate‐binding residues. In a GDM mouse model, administration of TAT‐Malectin ameliorated hyperglycemia and placental ER stress and prevented fetal macrosomia.
Jiahui Zhu, Yumeng Zhang, Ye Wang, Xiaoyu Zhu, Ailin Yuan, Weijing Yin, Huangmin Yu, Xuemin Pang, Yufeng He, Yuchen Wang, Tong Wang, Yong Li, Yunlong Si   +12 more
wiley   +1 more source

Níveis sérico de IGF-I e IGFBP-3 em pacientes admitidos por complicações da cirrose hepática [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde. Mestrado Profissional Associado à Residência Médica em Cuidados Intensivos e PaliativosIntrodução: IGF-I e IGFBP-3 fazem parte do sistema IGF e, por terem ...
Ronsoni, Marcelo Fernando
core  

LC3B Mediated SETDB1‐Accounted Alcoholic Steatohepatitis via Lipidation‐Dependent LAP and Lipidation‐Independent Nuclear Stabilization

Advanced Science, EarlyView.
SETDB1 is progressively downregulated in ALD, correlating with disease severity. SETDB1 deficiency impairs LAP by disrupting Rubicon membrane localization, leading to defective lipid droplet clearance. Concurrently, loss of SETDB1 reduces nuclear LC3B, causing R‐loop accumulation and cGAS‐STING‐driven inflammation. Lipidated LC3B mediates LAP‐dependent
Yi Zhang, Tan Wei, Jiahang Wu, Chuixu Lin, Dongbo Zhu, Yanhui Li, Shuting Shi, Shishun Huang, Leiming Jiang, Hongzhi Wang, Meiqi Song, Pengfei Gao, Xu Wu, Mingjian Fan, Chaofeng Wei, Qian Wang, Lihui Qu, Zhigang Wang   +17 more
wiley   +1 more source

Association of IGF-1 and IGFBP-3 with metabolic abnormalities among children and adolescents

Frontiers in Endocrinology
Background and ObjectiveInsulin-like growth factor-1 (IGF-1) and insulin-like growth factor binding protein-3 (IGFBP-3) play roles in growth and development, but their association with metabolic abnormalities in children and adolescents remains unclear ...
Zhenghao Zhao, Yuanyuan Ma, Xinyi Zhang, Xiaoxiao Liu, Yang Li, Zhongze Fang, Zhongze Fang, Zhongze Fang, Rongxiu Zheng, Jing Li, Jing Li, Jing Li   +11 more
doaj   +1 more source